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CompletedNCT00212537Updated Aug 30, 2022

Disease Modifying Genes in Severe Asthma

An observational study in Asthma, sponsored by NYU Langone Health. Completed at 1 site in United States. Open to participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2022-08-30.

Sponsored by NYU Langone Health · Observational

Study type
Observational
Model
Case-control
Time perspective
Other
Enrollment
941
Ages
18 Years and older
Sex
All
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Study summary

Gene and protein bank to study disease modifying and susceptibility genes and proteins in urban patients with asthma.

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Conditions studied

  • Asthma

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Keywords

  • Asthma and normal
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In context

Asthma

4,012 studies on the registry are indexed under Asthma; 514 are open to participants now.

This study's enrollment of 941 is above the median of 150 across 993 observational studies indexed under Asthma.

Browse Asthma studies →

Lead sponsor

NYU Langone Health is the lead sponsor of 1,421 studies on the registry; 254 are open to participants now.

Of its 231 completed or terminated interventional studies of FDA-regulated products, 195 (84%) have results posted.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
Yes
Sampling method
Non-probability sample

Study population

All individuals approached for participation in the Research Registry shall be able to read or comprehend English. Since participation in the Research Registry does not involve a risk of physical harm, women of childbearing potential will not be queried as to pregnancy status or tested for pregnancy unless they are requested to undergo a methacholine challenge test. There are no additional inclusion/exclusion criteria.

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Ages 18 and above

Exclusion criteria

Exclusion Criteria:

  • Greater than 10 pack year tobacco history
  • Lung diseases other than asthma
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Study design

Observational model
Case-control
Time perspective
Other
Enrollment
941 participants (actual)
Biospecimen retention
Samples with dna
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What researchers measure

Primary outcomes

  1. To recruit and characterize a cohort of subjects with asthma who reside in a high pollution, high asthma risk neighborhood

    Time frame: five yeARS

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Study locations

1 site
  • NYU School of Medicine
    New York, New York 10016, United States
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References and documents

Publications

  • Patrawalla P, Kazeros A, Rogers L, Shao Y, Liu M, Fernandez-Beros ME, Shang S, Reibman J. Application of the asthma phenotype algorithm from the Severe Asthma Research Program to an urban population. PLoS One. 2012;7(9):e44540. doi: 10.1371/journal.pone.0044540. Epub 2012 Sep 13. PubMed 23028556 ↗
  • Liu M, Rogers L, Cheng Q, Shao Y, Fernandez-Beros ME, Hirschhorn JN, Lyon HN, Gajdos ZK, Vedantam S, Gregersen P, Seldin MF, Bleck B, Ramasamy A, Hartikainen AL, Jarvelin MR, Kuokkanen M, Laitinen T, Eriksson J, Lehtimaki T, Raitakari OT, Reibman J. Genetic variants of TSLP and asthma in an admixed urban population. PLoS One. 2011;6(9):e25099. doi: 10.1371/journal.pone.0025099. Epub 2011 Sep 22. PubMed 21966427 ↗
  • Reibman J, Marmor M, Filner J, Fernandez-Beros ME, Rogers L, Perez-Perez GI, Blaser MJ. Asthma is inversely associated with Helicobacter pylori status in an urban population. PLoS One. 2008;3(12):e4060. doi: 10.1371/journal.pone.0004060. Epub 2008 Dec 29. PubMed 19112508 ↗
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Timeline

Tracking since Sep 25, 2026
ElapsedEstimatedEstimated, not yet reachedSimilar studies: half by the dot; the band is the middle halfHalf of similar studies reached it by the dot; the band is the middle half, from a quarter to three quarters

Ran from Apr 2002 to primary completion in Jan 2011, 105 months.

Of 311 non-industry observational studies under Asthma, half reached primary completion within 38 months of starting (the median), counting those still running; a quarter within 18 and three quarters within 100. This study's 105 months is above that.

Counting every sponsor, half of 387 studies reached it within 35 months; a quarter within 18 and three quarters within 84.

How these figures are worked out, and which studies are left out of them.

Registered
Sep 19, 2005
First posted
Sep 21, 2005
StartActual
Apr 8, 2002
Primary completionActual
Jan 13, 2011
CompletionActual
Jul 23, 2019
Last update
Aug 30, 2022
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.
When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.
When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
No changes since tracking began. The registry record was last updated on Aug 30, 2022, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT00212537
Lead sponsor
NYU Langone Health
Responsible party
Sponsor
First posted
Sep 21, 2005
Start date
Apr 8, 2002
Primary completion
Jan 13, 2011
Completion
Jul 23, 2019
Last update
Aug 30, 2022

Study contacts

Joan Reibman, MD
principal investigator · NYU School of Medicine

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Aug 2022. You cannot join it, but the record below documents what was studied.

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