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CompletedNCT00285610Updated Nov 18, 2014

Early Exposure to Lead and Adult Antisocial Outcomes

An observational study in Lead Poisoning, sponsored by National Institute of Environmental Health Sciences (NIEHS). Completed at 1 site in United States. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2014-11-18.

Sponsored by National Institute of Environmental Health Sciences (NIEHS) · Observational

Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
225
Ages
18 Years and older
Sex
All
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Study summary

Prior research indicates a link between early lead exposure and risk for delinquent behavior. In this study, we follow a large birth cohort from the Cincinnati Lead Study into early adulthood to determine whether this increased risk persists. Outcome measures include official arrest records, diagnoses of Substance Abuse Disorder and Antisocial Personality Disorder, self-report of delinquent behavior, and a psychopathy scale. Predictors include pre-natal and post-natal blood lead levels. Multivariate statistical methods will control for potential confounders/covariates.

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Conditions studied

  • Lead Poisoning

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In context

Lead Poisoning

27 studies on the registry are indexed under Lead Poisoning; 2 are open to participants now.

This study's planned enrollment of 225 is below the median of 350 across 14 observational studies indexed under Lead Poisoning.

Browse Lead Poisoning studies →

Lead sponsor

National Institute of Environmental Health Sciences (NIEHS) is the lead sponsor of 183 studies on the registry; 18 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

Pregnant women were recruited from four prenatal clinics in Cincinnati, Ohio if they resided in areas of the city with a high concentration of older, lead-contaminated housing

Eligibility criteria

Inclusion Criteria: (1) Part of original CLS birth cohort -

Exclusion Criteria: (1) Moved out of geographic area

-

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Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
225 participants (estimated)
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What researchers measure

Primary outcomes

  1. Lead Exposure and Antisocial Behavior

    Time frame: Prenatal (1-2 trimester) and postnatal on a quarterly and bi-annual basis (until 6.5 years)

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Study locations

1 site
  • Children's Hospital Medical Center
    Cincinnati, Ohio 45229, United States
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Timeline

Tracking since Sep 25, 2026
Not marked actual or estimatedDates not marked actual or estimated

The record gives a start of Nov 2001, a primary completion of Oct 2006 and a completion of Oct 2006. It does not say whether these dates are actual or estimated.

How these figures are worked out, and which studies are left out of them.

Registered
Feb 1, 2006
First posted
Feb 2, 2006
Start
Nov 2001
Primary completionActual
Oct 2006
CompletionActual
Oct 2006
Last update
Nov 18, 2014
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.
When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.
When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
No changes since tracking began. The registry record was last updated on Nov 18, 2014, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT00285610
Responsible party
Sponsor
First posted
Feb 2, 2006
Start date
Nov 2001
Primary completion
Oct 2006
Completion
Oct 2006
Last update
Nov 18, 2014

Study contacts

M. Douglas Ris, Ph.D.
principal investigator · Children's Hospital Medical Center, Cincinnati
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Nov 2014. You cannot join it, but the record below documents what was studied.

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