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CompletedNCT00398229Updated Jan 1, 2009

hCG Supplementation in Frozen-Thawed Embryo Transfer Cycle

A Phase 2 interventional study of s.c. human chorionic gonadotropin (Ovitrelle) in Fertility Agents, Female, sponsored by Hadassah Medical Organization. Completed at 1 site in Israel. Open to female participants aged 18 Years to 45 Years. Per ClinicalTrials.gov, last updated 2009-01-01.

Sponsored by Hadassah Medical Organization · Phase 2, Interventional, and Treatment

Phase
Phase 2
Study type
Interventional
Enrollment
300
Allocation
Randomized
Ages
18 Years to 45 Years
Sex
Female
01

Study summary

The implantation rate after frozen-thawed embryo transfer cycles depends mostly on the receptivity of the endometrium and the embryo quality.The effects of human chorionic gonadotropins (hCG) on the endometrium have been investigated for several years. hCG was shown to up-regulate gene expression during the differentiation of human endometrial stromal cells into decidua. The aim of our study was to assess the benefit of hCG supplementation throughout the secretory phase of artificial frozen-thawed embryo transfer cycles.

02

Conditions studied

  • Fertility Agents, Female

Keywords

  • In-Vitro Fertilization
  • human chorionic gonadotropin
  • frozen-thawed embryo transfer
  • implantation rate
03

In context

Lead sponsor

Hadassah Medical Organization is the lead sponsor of 660 studies on the registry; 54 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 45 Years
Sexes eligible
Female
Accepts healthy volunteers
No

Inclusion criteria

  • all women on frozen-thawed embryo-transfer cycle

Exclusion criteria

Exclusion Criteria:

  • any allergy to injection of human chorionic gonadotropin before
05

Study design

Phase
Phase 2
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
None (open label)
Enrollment
300 participants (estimated)

Study arms

  • Active comparator
    A

    receiving hCG injection

    Drug: s.c. human chorionic gonadotropin (Ovitrelle)

  • Placebo comparator
    B

    Drug: s.c. human chorionic gonadotropin (Ovitrelle)

Interventions

  • Drugs.c. human chorionic gonadotropin (Ovitrelle)

    S.C. Ovitrelle 250 mcg once

06

What researchers measure

Primary outcomes

  1. implantation rate

    Time frame: 4 weeks

  2. pregnancy rate

    Time frame: 4 weeks

07

Study locations

1 site
  • Hadassah Medical center
    Jerusalem, Israel
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jan 1, 2009, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT00398229
Lead sponsor
Hadassah Medical Organization
First posted
Nov 10, 2006
Start date
Nov 2006
Completion
May 2008
Last update
Jan 1, 2009

Study contacts

Assaf Ben-Meir, MD
principal investigator · Hadassah Medical Organization
View the source record on ClinicalTrials.gov ↗

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This study is completed, as verified in Nov 2007. You cannot join it, but the record below documents what was studied.

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