CClinicalTrials.gg
TerminatedNCT00280085Updated Aug 7, 2009

The Aim is to Estimate the Total Amount of Insulin-producing Cells in the Pancreas by MRI.

An interventional study of MR imaging and Glucose clamp in Diabetes Mellitus, sponsored by Pfizer. Terminated at 1 site in United States. Open to participants aged 18 Years to 65 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2009-08-07.

Sponsored by Pfizer · Not applicable, Interventional, and Diagnostic

Why this study was terminated
Explanation provided in detailed descriptiong section of record.
Phase
Not applicable
Study type
Interventional
Enrollment
29
Allocation
Non-randomized
Ages
18 Years to 65 Years
Sex
All
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Study summary

Assess pancreatic beta cell function using MR imaging.

Read the detailed description

The study was terminated on July 31st, 2007. The study was discontinued, as we have not met the primary end point, differentiation between normal volunteers and subjects with type 1 diabetes mellitus. There were no safety concerns.

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Conditions studied

  • Diabetes Mellitus

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03

In context

Diabetes Mellitus

10,925 studies on the registry are indexed under Diabetes Mellitus; 1,319 are open to participants now.

This study's enrollment of 29 is below the median of 80 across 8,367 interventional studies indexed under Diabetes Mellitus.

Browse Diabetes Mellitus studies →

Lead sponsor

Pfizer is the lead sponsor of 3,244 studies on the registry; 139 are open to participants now.

Of its 582 completed or terminated interventional studies of FDA-regulated products, 381 (65%) have results posted.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
18 Years to 65 Years
Sexes eligible
All
Accepts healthy volunteers
Yes

Inclusion criteria

  • Normal Volunteers
  • T1DM and T2DM subjects

Exclusion criteria

Exclusion Criteria:

  • Concomitant severe conditions
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Study design

Phase
Not applicable
Primary purpose
Diagnostic
Allocation
Non-randomized
Intervention model
Single group
Masking
None (open label)
Enrollment
29 participants (actual)

Interventions

  • ProcedureMR imaging
  • ProcedureGlucose clamp
  • DrugArginine

    Also known as: R-Gene 10

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What researchers measure

Primary outcomes

  1. Pancreatic perfusion

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Study locations

1 site
  • Pfizer Investigational Site
    New Haven, Connecticut 06510, United States
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References and documents

Publications

  • Hirshberg B, Qiu M, Cali AM, Sherwin R, Constable T, Calle RA, Tal MG. Pancreatic perfusion of healthy individuals and type 1 diabetic patients as assessed by magnetic resonance perfusion imaging. Diabetologia. 2009 Aug;52(8):1561-5. doi: 10.1007/s00125-009-1406-8. Epub 2009 Jun 3. PubMed 19488737 ↗
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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Aug 7, 2009, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT00280085
Lead sponsor
Pfizer
Collaborators
Yale University
First posted
Jan 20, 2006
Start date
Dec 2005
Completion
Jul 2007
Last update
Aug 7, 2009

Study contacts

Pfizer CT.gov Call Center
study director · Pfizer
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is terminated, as verified in Sep 2008. You cannot join it, but the record below documents what was studied.

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