Yale University: Alcoholism trials

The registry lists 88 Alcoholism studies with Yale University as lead sponsor. 18 are open to participants now and 29 have results posted.

Early Phase 1 4Phase 1 16Phase 2 24Phase 3 9Phase 4 4No phase 36(a study in two phases counts in both)

Studies

Open to participants first, then studies with results posted, then the rest; newest registration first within each.

• Semaglutide Dose Effects on Metabolic and Stress Hormone, Craving and Alcohol Use OutcomesNot yet recruitingNCT07772960Phase 1
• Effects of Nimodipine on Alcohol DrinkingNot yet recruitingNCT07681869Phase 2
• A Digital Pill System to Measure and Support Acamprosate Adherence in Individuals With Alcohol Associated Liver DiseaseNot yet recruitingNCT07553377Not applicable
• Trial Phase: Syndemic Adapted Medly UgandaNot yet recruitingNCT07525271Not applicable
• Implementation Facilitation Pilot for Alcohol Use Disorder (AUD) in Alcohol-associated Liver Disease (ALD)RecruitingNCT07525258Not applicable
• Imaging Phosphodiesterase 4B (PDE4B) in People With Psychiatric Disorders With Positron Emission Tomography (PET) and the Radiotracer [18F]PF974RecruitingNCT07488819
• LDART for Alcohol Use DisorderEnrolling by invitationNCT07221383Not applicable
• Off-Label Medications for Alcohol Use Disorder Among Patients With HIV: Pilot Study 3 SemaglutideRecruitingNCT07040592Phase 2
• Phase 2 Study of Apremilast in Women and Men With Alcohol Use DisorderRecruitingNCT07029529Phase 2
• Pilot Study: Effects of Nimodipine on Alcohol DrinkingNot yet recruitingNCT06900998Phase 2
• Drinking, Acetate, and StressRecruitingNCT06584448Not applicable
• Developing a Novel Human Laboratory Paradigm for AUD Medication ScreeningRecruitingNCT06489782Not applicable
• Imaging Traumatic Stress and Alcohol Use Disorder With [18F]BavarostatRecruitingNCT06371404
• Influence of Mavoglurant on Alcohol Craving and Drinking in Heavy DrinkersRecruitingNCT06136195Phase 1
• The Potential Therapeutic Effects of Psychedelic, N, N-dimethyltryptamine (DMT), on Alcohol Use Disorder (AUD)RecruitingNCT06070649Phase 1
• Investigating the Mu:Kappa Opioid Receptor Imbalance in Alcohol Use DisorderRecruitingNCT05957159Early Phase 1
• Emergency Department-Initiated Medications for Alcohol Use DisorderRecruitingNCT05827159Phase 3
• Pregnenolone for the Treatment of Alcohol Use DisorderRecruitingNCT05781009Phase 2
• Effect of Endotoxin on Alcohol ConsumptionCompletedNCT04527185Phase 2Results posted
• Preliminary Effectiveness of Remotely Monitored Blood Alcohol Concentration Device as Treatment ModalityCompletedNCT04380116Not applicableResults posted
• Neurobiological Responses in Alcoholism and Early TraumaCompletedNCT04128228Not applicableResults posted
• Effect of Allopregnanolone on Stress-induced CravingCompletedNCT04015869Phase 1Results posted
• The Role of Neuroactive Steroids in Stress, Alcohol Craving and Alcohol Use in Alcohol Use DisordersCompletedNCT03872128Phase 1Results posted
• CBT4CBT With Spanish Alcohol UsersCompletedNCT03474588Not applicableResults posted
• Efficacy and Mechanisms of CBT4CBT for Alcohol Use DisordersCompletedNCT02742246Not applicableResults posted
• Progesterone Effect on Individuals Diagnoses With AD and PTSD.CompletedNCT02187224Phase 2/3Results posted
