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CompletedNCT00564005Updated Feb 11, 2015

Mechanism and Efficacy of Rehabilitation Approaches

An interventional study of Constraint-induced therapy (CIT) and Bilateral arm training (BAT) in Cerebrovascular Accidents, sponsored by Chang Gung Memorial Hospital. Completed at 1 site in Taiwan. Open to participants aged 40 Years to 75 Years. Per ClinicalTrials.gov, last updated 2015-02-11.

Sponsored by Chang Gung Memorial Hospital · Not applicable, Interventional, and Treatment

Phase
Not applicable
Study type
Interventional
Enrollment
90
Allocation
Randomized
Ages
40 Years to 75 Years
Sex
All
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Study summary

Identify the possible mechanisms and the relative effectiveness of existing rehabilitation approaches that target upper extremity deficits of stroke patients on the ground that these approaches are based on neuroplasticity principles and sound motor control theories.

Read the detailed description

Comparisons of constraint-induced therapy (CIT) vs. bilateral arm training (BIT)vs. combined therapy were made. Stroke patients will receive one of these three approaches and be evaluated pre- and post-treatment. the treatment will last 3 weeks and 5 days per week. The evaluation will include clinical measures of motor function, ADL, and quality of life, kinematic performance, and activation patterns of cortex.

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Conditions studied

  • Cerebrovascular Accidents

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Keywords

  • stroke rehabilitation
  • cortical reorganization
  • kinematic analysis
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In context

Stroke

7,283 studies on the registry are indexed under Stroke; 2,013 are open to participants now.

This study's enrollment of 90 is above the median of 50 across 5,366 interventional studies indexed under Stroke.

Browse Stroke studies →

Lead sponsor

Chang Gung Memorial Hospital is the lead sponsor of 1,064 studies on the registry; 235 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
40 Years to 75 Years
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • a first-ever clinical cerebrovascular accident patients
  • at least 6 months post-stroke onset
  • premorbid right-hand dominance
  • demonstration of Brunnstrom stage III of the affected upper extremity
  • no excessive spasticity in the joints of the affected upper extremity

Exclusion criteria

Exclusion Criteria:

  • a score of less than 24 on the Mini Mental State Exam
  • poor physical conditions that would interfere with participation
  • excessive pain in any joint that might limit participation
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Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Single (Outcomes assessor)
Enrollment
90 participants (actual)

Study arms

  • Experimental
    1

    constraint-induced therapy

    Other: Constraint-induced therapy (CIT)

  • Experimental
    2

    bilateral arm training

    Other: Bilateral arm training (BAT)

  • Experimental
    3

    combined therapy

    Other: Combined therapy (CT)

  • Active comparator
    Control intervention

    Behavioral: Control intervention

Interventions

  • OtherConstraint-induced therapy (CIT)

    restraint of the unaffected arm and practice of the affected arm

  • OtherBilateral arm training (BAT)

    bilateral symmetric, repetitive arm training

  • OtherCombined therapy (CT)

    combined different treatment approaches

  • BehavioralControl intervention

    Conventional treatment program

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What researchers measure

Primary outcomes

  1. Cortical reorganization and kinematic analysis

    Time frame: 2008-2010

Secondary outcomes

  1. clinical measures at the impairment, activity, participation levels

    Time frame: 2008-2010

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Study locations

1 site
  • Chang Gung Memorial Hospital
    Kwei-shan, Toayuan county 333, Taiwan
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References and documents

Publications

  • Wu CY, Chen YA, Lin KC, Chao CP, Chen YT. Constraint-induced therapy with trunk restraint for improving functional outcomes and trunk-arm control after stroke: a randomized controlled trial. Phys Ther. 2012 Apr;92(4):483-92. doi: 10.2522/ptj.20110213. Epub 2012 Jan 6. PubMed 22228607 ↗
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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Feb 11, 2015, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT00564005
Lead sponsor
Chang Gung Memorial Hospital
Collaborators
National Science Council, Taiwan, National Health Research Institutes, Taiwan
Responsible party
Sponsor
First posted
Nov 27, 2007
Start date
Jan 2008
Primary completion
Dec 2010
Completion
Dec 2010
Last update
Feb 11, 2015

Study contacts

Ching-yi Wu, ScD
principal investigator · Department of Occupational Therapy, Chang Gung Univ.

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Sep 2014. You cannot join it, but the record below documents what was studied.

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