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Status unknownNCT00631501Updated Mar 7, 2008

Doxycycline for Lateral Epicondylalgia - RCT

An interventional study of Placebo and Doxycycline in Lateral Epicondylalgia (Tennis Elbow), sponsored by Kaunas University of Medicine. Status unknown at 1 site in Lithuania. Open to participants aged 18 Years to 65 Years. Per ClinicalTrials.gov, last updated 2008-03-07.

Sponsored by Kaunas University of Medicine · Not applicable, Interventional, and Treatment

The sponsor has not verified this record recently (last verified Feb 2008), so the status shown — last known as Recruiting — may be out of date.
Phase
Not applicable
Study type
Interventional
Enrollment
34
Allocation
Randomized
Ages
18 Years to 65 Years
Sex
All
01

Study summary

Matrix metalloproteinases are involved in the pathogenesis of tendinopathy. Doxycycline, a widely available pharmaceutical agent mostly used for its antibiotic properties, also functions as an inhibitor of MMPs.

This study aims to investigate the effect of doxycycline treatment on lateral epicondylalgia (tennis elbow). During three weeks, patients receive doxycycline tablets 100 mg twice daily, or placebo. Main outcome variable is pain (VAS) at three weeks.

Serum and/or plasma levels of matrix metalloproteinases and tissue inhibitors of metalloproteinases are measured.

02

Conditions studied

  • Lateral Epicondylalgia (Tennis Elbow)

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Keywords

  • tendinopathy
  • tennis elbow
  • lateral epicondylitis
  • lateral epicondylalgia
  • MMP-inhibitor
03

In context

Tennis Elbow

284 studies on the registry are indexed under Tennis Elbow; 60 are open to participants now.

This study's planned enrollment of 34 is below the median of 50 across 253 interventional studies indexed under Tennis Elbow.

Browse Tennis Elbow studies →

Lead sponsor

Kaunas University of Medicine is the lead sponsor of 7 studies on the registry; none are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 65 Years
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • Age 18-65
  • Pain at the lateral side of the elbow ≥8 weeks
  • Local tenderness on palpation of the lateral epicondyle
  • Pain on resisted extension of the wrist

Exclusion criteria

Exclusion Criteria:

  • Rheumatic disorder
  • History of fibromyalgia or generalised pain
  • Elbow surgery (on the painful side)
  • Active infection
  • Glucocorticoid treatment during the duration of symtoms of epicondylalgia
  • NSAID use within 1 w before presentation and during the study
  • Pregnancy
  • Taking drug that might interact with doxycycline
05

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Triple (Participant, Care provider, Investigator)
Enrollment
34 participants (estimated)

Study arms

  • Placebo comparator
    2

    Drug: Placebo

  • Experimental
    Doxycycline

    100 mg twice daily

    Drug: Doxycycline

Interventions

  • DrugPlacebo
  • DrugDoxycycline
06

What researchers measure

Primary outcomes

  1. Pain (VAS)

07

Study locations

1 of 1 sites recruiting
  • Dept of Orthopaedics, Kaunas Medical University
    Kaunas, Lithuania
    Recruiting
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Mar 7, 2008, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT00631501
Lead sponsor
Kaunas University of Medicine
Collaborators
University Hospital, Linkoeping
First posted
Mar 7, 2008
Last update
Mar 7, 2008

Study contacts

Alfredas Smailys, MD, PhD
Contact
smailys@takas.lt
+370 37 327201
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is status unknown, as verified in Feb 2008. You cannot join it, but the record below documents what was studied.

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