• Zonisamide in Addition to E-CPT-C for Veterans With PTSD and Comorbid Alcohol DependenceCompletedNCT01847469Phase 2Results posted
• Functional Neuroimaging of Alcoholism Vulnerability (PIT)CompletedNCT01585168Phase 2Results posted
• Zonisamide for Heavy Drinkers With Bipolar DisorderTerminatedNCT01566370Phase 2Results posted
• Varenicline Treatment of Alcohol Dependence in SmokersCompletedNCT01553136Phase 2Results posted
• Screening to Augment Referral to Treatment- Project STARTCompletedNCT01539525Not applicableResults posted
• Alcohol Pharmacotherapy for HIV+ PrisonersCompletedNCT01077310Not applicableResults posted
• Effect of Varenicline on Fixed-Dose Alcohol Administration in Participants With Alcohol Use DisordersCompletedNCT01000987Phase 2Results posted
• Prazosin for Treatment of Patients With Alcohol Dependence (AD) and Post Traumatic Stress Disorder (PTSD).CompletedNCT00744055Phase 3Results posted
• Glycine and Oral D-Cycloserine in Alcoholic Patients and Healthy SubjectsCompletedNCT00635102Not applicableResults posted
• Intravenous Alcohol Administration Using BrAc Method in Healthy Subjects With and Without a Family History of AlcoholismCompletedNCT00612352Not applicableResults posted
• GABA Mechanisms Underlying the Vulnerability to Alcohol DependenceCompletedNCT00611767Not applicableResults posted
• Ketamine/Placebo Family History Positive StudyCompletedNCT00588952Not applicableResults posted
• Prazosin to Reduce Stress-Induced Alcohol/Drug Craving and RelapseCompletedNCT00585780Phase 1/2Results posted
• Naltrexone for Heavy Drinking in Young AdultsCompletedNCT00568958Phase 4Results posted
• Mecamylamine for the Treatment of Patients With Depression and Alcohol DependenceCompletedNCT00563797Phase 3Results posted
• Treatment With Acamprosate in Patients With Schizophrenia and Comorbid AlcoholismCompletedNCT00463346Phase 3Results posted
• Treatment With Mecamylamine in Smoking and Non-smoking Alcohol Dependent PatientsCompletedNCT00342563Phase 2Results posted
• Naltrexone & SSRI in Alcoholics With Depression/PTSDCompletedNCT00338962Phase 3Results posted
• Facilitation of NMDA Receptor Function in Patients With Schizophrenia and Co-morbid AlcoholismCompletedNCT00338598Phase 2Results posted
• Therapeutic Substance Abuse Treatment in Pregnancy - 1CompletedNCT00227903Phase 2Results posted
• Combination Nicotine Replacement for Alcoholic SmokersCompletedNCT00064844Phase 4Results posted
• Semaglutide (SEMA) for Alcohol Use Disorder (AUD) After Metabolic and Bariatric Surgery (MBS)Active, not recruitingNCT07223983Phase 1
• rTMS as Add on Treatment for Substance Use DisordersCompletedNCT06963476Not applicable
• Computer Game, Qualitative, and MEG/EEG Assessment of Serotonergic PsychedelicsTerminatedNCT06624137
• Apremilast for Alcohol Use Disorder Treatment in Women and MenActive, not recruitingNCT06324435Phase 1
• Off-Label Medications for Alcohol Use Disorder Among Patients With HIV: Pilot Study 2Active, not recruitingNCT06006143Phase 2
• Off-Label Medications for Alcohol Use Disorder Among Patients With HIV: Pilot Study 1CompletedNCT06004830Phase 2
• Metabolism in the Human Brain Following Consumption of a Keto-ester in Alcohol Use Disorder (AUD) With Proton Magnetic Resonance Spectroscopic Imaging (MRSI)CompletedNCT05937893Not applicable
