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WithdrawnNCT00526344Updated Feb 14, 2011

Bronchoscopy With Bronchial Biopsies Sub-study of: Persistence of Airway Inflammation and Remodeling in Asthma Remission

An observational study in Asthma, sponsored by Laval University. Withdrawn at 1 site in Canada. Open to participants aged 18 Years to 65 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2011-02-14.

Sponsored by Laval University · Observational

Why this study was withdrawn
No funding, study not done
Study type
Observational
Model
Case-control
Time perspective
Cross-sectional
Enrollment
36
Ages
18 Years to 65 Years
Sex
All
01

Study summary

This study aims at determining the patterns of asthma remission, the prevalence of these different patterns and the various factors associated with such remissions and possible recurrences of asthma, in order to determine the mechanisms involved in these processes.

We therefore want to document these specificities in studying biopsies of subjects in complete remission of their asthma and those in only symptomatic remission of their asthma, in comparison with mildly symptomatic asthmatic subjects and healthy controls.

Read the detailed description

Primary Outcome Measures :

Airway inflammation and remodeling: in bronchial biopsies

Secondary Outcome Measures:

Comparisons of bronchial biopsy features between groups:

  • Bronchial epithelial morphology
  • Bronchial mucosa (smooth muscle, reticular basement membrane, submucosal gland,...)
02

Conditions studied

  • Asthma

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Keywords

  • remission of asthma
03

In context

Asthma

3,920 studies on the registry are indexed under Asthma; 506 are open to participants now.

This study's planned enrollment of 36 is below the median of 150 across 970 observational studies indexed under Asthma.

Browse Asthma studies →

Lead sponsor

Laval University is the lead sponsor of 371 studies on the registry; 68 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 65 Years
Sexes eligible
All
Accepts healthy volunteers
Yes
Sampling method
Non-probability sample

Study population

Subjects with current asthma or in remission of asthma from primary care clinics will be allowed to participate to this study. Healthy subjects will also be invited by advertisements in newspapers to volunteer for this study.

Inclusion criteria

  • In remission of their asthma: absence of respiratory symptoms, no rescue asthma medication need and (for complete remission) an optimal pulmonary function (FEV1 > 90%) and normal PC20 methacholine for more than two years (with no current treatment).
  • With a proven past history of asthma from medical files (reversible airway obstruction (> 12% FEV1 after bronchodilator or 20% by other means) proven by spirometry, PEF measures or methacholine challenge according to current criteria + previous symptoms and asthma medication use), having no more asthma symptoms and not having used asthma medication for more than 2 years.
  • Agree to sign the consent form.
  • No other condition that could interfere with the study measurements.

Exclusion criteria

Exclusion Criteria:

  • Subjects using inhaled or oral anti-inflammatory agents.
  • FEV1 \< 1.2 L.
  • Unable to adhere to the protocol requirements.
  • Other current respiratory disease
  • Upper or lower respiratory tract infection or use of antibiotics \< 1 month.
  • Use of oral corticosteroids within the last 3 months.
  • Signs or symptoms of progressive or uncontrolled renal, hepatic, hematologic, endocrine, pulmonary, cardiac, neurologic or cerebral disease.
05

Study design

Observational model
Case-control
Time perspective
Cross-sectional
Enrollment
36 participants (estimated)
Biospecimen retention
Samples with dna

Groups and cohorts

  • 1

    Subjects with complete remission of asthma

  • 2

    Subjects with symptomatic remission of asthma

  • 3

    Subjects with asthma

  • 4

    Healthy controls

06

Study locations

1 site
  • Centre de Recherche, Hôpital Laval
    Québec, Quebec G1V 4G5, Canada
07

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Feb 14, 2011, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
08

Registry details

Key details

Study ID
NCT00526344
Lead sponsor
Laval University
First posted
Sep 10, 2007
Start date
Sep 2007
Completion
Mar 2011 (estimated)
Last update
Feb 14, 2011

Study contacts

Louis-Philippe Boulat, MD
principal investigator · Hôpital Laval

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is withdrawn, as verified in Feb 2011. You cannot join it, but the record below documents what was studied.

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