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CompletedNCT00000830Updated Jun 24, 2005

Intracellular Pharmacokinetics of Zidovudine Triphosphate in Maternal and Infant Cord Blood Mononuclear Cells.

An observational study in HIV Infections and Pregnancy, sponsored by National Institute of Allergy and Infectious Diseases (NIAID). Completed at 6 sites in 2 countries. Open to female participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2005-06-24.

Sponsored by National Institute of Allergy and Infectious Diseases (NIAID) · Observational

Study type
Observational
Model
Natural history
Enrollment
24
Ages
18 Years and older
Sex
Female
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Study summary

To determine the levels of zidovudine triphosphate ( AZT-TP ) in maternal and fetal cord blood mononuclear cells. To determine the ratio of AZT-TP to endogenous nucleoside triphosphate levels in maternal and fetal cells. To determine the extent of drug transfer through the feto/placental unit.

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Conditions studied

  • HIV Infections
  • Pregnancy

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In context

HIV Infections

4,257 studies on the registry are indexed under HIV Infections; 240 are open to participants now.

This study's enrollment of 24 is below the median of 200 across 713 observational studies indexed under HIV Infections.

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Lead sponsor

National Institute of Allergy and Infectious Diseases (NIAID) is the lead sponsor of 2,401 studies on the registry; 179 are open to participants now.

Of its 396 completed or terminated interventional studies of FDA-regulated products, 294 (74%) have results posted.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
18 Years and older
Sexes eligible
Female
Accepts healthy volunteers
No
This record does not list eligibility criteria. Contact the study team before assuming you do or do not qualify.
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Study design

Observational model
Natural history
Enrollment
24 participants
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Study locations

6 sites
  • Univ of Medicine & Dentistry of New Jersey / Univ Hosp
    Newark, New Jersey 071032714, United States
  • Bellevue Hosp / New York Univ Med Ctr
    New York, New York 10016, United States
  • Mount Sinai Med Ctr / Pediatrics
    New York, New York 10029, United States
  • Regional Med Ctr at Memphis
    Memphis, Tennessee 38103, United States
  • Saint Jude Children's Research Hosp of Memphis
    Memphis, Tennessee 381052794, United States
  • San Juan City Hosp
    San Juan, 009367344, Puerto Rico
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References and documents

Publications

  • Rodman JH, Flynn PM, Robbins BL, Blanchard S, Jimenez E, Rodriguez J, Fridland A. Zidovudine pharmacokinetics and intracellular pharmacology of zidovudine in HIV-infected women and newborn infants. Conf Retroviruses Opportunistic Infect. 1999 Jan 31-Feb 4;6th:146 (abstract no 419)
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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jun 24, 2005, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT00000830
Lead sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
First posted
Aug 31, 2001
Last update
Jun 24, 2005

Study contacts

Fridland A
study chair
Flynn P
study chair
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Mar 1998. You cannot join it, but the record below documents what was studied.

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