An observational study in Lead Poisoning and Infertility, sponsored by National Institute of Environmental Health Sciences (NIEHS). Completed. Open to participants aged 20 Years to 34 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2006-03-23.
Sponsored by National Institute of Environmental Health Sciences (NIEHS) · Observational
This prospective cohort study of 400 lead exposed and 400 non-lead exposed women and their husbands assesses endocrine dysfunction and adverse reproductive outcomes. Residing in two study areas in Shenyang, China, the women are married, 20 and 34 years of age, never smokers, have obtained permission to have a child, and have attempted to become pregnant over the course of the study. Lead exposure is defined by lead levels in blood samples collected at the baseline survey (both women and their husbands), first and second trimesters, and at delivery (both maternal and cord blood). Endocrine dysfunction is monitored by urinary hormone metabolites including follicle-stimulating hormone (FSH), luteinizing hormone (LH), estrone conjugates (E1C), and pregnanediol-3-glucuronide (PdG). Reproductive endpoints include menstrual disturbance, time to conception, spontaneous abortion, preterm delivery, and low birth weight.
27 studies on the registry are indexed under Lead Poisoning; 2 are open to participants now.
This study's enrollment of 800 is above the median of 350 across 14 observational studies indexed under Lead Poisoning.
Browse Lead Poisoning studies →National Institute of Environmental Health Sciences (NIEHS) is the lead sponsor of 183 studies on the registry; 18 are open to participants now.
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This study is completed, as verified in Mar 2006. You cannot join it, but the record below documents what was studied.
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National Institute of Environmental Health Sciences (NIEHS) →