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CompletedNCT00532402Updated Oct 30, 2012

Continuous and Discontinuous Determination of Propofol Concentration in Breathing Gas

An observational study in General Anesthesia, sponsored by University of Luebeck. Completed at 2 sites in Germany. Open to participants aged 18 Years to 90 Years. Per ClinicalTrials.gov, last updated 2012-10-30.

Sponsored by University of Luebeck · Observational

Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
16
Ages
18 Years to 90 Years
Sex
All
01

Study summary

This study should compare the propofol concentration in breathing gas and in plasma (before and) after lung passage. Propofol concentrations in breathing gas are continuously measured by a sensor. For comparison a discontinuous method is used. Neurophysiologic parameters for determination of depth of anesthesia are compared to the continuous measured propofol concentration in breathing gas.

Study hypothesis: continuous measured propofol concentration in breathing gas correlates to propofol concentration in plasma and depth of anaesthesia.

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Conditions studied

  • General Anesthesia

Keywords

  • Monitoring
  • Breathing Gas
  • Propofol
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In context

Respiratory Aspiration

1,092 studies on the registry are indexed under Respiratory Aspiration; 216 are open to participants now.

This study's planned enrollment of 16 is below the median of 65 across 184 observational studies indexed under Respiratory Aspiration.

Browse Respiratory Aspiration studies →

Lead sponsor

University of Luebeck is the lead sponsor of 74 studies on the registry; 13 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
18 Years to 90 Years
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Probability sample

Study population

Patients having general anesthesia for cardiac and non-cardiac operation

Inclusion criteria

  • Patient destined for general anesthesia

Exclusion criteria

Exclusion Criteria:

  • Heart insufficiency NYHA IV
  • Allergy to propofol
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Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
16 participants (estimated)
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Study locations

2 sites
  • Dept. of Anesthesiology , UK-SH, Campus Luebeck
    Luebeck, Schleswig-Holstein D-23538, Germany
  • Dept. of Anesthesiology, UK-SH, Campus Luebeck
    Luebeck, Schleswig-Holstein D-23538, Germany
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References and documents

Publications

  • Grossherr M, Hengstenberg A, Meier T, Dibbelt L, Gerlach K, Gehring H. Discontinuous monitoring of propofol concentrations in expired alveolar gas and in arterial and venous plasma during artificial ventilation. Anesthesiology. 2006 Apr;104(4):786-90. doi: 10.1097/00000542-200604000-00024. PubMed 16571975 ↗
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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Oct 30, 2012, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT00532402
Lead sponsor
University of Luebeck
Responsible party
Martin Grossherr (Consultant, University of Luebeck) — Principal investigator
First posted
Sep 20, 2007
Start date
Sep 2007
Completion
Dec 2010
Last update
Oct 30, 2012

Study contacts

Hartmut Gehring, MD, PhD
study director · Dept of Anesthesiology, UK-SH, Campus Luebeck

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Oct 2012. You cannot join it, but the record below documents what was studied.

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