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CompletedNCT00013858Updated Apr 14, 2015

Environmental Contaminants and Infant Development

An observational study in Mercury Poisoning and Lead Poisoning, sponsored by National Institute of Environmental Health Sciences (NIEHS). Completed at 1 site in Canada. Open to participants aged 1 Day to 1 Day, including healthy volunteers. Per ClinicalTrials.gov, last updated 2015-04-14.

Sponsored by National Institute of Environmental Health Sciences (NIEHS) · Observational

Study type
Observational
Time perspective
Prospective
Enrollment
280
Ages
1 Day to 1 Day
Sex
All
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Study summary

This study is designed to examine the effects of prenatal exposure to environmental contaminants on cognitive and behavioral development and physical growth in two groups of Inuit infants-one in Northern Quebec; the other in Greenland.

Read the detailed description

Due to prevailing weather patterns and ocean currents, certain environmental contaminants are transported to the Arctic region. The Inuit are among the most heavily exposed populations on earth due to the prevalence of these contaminants in traditional foods that comprise a large portion of their diet. The contaminants assessed in this study include polychlorinated biphenyls (PCBs), methylmercury, selenium, organochlorine pesticides, and lead. These contaminants are measured in umbilical cord blood samples obtained at birth, milk samples obtained from breast-feeding mothers and, in the case of mercury, hair samples obtained from the mothers. Omega-3 and omega-6 fatty acids are also assessed in these samples to examine the degree to which these nutrients may protect against adverse effects attributable to these contaminants.

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Conditions studied

  • Mercury Poisoning
  • Lead Poisoning

Keywords

  • methylmercury
  • PCBs
  • lead
  • fish consumption
  • breast-feeding
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In context

Lead Poisoning

27 studies on the registry are indexed under Lead Poisoning; 2 are open to participants now.

This study's planned enrollment of 280 is below the median of 350 across 14 observational studies indexed under Lead Poisoning.

Browse Lead Poisoning studies →

Lead sponsor

National Institute of Environmental Health Sciences (NIEHS) is the lead sponsor of 183 studies on the registry; 18 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
1 Day to 1 Day
Sexes eligible
All
Accepts healthy volunteers
Yes

Eligibility criteria

infant born during recruitment period to a mother who is a resident of Povungnituk, Inukjuak, and Kuujjuarapik, Quebec or Nuuk, Greenland

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Study design

Time perspective
Prospective
Enrollment
280 participants (estimated)
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Study locations

1 site
  • Public Health Centre of Quebec
    Beauport, Quebec, Canada
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References and documents

Publications

  • Dewailly, E., Bruneau, S., Ayotte, P., Liliberte, C., Gingras, S. Belander, D. and Ferron, L. Health status at birth of Inuit newborn prenatally exposed to organochlorines - Chemosphre, 1993, 27: 359-366.
  • Dewailly E, Ayotte P, Bruneau S, Laliberte C, Muir DC, Norstrom RJ. Inuit exposure to organochlorines through the aquatic food chain in arctic quebec. Environ Health Perspect. 1993 Dec;101(7):618-20. doi: 10.1289/ehp.93101618. PubMed 8143594 ↗
  • Jacobson SW, Fein GG, Jacobson JL, Schwartz PM, Dowler JK. The effect of intrauterine PCB exposure on visual recognition memory. Child Dev. 1985 Aug;56(4):853-60. PubMed 3930167 ↗
  • Jacobson JL, Jacobson SW. Intellectual impairment in children exposed to polychlorinated biphenyls in utero. N Engl J Med. 1996 Sep 12;335(11):783-9. doi: 10.1056/NEJM199609123351104. PubMed 8703183 ↗
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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Apr 14, 2015, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT00013858
Collaborators
Indian and Northern Affairs, Canada, Health Canada, Danish Institute for Public Health
First posted
Apr 3, 2001
Start date
Jan 1997
Primary completion
Aug 2011
Completion
Aug 2011
Last update
Apr 14, 2015
View the source record on ClinicalTrials.gov ↗

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This study is completed, as verified in Apr 2015. You cannot join it, but the record below documents what was studied.

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