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No longer availableNCT00590915EMTPUpdated Jan 23, 2026

Erwinase Master Treatment Protocol

An expanded access record providing Erwinia L-asparaginase in Leukemia, Acute Lymphoblastic and Acute Lymphoid Leukemia, sponsored by Phoenix Children's Hospital. No longer available. Per ClinicalTrials.gov, last updated 2026-01-23.

Sponsored by Phoenix Children's Hospital · Expanded access

Study type
Expanded access
Sex
All
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Study summary

The purpose of this study is to make Erwinase available to patients with acute lymphoblastic leukemia (ALL) who have had previous allergic reactions to certain formulations of L-asparaginase.

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Conditions studied

  • Leukemia, Acute Lymphoblastic
  • Acute Lymphoid Leukemia

Keywords

  • ALL
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In context

Precursor Cell Lymphoblastic Leukemia-Lymphoma

2,061 studies on the registry are indexed under Precursor Cell Lymphoblastic Leukemia-Lymphoma; 490 are open to participants now.

Browse Precursor Cell Lymphoblastic Leukemia-Lymphoma studies →

Lead sponsor

Phoenix Children's Hospital is the lead sponsor of 40 studies on the registry; 6 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
Child (0–17), Adult (18–64), Older adult (65+)
Sexes eligible
All

Inclusion criteria

  • Patient must give written informed consent to receive Erwinase.
  • Patient must be treated for acute lymphoblastic leukemia.
  • Patient must have either systemic hypersensitivity reactions to native (Elspar) or pegylated E.coli asparaginase (Oncaspar). This includes patients with generalized rash with or without anaphylactic symptoms, or patients with previously documented local or systemic reactions to E.coli derived L-asparaginase.

Exclusion criteria

Exclusion Criteria:

  • Previous allergic reaction to Erwinia L-asparaginase (Erwinase)
  • Previous acute pancreatitis
  • Pregnant or lactating woman
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Access details

Study type
Expanded access

Available treatment

  • DrugErwinia L-asparaginase

    Substitute Erwinia L-asparaginase 25,000 international units per meters squared, IM every other day (including weekends and holidays) x 6 doses for each dose of PEG-asparaginase that is replaced. NOTE: Erwinia L-asparaginase dosing to replace native E.coli L-asparaginase varies; consult protocol for specifics.

    Also known as: Erwinase

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Where to request access

No study locations are listed for this record.

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References and documents

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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jan 23, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT00590915
Lead sponsor
Phoenix Children's Hospital
Collaborators
Fisher Bioservices, Jazz Pharmaceuticals
Responsible party
Sponsor
First posted
Jan 11, 2008
Last update
Jan 23, 2026
View the source record on ClinicalTrials.gov ↗

Requesting access

Expanded access is arranged between your doctor and the company. Ask your care team to contact the provider listed on this record.

No contact was published for this record. The registry link below has the sponsor’s details.

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Discussion

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