• Self Management and Recovery Training (SMART) Recovery StudyWithdrawnNCT05756114Not applicable
• Promoting Alcohol Treatment Engagement Post-hospitalizationCompletedNCT05338151Not applicable
• Developing e-Covery, an App-based Intervention to Support Individuals With Co-occurring Problem Alcohol and Opioid UseCompletedNCT05325788Not applicable
• Utility of Brexanolone to Target Stress-induced Alcohol Use Among Men and Women With Posttraumatic Stress DisorderActive, not recruitingNCT05223829Phase 1
• Novel Real-world Methods in Social Drinkers and AUDCompletedNCT05155176
• FAAH Availability in Psychiatric Disorders: A PET StudyTerminatedNCT04404712Early Phase 1
• Promoting Medications for Alcohol Use Disorder on the General Medicine ServiceTerminatedNCT04287790
• Metabotropic Glutamate Receptor-5 (mGlur5) Effects on Reward-Related fMRI-BOLD Activation in FHP and FHNCompletedNCT03341715Early Phase 1
• Neuroendocrine Response to Oral Alcohol AdministrationCompletedNCT03165942Phase 1
• Fish Oil vs. Placebo on Subjective Effects of AlcoholCompletedNCT03010917Phase 1
• Multimodal Neuroimaging of Stress and Reward Cues to Assess Alcoholism Risk and RelapseCompletedNCT02616094Not applicable
• The Tolerability and Effects of AZD0530 in Individuals With or Without a Family History of AlcoholismCompletedNCT02262026Phase 1
• Automated Bilingual Computerized Alcohol Screening and Intervention in Latinos (AB-CASI)CompletedNCT02247388Not applicable
• Varenicline + Prazosin for Heavy Drinking SmokersCompletedNCT02193256Early Phase 1
• Chronic Alcohol, Stress Inflammatory Response and Relapse RiskCompletedNCT02193204Not applicable
• Minocycline's Effects on Alcohol Responses in HumansCompletedNCT02187211Phase 1
• Imaging of Cannabinoid 1 Receptors Using [11C]OMAR and PETCompletedNCT01719497
• Norepinephrine Transporter Imaging in Addiction DisordersWithdrawnNCT01719458
• Web-based CBT4CBT for AlcoholCompletedNCT01615497Not applicable
• FMRI of Stress and Addictive DisordersCompletedNCT01558973
• Ketamine for Depression and Alcohol DependenceCompletedNCT01551329Phase 1
• Integrated Stepped Care for Unhealthy Alcohol Use in HIVCompletedNCT01410123Not applicable
• Alcohol Counseling for Telephone Quitline CallersCompletedNCT01120080Phase 1/2
• Chronic Alcohol and Brain Stress Circuit ResponseCompletedNCT01031264
• Stress Reactivity in Veterans Receiving Pharmacological Treatment for PTSD and Alcohol DependenceCompletedNCT00923923Not applicable
• Modification of Cognitive Processing Therapy (CPT-C) for PTSD and Alcohol DependenceCompletedNCT00639288Phase 2/3
• Cannabinoid Receptor Function & AlcoholismCompletedNCT00624715Phase 1
• Couples-based Behavioral Psychotherapy for Male Patients With Posttraumatic Stress Disorder and Alcohol DependenceWithdrawnNCT00622921Phase 2/3
• The Use of Anticonvulsants for Treatment of Patients With Alcohol Dependence and Post Traumatic Stress DisorderWithdrawnNCT00571246Phase 3
• Acamprosate Treatment: Mechanisms of ActionCompletedNCT00004552Phase 2
• Smoking Cessation in Alcoholism TreatmentCompletedNCT00000454Phase 4
• Drug Therapy for Alcohol Dependence in Alaska Natives (Naltrexone/Sertraline)CompletedNCT00000451Phase 2
• Naltrexone Treatment for Alcoholic WomenCompletedNCT00000448Phase 4
• Disulfiram for Cocaine-Alcohol Abuse - 3CompletedNCT00000278Phase 2