A Phase 3 interventional study of Minds in Motion in Cognition and Aging, sponsored by National Institute on Aging (NIA). Completed at 1 site in United States. Open to participants aged 60 Years to 74 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2009-12-11.
Sponsored by National Institute on Aging (NIA) · Phase 3, Interventional, and Treatment
The purpose of this study is to assess the effect of aerobic exercise on the brain and cognition through the measurement of neuroelectric and behavioral indices of executive control cognitive function in older adults.
The aim of this research is to gain a better understanding of factors that relate to the increased health and effective functioning of older adults. Specifically, efficiency of psychomotor performance declines with advancing age leading to profound effects on older adults' quality of life. For this reason, researchers have focused on the influence that individual lifestyle habits have on the aging process. One lifestyle choice that has been found to positively contribute to the efficiency of older adults' psychomotor performance is cardiovascular exercise. This relationship appears to be especially significant when older adults are challenged with more complex or effortful tasks. Previous research has led investigators to believe that aging has a specific, rather than generalized, impact on cognitive functioning. Also, prolonged participation in cardiovascular exercise has been found to maintain the cognitive functioning critical for healthy aging.
Therefore, the purpose of this research is to examine the role of an organized 6-month cardiovascular exercise intervention trial on electrocortical (event-related brain potential) and behavioral measures (reaction time) of executive control. In addition, a non-cardiovascular exercise control group that participates in a 6-month stretching and toning program will be used for comparison. Participants will be measured before and after exercise training during engagement in several tasks designed to elicit different executive functions (e.g., discrimination, task switching, inhibition). Each task also contains a non-executive condition that will be used for comparison to examine the specificity of exercise participation of cognitive functioning. A secondary aim of this project is to determine the effects of an acute bout of exercise on cognitive functioning. Both groups will participate in several bouts of exercise followed by immediate measurement on the tasks outlined above to determine whether acute exercise has beneficial effects on executive processes. The significance of this research may include the increased understanding of factors related to the amelioration of age-related decrements in central nervous system functioning and recommendations for the maintenance of cognitive health during the later stages of life.
National Institute on Aging (NIA) is the lead sponsor of 157 studies on the registry; 13 are open to participants now.
Of its 7 completed or terminated interventional studies of FDA-regulated products, 2 (29%) have results posted.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Changes in event-related brain potentials
reaction time
response accuracy
aerobic fitness
This study is completed, as verified in Aug 2008. You cannot join it, but the record below documents what was studied.
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National Institute on Aging (NIA)