CClinicalTrials.gg
TerminatedNCT00080509Updated Feb 3, 2010

Effectiveness of KOS-862 in the Treatment of Lung Cancer

A Phase 2 interventional study of KOS-862 in Lung Cancer, sponsored by Bristol-Myers Squibb. Terminated. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2010-02-03.

Sponsored by Bristol-Myers Squibb · Phase 2, Interventional, and Treatment

Phase
Phase 2
Study type
Interventional
Enrollment
85
Allocation
Non-randomized
Ages
18 Years and older
Sex
All
01

Study summary

The purpose of this study is to determine whether a potential drug known as KOS-862 or "Epothilone D" has an effect as a 2nd line treatment in non-small cell lung cancer (NSCLC) for patients having failed one prior platinum-containing chemotherapy regimen.

Read the detailed description

To determine the antitumor activity, based on the confirmed objective response rate, of KOS-862, administered intravenously weekly for 3 weeks every 4 weeks, in patients with non-small cell lung cancer (NSCLC) whose disease has progressed following initial chemotherapy for advanced or metastatic disease.

02

Conditions studied

  • Lung Cancer

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03

In context

Lung Neoplasms

7,243 studies on the registry are indexed under Lung Neoplasms; 1,557 are open to participants now.

This study's enrollment of 85 is above the median of 60 across 5,295 interventional studies indexed under Lung Neoplasms.

Browse Lung Neoplasms studies →

Lead sponsor

Bristol-Myers Squibb is the lead sponsor of 1,538 studies on the registry; 116 are open to participants now.

Of its 429 completed or terminated interventional studies of FDA-regulated products, 223 (52%) have results posted.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • At least 18 years of age
  • Measurable disease
  • One previous treatment of a platinum based drug such as cisplatin or carboplatin
  • At least 3 weeks since last surgery/radiation/chemotherapy

Exclusion criteria

Exclusion Criteria:

  • Brain metastases
  • Changes in the rhythm of your heart that are considered significant as determined by an ECG tracing
05

Study design

Phase
Phase 2
Primary purpose
Treatment
Allocation
Non-randomized
Intervention model
Single group
Masking
None (open label)
Enrollment
85 participants

Interventions

  • DrugKOS-862
06

What researchers measure

Primary outcomes

  1. NSCLC

07

Study locations

No study locations are listed for this record.

08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Feb 3, 2010, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT00080509
Lead sponsor
Bristol-Myers Squibb
First posted
Apr 7, 2004
Start date
Dec 2003
Completion
Nov 2004
Last update
Feb 3, 2010
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is terminated, as verified in Nov 2009. You cannot join it, but the record below documents what was studied.

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