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CompletedNCT00087828Updated Aug 18, 2006

Identification of the Cranberry Juice Compounds That Prevent Urinary Tract Infections

An interventional study of Cranberry juice cocktail in Urinary Tract Infections, sponsored by National Center for Complementary and Integrative Health (NCCIH). Completed at 1 site in United States. Open to female participants aged 18 Years to 64 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2006-08-18.

Sponsored by National Center for Complementary and Integrative Health (NCCIH) · Not applicable, Interventional, and Diagnostic

Phase
Not applicable
Study type
Interventional
Enrollment
5
Allocation
Non-randomized
Ages
18 Years to 64 Years
Sex
Female
01

Study summary

The purpose of this study is to identify the substances in cranberry juice that make it effective in reducing urinary tract infections (UTIs) in women.

Read the detailed description

Urinary tract infections (UTIs) are a significant health issue, with one fourth of all women experiencing symptoms during their lifetimes. Cranberry juice has been shown to reduce the incidence of UTIs by preventing bacteria from adhering to the bladder. However, the compounds that direct this activity have not been identified. This study will identify and examine UTI-reducing compounds in cranberry juice.

Participants in this study will drink a specified amount of water following an overnight fast. Their urine will be collected 1 to 3 hours after the water is consumed. Several days later, the women will be provided with cranberry juice to replace the water in the regimen. Urine samples will be analyzed for compounds that have antibacterial or antiadhesion activity against the bacteria that cause UTIs.

02

Conditions studied

  • Urinary Tract Infections

Keywords

  • Vaccinium macrocarpon
03

In context

Infections

6,688 studies on the registry are indexed under Infections; 807 are open to participants now.

This study's enrollment of 5 is below the median of 120 across 4,201 interventional studies indexed under Infections.

Browse Infections studies →

Lead sponsor

National Center for Complementary and Integrative Health (NCCIH) is the lead sponsor of 218 studies on the registry; 7 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 64 Years
Sexes eligible
Female
Accepts healthy volunteers
Yes

Inclusion criteria

  • Good overall health

Exclusion criteria

Exclusion Criteria:

  • History of urinary tract infections
  • Use of cranberry products or antibiotics within 1 week of study start
  • Current use of any other medication
  • Hypertension
  • Diabetes
  • Pregnancy
05

Study design

Phase
Not applicable
Primary purpose
Diagnostic
Allocation
Non-randomized
Intervention model
Single group
Masking
None (open label)
Enrollment
5 participants

Interventions

  • DrugCranberry juice cocktail
06

Study locations

1 site
  • Dept Medicinal Chemistry & Pharmacognosy, COP, UIC
    Chicago, Illinois 60612, United States
07

References and documents

Publications

  • Ahuja S, Kaack B, Roberts J. Loss of fimbrial adhesion with the addition of Vaccinum macrocarpon to the growth medium of P-fimbriated Escherichia coli. J Urol. 1998 Feb;159(2):559-62. doi: 10.1016/s0022-5347(01)63983-1. PubMed 9649291 ↗
  • Avorn J, Monane M, Gurwitz JH, Glynn RJ, Choodnovskiy I, Lipsitz LA. Reduction of bacteriuria and pyuria after ingestion of cranberry juice. JAMA. 1994 Mar 9;271(10):751-4. doi: 10.1001/jama.1994.03510340041031. PubMed 8093138 ↗
  • Foo LY, Lu Y, Howell AB, Vorsa N. A-Type proanthocyanidin trimers from cranberry that inhibit adherence of uropathogenic P-fimbriated Escherichia coli. J Nat Prod. 2000 Sep;63(9):1225-8. doi: 10.1021/np000128u. PubMed 11000024 ↗
  • Foo LY, Lu Y, Howell AB, Vorsa N. The structure of cranberry proanthocyanidins which inhibit adherence of uropathogenic P-fimbriated Escherichia coli in vitro. Phytochemistry. 2000 May;54(2):173-81. doi: 10.1016/s0031-9422(99)00573-7. PubMed 10872208 ↗
  • Schmidt DR, Sobota AE. An examination of the anti-adherence activity of cranberry juice on urinary and nonurinary bacterial isolates. Microbios. 1988;55(224-225):173-81. PubMed 3063927 ↗
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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Aug 18, 2006, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT00087828
Lead sponsor
National Center for Complementary and Integrative Health (NCCIH)
First posted
Jul 16, 2004
Start date
Nov 2000
Completion
Jun 2005
Last update
Aug 18, 2006

Study contacts

Susan Turner, MD
principal investigator · UIC
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Aug 2006. You cannot join it, but the record below documents what was studied.

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