Low-Dose Taxotere® (Docetaxel) With Concurrent Radiotherapy For Localized, Inoperable Carcinoma Of The Uterine Cervix

• Histologic confirmation of squamous, adenocarcinoma, or adenosquamous carcinoma of the uterine cervix including FIGO (International Federation of Gynecologists and Obstetricians) stage IB to IVA with or without pelvic adenopathy.
• No evidence of para-aortic or distant metastases. Must have evaluable disease.
• Zubrod Performance Status 0-2 or Karnofsky Performance Status > 60
• Laboratory values must be as follows:

White blood cell count: > 3,000/mm3,Absolute granulocyte count: > 1,500/mm3, Hemoglobin > 8.0 g/dl, Platelets: > 100,000/mm3, Serum creatinine: \< 2.5 mg/dl, Serum calcium: \< 1.3 x institutional upper normal limit,Hepatic criteria as follows: Total Bilirubin \< ULN for the institution,

• Signed study-specific informed consent p
• Age > 18 years.
• Peripheral neuropathy must be \< grade 1.

Exclusion Criteria:

• Prior or simultaneous malignancies (other than skin cancer) unless disease-free
• Medical illness preventing the use of taxane-based chemotherapy.
• Carcinoma of the cervix with the following histology: melanoma, sarcoma, small carcinoid, glassy cell, clear cell, and adenoid cystic.
• Previous or current medical or psychiatric illness that would prevent informed consent
• Patients known to be infected with HIV or a history of AIDS are excluded.
• Prior surgery for carcinoma of the cervix other than a biopsy.
• Patients with para-aortic disease.
• Previous pelvic radiation therapy or systemic chemotherapy is not permitted.
• Women who are pregnant or breast-feeding are excluded from this study.
• Previous history of hypersensitivity reaction to Taxotere or other drugs formulated with polysorbate 80 must be excluded.