An interventional study of questionnaire administration and cognitive assessment in Cognitive/Functional Effects, Psychosocial Effects of Cancer and Its Treatment and Unspecified Adult Solid Tumor, Protocol Specific, sponsored by City of Hope Medical Center. Active, not recruiting at 8 sites in United States. Open to participants aged 65 Years to 120 Years. Per ClinicalTrials.gov, last updated 2026-03-27.
Sponsored by City of Hope Medical Center · Not applicable, Interventional, and Health services research
RATIONALE: A study that assesses the ability of older patients to think, learn, remember, make judgments, and carry out daily activities may help doctors plan treatment for older patients with cancer.
PURPOSE: This clinical trial is studying an assessment tool in older patients with cancer.
OBJECTIVES:
Primary
Secondary
OUTLINE: Patients undergo assessments of functional status using the Timed Up and Go Assessment (measures physical mobility) and Karnofsky Physician-Rated Performance Rating Scale; and cognition using the Blessed Orientation-Memory-Concentration Test. These assessments are performed by healthcare personnel. Body mass index and the percentage of unintentional weight loss and the number of falls in the past 6 months are also assessed.
Patients also complete the following self-administered questionnaires: Instrumental Activities of Daily Living (measures level of functioning and need for services); Activities of Daily Living (measures higher levels of physical functioning); Karnofsky Self-Reported Performance Rating Scale (related to survival and clinically significant illness); Physical Health Section of the Older American Resources and Services Questionnaire (measures comorbidity and the impact on daily activities); Hospital Anxiety and Depression Scale; Medical Outcomes Study (MOS) Social Activity Limitations Measure (measures the impact of cancer on patients' social functioning); and MOS Social Support Survey Emotional/Information and Tangible Subscales (measures perceived availability of social support).
Patients then begin planned chemotherapy.
After completion of chemotherapy (or a maximum of 12 months from study entry), patients undergo assessments and complete self-administered questionnaires as described above.
PROJECTED ACCRUAL: A total of 750 patients will be accrued for this study.
City of Hope Medical Center is the lead sponsor of 670 studies on the registry; 181 are open to participants now.
Of its 30 completed or terminated interventional studies of FDA-regulated products, 12 (40%) have results posted.
Counted across the registry records on this site, refreshed daily.
DISEASE CHARACTERISTICS:
Pathologically confirmed cancer
PATIENT CHARACTERISTICS:
PRIOR CONCURRENT THERAPY:
Other: questionnaire administration · Procedure: cognitive assessment · Procedure: psychosocial assessment and care
Questionnaire administered prior to chemotherapy and within 30 days of completion of chemotherapy.
Cognitive assessment to be obtained prior to chemotherapy and within 30 days of completion of chemotherapy.
Psychosocial assessment and care to be obtained prior to chemotherapy and within 30 days of completion of chemotherapy.
Ability to predict toxicity to chemotherapy, defined as grade 3-4 toxicity, hospitalization, dose delay or reduction, or discontinuation of chemotherapy due to toxicity, as measured by a geriatric assessment tool
Time frame: Prior to chemotherapy and within 30 days of completion of chemotherapy.
Longitudinal impact of cancer and chemotherapy treatment on geriatric assessment parameters
Time frame: Prior to chemotherapy and within 30 days of completion of chemotherapy.
This study is active, not recruiting, as verified in Mar 2026. You cannot join it, but the record below documents what was studied.
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City of Hope Medical Center