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CompletedNCT00187239Updated Feb 4, 2019

Reduce Ventricular Pacing in Dual Chamber Implantable Cardioverter Defibrillators Using AutoIntrinsic Conduction Search Study

A Phase 4 interventional study of Autointrinsic Conduction Search Algorithm in Arrhythmia, sponsored by Abbott Medical Devices. Completed at 1 site in United States. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2019-02-04.

Sponsored by Abbott Medical Devices · Phase 4, Interventional, and Treatment

Phase
Phase 4
Study type
Interventional
Enrollment
157
Allocation
Randomized
Ages
18 Years and older
Sex
All
01

Study summary

The purpose of this study is to determine if patients implanted with a St. Jude Medical (SJM) implantable cardioverter defibrillator (ICD) will benefit by using AutoIntrinsic Conduction Search (AICS) rather than only a programmed AV/PV delay. This study will compare the two methods of programming with respect to intrinsic activity.

02

Conditions studied

  • Arrhythmia

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Keywords

  • ICDs
  • Ventricular pacing
  • Patient has been implanted with a dual chamber SJM ICD with AICS for 1 month (± 2 weeks).
  • At the time of enrollment, patient is paced in the RV ≤25% of the time as determined by the device diagnostics.
  • Patient is medically stable.
03

In context

Arrhythmias, Cardiac

885 studies on the registry are indexed under Arrhythmias, Cardiac; 235 are open to participants now.

This study's enrollment of 157 is above the median of 99 across 429 interventional studies indexed under Arrhythmias, Cardiac.

Browse Arrhythmias, Cardiac studies →

Lead sponsor

Abbott Medical Devices is the lead sponsor of 525 studies on the registry; 35 are open to participants now.

Of its 52 completed or terminated interventional studies of FDA-regulated products, 43 (83%) have results posted.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • Patient has been implanted with a dual chamber SJM ICD with AICS for 1 month (± 2 weeks).
  • At the time of enrollment, patient is paced in the right ventricle (RV) ≤25% of the time as determined by the device diagnostics.
  • Patient is medically stable.

Exclusion criteria

Exclusion Criteria:

  • Patient has evidence of atrioventricular (AV) block (first, second or third degree) such that ventricular pacing would be required as part of the patient's routine management
  • Patient is unable to comply with the follow-up visits due to geographical, psychological, or any other reasons.
  • Patient is younger than 18 years of age.
  • Patient is pregnant.
05

Study design

Phase
Phase 4
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
None (open label)
Enrollment
157 participants (actual)

Study arms

  • Active comparator
    AICS On

    Patients in this arm have Autointrinsic conduction search programmed ON.

    Device: Autointrinsic Conduction Search Algorithm

  • No intervention
    AICS Off

    Patients assigned to this arm do not have Autointrinsic Conduction Search programmed on.

Interventions

  • DeviceAutointrinsic Conduction Search Algorithm

    Autointrinsic conduction search is programmed on in those patients randomized to AICS ON.

06

What researchers measure

Primary outcomes

  1. The primary endpoint is the percentage of intrinsic ventricular events.

    Time frame: 3 months

Secondary outcomes

  1. Number of atrial tachycardia (AT), atrial fibrillation (AF), ventricular tachycardia (VT), and ventricular fibrillation (VF) episodes

    Time frame: 3 months

  2. Frequency of inappropriate ICD therapy during AT/AF

    Time frame: 3 months

  3. Frequency of appropriate ICD therapy for VT/VF

    Time frame: 3 months

  4. Study related adverse events

    Time frame: 3 months

07

Study locations

1 site
  • AtlantiCare Regional Medical Center
    Pomona, New Jersey, United States
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Feb 4, 2019, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT00187239
Lead sponsor
Abbott Medical Devices
First posted
Sep 16, 2005
Start date
Jul 2005
Primary completion
Aug 2007
Completion
Aug 2007
Last update
Feb 4, 2019

Study contacts

Zaffer Syed, MS
study director · Abbott Medical Devices
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Feb 2019. You cannot join it, but the record below documents what was studied.

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