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CompletedNCT00409123Updated Sep 26, 2008

Effect of Systemic Cooling in Vasospasms

An observational study in Vasospastic Syndrome, sponsored by University Hospital, Basel, Switzerland. Completed at 1 site in Switzerland. Open to female participants aged 19 Years to 35 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2008-09-26.

Sponsored by University Hospital, Basel, Switzerland · Observational

Study type
Observational
Model
Case-only
Time perspective
Prospective
Enrollment
28
Ages
19 Years to 35 Years
Sex
Female
01

Study summary

This study tests whether women with Vasospastic Syndrome (VS) react more intensive than controls with distal vasomotions and choroidal blood flow changes to internal cooling/warming and external cooling/warming.

Read the detailed description

Distal vasomotions and choroidal blood flow changes to internal cooling/warming and external cooling/warming was studied in VS and controls.Core cooling was induced by drinking of 250g ice/water mixture (4°C). Core warming was induced by drinking of 250g warm water (55°C). The study was controlled with respect to posture and room temperature.

02

Conditions studied

  • Vasospastic Syndrome

Keywords

  • vasospastic women
  • controls
  • core cooling
  • core warming
  • external cooling
  • external warming
  • LDF
  • choroidal blood flow
  • temperature
  • vasospastic subjects
  • normal subjects
03

In context

Lead sponsor

University Hospital, Basel, Switzerland is the lead sponsor of 968 studies on the registry; 191 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
19 Years to 35 Years
Sexes eligible
Female
Accepts healthy volunteers
Yes
Sampling method
Non-probability sample

Study population

vasospastic women

Inclusion criteria

  • women
  • luteal phase or contraceptives
  • 19-35 years

Exclusion criteria

Exclusion Criteria:

  • somatic diseases
  • psychiatric diseases
  • BMI > 25
  • BMI \< 18
05

Study design

Observational model
Case-only
Time perspective
Prospective
Enrollment
28 participants (actual)
06

What researchers measure

Primary outcomes

  1. LDF blood flow

    Time frame: repeated after each challenge

  2. LDF velocity

    Time frame: repeated after each challenge

  3. finger skin temperature

    Time frame: repeated after each challenge

  4. core body temperature

    Time frame: repeated after each challenge

  5. corneal temperature

    Time frame: repeated after each challenge

Secondary outcomes

  1. subjective sleepiness

    Time frame: repeated after each challenge

  2. subjective ratings of thermal comfort

    Time frame: repeated after each challenge

07

Study locations

1 site
  • University Eye Clinic
    Basel, 4056, Switzerland
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Sep 26, 2008, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT00409123
Lead sponsor
University Hospital, Basel, Switzerland
First posted
Dec 8, 2006
Start date
Sep 2004
Primary completion
May 2006
Completion
Jun 2006
Last update
Sep 26, 2008

Study contacts

Selim Orguel, MD
study director · Unversity Eye Clinic Basel

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Sep 2008. You cannot join it, but the record below documents what was studied.

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