University of Virginia: Polycystic Ovary Syndrome trials

The registry lists 25 Polycystic Ovary Syndrome studies with University of Virginia as lead sponsor. 11 are open to participants now and 3 have results posted.

Early Phase 1 12Phase 1 2No phase 11(a study in two phases counts in both)

Studies

Open to participants first, then studies with results posted, then the rest; newest registration first within each.

• Does Spironolactone Normalize Sleep-wake Luteinizing Hormone Pulse Frequency in Pubertal Girls With Hyperandrogenism?RecruitingNCT04723862Early Phase 1
• Androgen Blockade and Progesterone Augmentation of Gonadotropin SecretionRecruitingNCT04597099Early Phase 1
• Does Treatment of Androgen Excess Using Spironolactone Improve Ovulatory Rates in Girls With Androgen Excess?RecruitingNCT04075149Early Phase 1
• Relative Contributions of Predictors of Hyperandrogenism in Older vs. Young Women With PCOSRecruitingNCT03905603Early Phase 1
• Study to Assess Potential Impairments in Estradiol Augmentation of Gonadotropin Secretion in Polycystic Ovary SyndromeRecruitingNCT03401047Early Phase 1
• Hyperandrogenemia and Altered Day-night LH Pulse PatternsRecruitingNCT03068910Early Phase 1
• Go Girls! Fitness Support Group Intervention Effectiveness StudyRecruitingNCT02117063Not applicable
• Suppression of Daytime and Nighttime Luteinizing Hormone Frequency by ProgesteroneRecruitingNCT01428089Phase 1
• Effect of Spironolactone on Adrenal or Ovarian Androgen Production in Overweight Pubertal Girls With Androgen ExcessRecruitingNCT01422759Not applicable
• Effect of Metformin on Adrenal or Ovarian Androgen Production in Overweight Pubertal Girls With Androgen ExcessRecruitingNCT01422746Early Phase 1
• Acute Progesterone Suppression of Wake vs. Sleep Luteinizing Hormone Pulse Frequency in Pubertal Girls With and Without HyperandrogenismRecruitingNCT00929006Early Phase 1
• Assessment of Sensitivity of the Hypothalamic GnRH Pulse Generator to Estradiol and Progesterone InhibitionTerminatedNCT01428245Not applicableResults posted
• Effects of Androgen Blockade on Sensitivity of the GnRH Pulse Generator to Suppression by Estradiol and ProgesteroneTerminatedNCT01428193Not applicableResults posted
• Effect of Metformin on Sensitivity of the GnRH Pulse Generator to Suppression by Estradiol and ProgesteroneCompletedNCT01427595Not applicableResults posted
• Relative Desirability of Metformin vs. Birth Control Pill in Treating PCOS in Women of Later Reproductive AgeWithdrawnNCT03905941Early Phase 1
• Urinary DENND1A.V2 as a Predictor of Pubertal HyperandrogenemiaSuspendedNCT02611128
• Assessment of the Sensitivity of the Hypothalamic GnRH Pulse Generator to Estradiol and Progesterone InhibitionActive, not recruitingNCT01425541Not applicable
• Effect of Longer-term Adrenal Suppression Using Low Dose Hydrocortisone on Androgen OverproductionWithdrawnNCT01422733Early Phase 1
• Effect of Short Term Adrenal Suppression on Androgen Overproduction in Overweight Girls With Androgen ExcessWithdrawnNCT01422707Early Phase 1
• Effect of Short Term Ovarian Suppression on Androgen Overproduction in Overweight Girls With Androgen ExcessWithdrawnNCT01422096Early Phase 1
• Ovarian Contribution to Androgen Production in Adolescent GirlsActive, not recruitingNCT01421810Not applicable
• Evaluation of Adrenal Androgens in Normal and Obese Girls After Suppression and StimulationActive, not recruitingNCT01421797Not applicable
• Effect of High Testosterone on Sleep-associated Slowing of Follicular Luteinizing Hormone (LH) Frequency in Polycystic Ovary SyndromeStatus unknownNCT00930228Phase 1
• Etiological Factors of Obesity-Associated Hyperandrogenemia in Peripubertal GirlsStatus unknownNCT00928759
• Acupuncture for Polycystic Ovarian SyndromeStatus unknownNCT00602940Not applicable