An observational study in Hypoactive Sexual Desire Disorder and Erectile Dysfunction, sponsored by Hadassah Medical Organization. Suspended. Open to participants aged 21 Years to 65 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2010-06-10.
Sponsored by Hadassah Medical Organization · Observational
The current study combines a molecular genetic perspective, self report and brain imaging to the study of human sexuality in control subjects and individuals from a sexual disorder clinic. The investigators hypothesize that the variability in components of the brain dopaminergic system expressed in the mesolimbic reward system can explain variability in human sexuality, especially in desire and pleasure associated with sex.
We intend to combine molecular genetics of the dopamine receptors (D2, D3 D4 and D5) and brain imaging using 11 C Raclopride in Positron Emission Tomography (PET). 11 C Raclopride is a ligand which binds to the dopamine receptor D2 and can measure dopamine release during pleasure or anticipatory reward associated with sex. The current proposal will measure changes in DRD2 receptor occupancy using 11 C Raclopride following explicit visual sexual desire cues in healthy control subjects and individuals who suffer from sexual dysfunction. This is in order to determine how individual genotypes modulate dopamine release in vivo in the human brain.
682 studies on the registry are indexed under Erectile Dysfunction; 116 are open to participants now.
This study's planned enrollment of 40 is below the median of 130 across 115 observational studies indexed under Erectile Dysfunction.
Browse Erectile Dysfunction studies →Hadassah Medical Organization is the lead sponsor of 659 studies on the registry; 54 are open to participants now.
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A group of healthy volunteers from the general public. A group of patients who suffer from sexual disorder from a primary care clinic.
Exclusion Criteria:
Healthy control subjects (n=20) age 21-65 who do not suffer from a psychiatric diagnosis or neurological damage, are under age, or are pregnant women
20 patients who suffer from sexual disorder (reduced sexual desire or sexual function) from a sexual disorder clinic, age 21-65, without any other psychiatric disorder, neurological damage, are not under age or pregnant women.
Brain Imaging data of DRD2 receptor occupancy during watching a sex videotape and neutral videotape
Time frame: 2 Brain imaging sessions a week apart
Questionnaire ratings of human sexuality, pleasure, and anticipatory reward
Time frame: Taken during brain scans
No study locations are listed for this record.
This study is suspended, as verified in Jun 2010. You cannot join it, but the record below documents what was studied.
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Hadassah Medical Organization