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CompletedNCT00279656Updated Jan 19, 2006

Benefit of a Collaborative Approach to Improve the Quality of Medicines Use in Elderly Inpatients

A Phase 4 interventional study of Pharmaceutical care in Frail Elderly Inpatient, sponsored by Université Catholique de Louvain. Completed at 1 site in Belgium. Open to participants aged 70 Years and older. Per ClinicalTrials.gov, last updated 2006-01-19.

Sponsored by Université Catholique de Louvain · Phase 4, Interventional, and Educational/counseling/training

Phase
Phase 4
Study type
Interventional
Enrollment
180
Allocation
Randomized
Ages
70 Years and older
Sex
All
01

Study summary

The purpose of this study is to evaluate the impact of a collaborative approach (geriatric care involving the collaboration with a clinical pharmacist) to optimize the prescription of medicines for elderly inpatients.

Read the detailed description

Widespread evidence reveals frequent inadequate use of medicines in elderly patients. This includes inappropriate prescribing (overuse, underuse, misuse) that can lead to adverse drug events and drug-related admissions to hospital. In addition, when a patient is transferred from acute care settings to ambulatory care settings, discrepancies in medicines used often occur and can be hazardous.

Despite this, only limited data exist on the effectiveness of optimization strategies targeted at frail elderly inpatients.

Comparison: elderly inpatients receiving geriatric evaluation and management (GEM) care versus elderly inpatients receiving pharmaceutical care in addition to GEM care.

02

Conditions studied

  • Frail Elderly Inpatient

Keywords

  • Frail elderly
  • Pharmaceutical services
  • Drug therapy
  • Geriatrics
  • Randomized controlled trial
  • Hospitals, teaching
03

In context

Lead sponsor

Université Catholique de Louvain is the lead sponsor of 144 studies on the registry; 57 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
70 Years and older
Sexes eligible
All
Accepts healthy volunteers
No

Eligibility criteria

Inclusion Criteria:

  • Patient admitted on the acute geriatric unit of the university teaching hospital Mont-Godinne, Belgium

Exclusion Criteria:

  • a terminal illness and life expectancy of less than 3 month
  • expected length of stay of 2 days or less
  • transfer from another unit where the patient had already been cared for by a GEM team
  • refusal to participate
  • inclusion during previous admission
  • no time for the clinical pharmacist to compound the abstracted chart within 3 days of admission
05

Study design

Phase
Phase 4
Primary purpose
Educational/counseling/training
Allocation
Randomized
Intervention model
Parallel assignment
Masking
None (open label)
Enrollment
180 participants

Interventions

  • BehavioralPharmaceutical care
06

What researchers measure

Primary outcomes

  1. Appropriateness of prescribing (using the Medication Appropriateness Index, the Beers criteria, and the ACOVE criteria of underuse) on admission, at discharge, and 3 months post-discharge

Secondary outcomes

  1. Polymedication on admission, at discharge, and 1,3,12 months after discharge

  2. Mortality, readmission to hospital and visit to the emergency department 1,3,12 months after discharge

  3. Satisfaction with information received on medicines

07

Study locations

1 site
  • Université catholique de Louvain
    Brussels, 1200, Belgium
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jan 19, 2006, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT00279656
Lead sponsor
Université Catholique de Louvain
Collaborators
Fonds National de la Recherche Scientifique
First posted
Jan 19, 2006
Start date
Nov 2003
Completion
Jun 2005
Last update
Jan 19, 2006

Study contacts

Anne Spinewine, MSc
principal investigator · Université Catholique de Louvain
Christian Swine, MD
study chair · Université Catholique de Louvain
Paul M Tulkens, PhD
study director · Université Catholique de Louvain
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Jun 2004. You cannot join it, but the record below documents what was studied.

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