An interventional study of cardiovascular exercise training and flexibility/balance control in Immune Response, sponsored by National Institute on Aging (NIA). Completed at 1 site in United States. Open to participants aged 62 Years to 82 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2009-01-27.
Sponsored by National Institute on Aging (NIA) · Not applicable, Interventional, and Treatment
The purpose of the study is to examine whether cardiovascular exercise training improves immune responses to vaccination in previously sedentary older adults.
The extent to which exercise training or long-term physical activity influences poorly regulated immune function in the elderly is unclear. Preliminary evidence suggests that exercise training may improve various immune function measures in older adults. Although such findings have the potential to be of substantial public health importance, the majority of studies have suffered from small sample sizes, inadequate measurement of physical fitness, and weak research designs.
This study is designed to overcome these limitations by employing a longitudinal randomized controlled trial examining the effect of exercise training on clinically relevant immune function measures in older adults (65-80 years). Moreover, relationships between several factors known to be altered by exercise training and changes in immune function will be assessed. As such, there are two specific aims to be addressed. In Aim 1, a 10-month exercise trial will determine whether moderate intensity aerobic exercise training can improve immune function in previously sedentary older adults. In Aim 2, the role played by physiological, behavioral, and psychosocial factors in the relationship between exercise training and improved immune function will be examined.
150 sedentary participants will be randomly assigned to either a 10-month moderate aerobic exercise training program or a sedentary control group. Clinically relevant measures of immune function including the delayed-type hypersensitivity (DTH) response to a battery of antigens and the antibody response to tetanus toxoid and influenza virus vaccination will be assessed before, during and after the intervention. We hypothesize that exercise training will result in improved immune responses including higher peak antibody titers and DTH responses, and sustained levels of protective antibodies.
National Institute on Aging (NIA) is the lead sponsor of 157 studies on the registry; 13 are open to participants now.
Of its 7 completed or terminated interventional studies of FDA-regulated products, 2 (29%) have results posted.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
a 10-month moderate aerobic exercise training program
Behavioral: cardiovascular exercise training
flexibility/balance control group
Behavioral: flexibility/balance control
antibody responses to influenza and tetanus toxoid vaccination and delayed type hypersensitivity responses to fungal antigens
Time frame: baseline, 6 and 10 months
cardiovascular fitness
psychosocial outcomes
This study is completed, as verified in Jan 2009. You cannot join it, but the record below documents what was studied.
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National Institute on Aging (NIA)