An observational study in Interhemispheric Inhibition, sponsored by National Institute of Neurological Disorders and Stroke (NINDS). Completed at 1 site in United States. Open to participants aged 18 Years to 40 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2017-07-02.
Sponsored by National Institute of Neurological Disorders and Stroke (NINDS) · Observational
This study will examine how the two sides of the brain interact when learning precision hand movements. Both sides of the brain are active when a person performs an accurate hand movement. This study will look at the extent to which the two brain hemispheres interact when learning accurate hand movements.
Healthy, right-handed normal volunteers 18 - 40 years of age may be eligible for this study. Candidates are screened with a clinical and neurological examination.
Participants are randomly assigned to one of two groups - precision or non-precision hand movements. All participants undergo the following procedures:
The study involves six sessions. Sessions 1-5 are on consecutive days; session 6 is one week after session 5.
The purpose of this protocol is to investigate the changes in interhemispheric inhibition (IHI) between human motor cortices with learning of performance of an accurate motor task (pinch force control). Performing a simple motor task is associated with activation in the contralateral motor areas. Activation of the ipsilateral motor/premotor cortex might be elicited by performing more challenging and difficult unimanual motor tasks. However, the functional role played by this ipsilateral activation has been controversial, and is felt to be more prominent with more complex tasks. Several studies using paired-pulse transcranial magnetic stimulation (TMS) revealed a significant IHI from the active upon the non-active hemisphere. Together these results suggested IHI between motor cortical areas may play a critical role in motor control and could influence manual dexterity. Taking these into account, it raises the interesting question of whether the IHI balance between both motor cortices is progressively modified during the learning phase of an accurate motor task. We hypothesize that learning to perform a tracking motor task requiring accurate control of pinch force generation (Tracking accurate), will increase IHI from the "learning" to the "non-learning" hemisphere to a larger extent than learning to perform a less precise tracking motor task (Tracking non-accurate). The primary outcome measure will be the amount of changes in IHI from the "learning" to the "non-learning" hemisphere as a function of learning both motor tasks.
National Institute of Neurological Disorders and Stroke (NINDS) is the lead sponsor of 592 studies on the registry; 56 are open to participants now.
Of its 18 completed or terminated interventional studies of FDA-regulated products, 8 (44%) have results posted.
Counted across the registry records on this site, refreshed daily.
Healthy volunteers will be eligible for the study if they are:
EXCLUSION CRITERIA
Healthy volunteers will not be eligible for the study if they:
This study is completed, as verified in Jan 2009. You cannot join it, but the record below documents what was studied.
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National Institute of Neurological Disorders and Stroke (NINDS)