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CompletedNCT00581841Updated May 17, 2013

Repeatability of X-Ray, MRI, and Gait Analysis

An observational study in Healthy, sponsored by Mayo Clinic. Completed at 1 site in United States. Open to participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2013-05-17.

Sponsored by Mayo Clinic · Observational

Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
60
Ages
18 Years and older
Sex
All
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Study summary

The purpose of this preliminary substudy to the parent study "Aerobic Exercise Intervention for Knee Osteoarthritis" is to determine the repeatability and reproducibility of various measurement techniques.

Read the detailed description

The purpose of this preliminary substudy to the parent study "Aerobic Exercise Intervention for Knee Osteoarthritis" is to determine the repeatability and reproducibility of various measurement techniques. The study will enroll healthy volunteers. All participants will receive x-rays and MRI examinations of the knees. Walking characteristics will be evaluated in a Motion Analysis Lab; this will involve taping reflective markers to participants' skin and having them walk on a level surface and up and down stairs. All participants will be evaluated two times, with a 1-week period between evaluations.

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Conditions studied

  • Healthy

Keywords

  • Healthy adult normals
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In context

Lead sponsor

Mayo Clinic is the lead sponsor of 3,218 studies on the registry; 670 are open to participants now.

Of its 445 completed or terminated interventional studies of FDA-regulated products, 313 (70%) have results posted.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
Yes
Sampling method
Non-probability sample

Study population

Community sample

Inclusion criteria

  • Healthy adults

Exclusion criteria

Exclusion Criteria:

  • Previous knee injury, knee pain, or knee osteoarthritis
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Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
60 participants (estimated)

Groups and cohorts

  • 1

    Healthy adult participants with no history of knee injury or osteoarthritis.

    Other: Gait analysis, knee x-ray, and knee MRI

Interventions

  • OtherGait analysis, knee x-ray, and knee MRI

    Gait analysis, knee x-rays, and knee MRIs will be done twice for each participant, 1 week apart.

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What researchers measure

Primary outcomes

  1. Day-to-day and inter/intra examiner repeatability of the techniques to be used in NIH grant R01 AR48768

    Time frame: Measured two times, with a 1-week period between evaluations

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Study locations

1 site
  • Mayo Clinic
    Rochester, Minnesota 55905, United States
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References and documents

Publications

  • Schmidt JE, Amrami KK, Manduca A, Kaufman KR. Semi-automated digital image analysis of joint space width in knee radiographs. Skeletal Radiol. 2005 Oct;34(10):639-43. doi: 10.1007/s00256-005-0908-9. Epub 2005 May 25. PubMed 15915340 ↗
  • Grochowski SJ, Amrami KK, Kaufman K. Semi-automated digital image analysis of patellofemoral joint space width from lateral knee radiographs. Skeletal Radiol. 2005 Oct;34(10):644-8. doi: 10.1007/s00256-005-0944-5. Epub 2005 Jul 15. PubMed 16021447 ↗
  • Koff MF, Amrami KK, Kaufman KR. Clinical evaluation of T2 values of patellar cartilage in patients with osteoarthritis. Osteoarthritis Cartilage. 2007 Feb;15(2):198-204. doi: 10.1016/j.joca.2006.07.007. Epub 2006 Sep 1. PubMed 16949313 ↗
  • Agnesi F, Amrami KK, Frigo CA, Kaufman KR. Semiautomated digital analysis of knee joint space width using MR images. Skeletal Radiol. 2007 May;36(5):437-44. doi: 10.1007/s00256-006-0245-7. Epub 2007 Jan 23. PubMed 17242952 ↗
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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on May 17, 2013, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT00581841
Lead sponsor
Mayo Clinic
Collaborators
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
First posted
Dec 28, 2007
Start date
Nov 2002
Primary completion
Jun 2003
Completion
Jun 2003
Last update
May 17, 2013

Study contacts

Kenton R. Kaufman, PhD
principal investigator · Mayo Clinic

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in May 2013. You cannot join it, but the record below documents what was studied.

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