A Phase 4 interventional study of Vitamin A in Mortality and Morbidity, sponsored by Bandim Health Project. Status unknown at 1 site in Guinea-Bissau. Open to participants aged 6 Months to 5 Years. Per ClinicalTrials.gov, last updated 2013-11-15.
Sponsored by Bandim Health Project · Phase 4, Interventional, and Prevention
Vitamin A supplementation (VAS) is important for the immune system and may interact with different childhood vaccinations. We have hypothesized that the improved survival after VAS may depend on vitamin A amplifying the non-specific immune modulation induced by vaccinations.
In the present study we used information collected in connection with a national vitamin A campaign in Guinea-Bissau during which different doses of VAS was provided together with missing doses of DTP, OPV, and measles vaccines. We aimed to study the potential interactions between VAS and vaccine type.
Vitamin A supplementation (VAS) acts as an adjuvant to vaccines, and VAS has been shown to enhance both cellular and humoral immune responses in animals and in humans. Routine childhood vaccinations have recently been shown to have important non-targeted effects on mortality, i.e. effects that cannot be explained merely by the prevention of the targeted disease. We have hypothesized that the improved survival after VAS may depend not only on the prevention of vitamin A deficiency, but also on vitamin A amplifying the non-specific immune modulation induced by routine vaccinations.
In the present study we used information collected in connection with a national vitamin A campaign in Guinea-Bissau during which different doses of VAS was provided together with missing doses of DTP, OPV, and measles vaccines. We aimed to study the potential interactions between VAS and vaccine type.
Bandim Health Project is the lead sponsor of 59 studies on the registry; 5 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Inclusion Criteria:Between 6 months and 5 years and thus eligible for vitamin A and missing vaccines during national immunisation days -
Exclusion Criteria: Overt signs of vitamin A deficiency
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Mortality
Morbidity
Both outcomes analysed according to vaccine received and sex
This study is status unknown, as verified in Nov 2013. You cannot join it, but the record below documents what was studied.
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Bandim Health Project