University of Virginia: Hyperandrogenism trials

The registry lists 16 Hyperandrogenism studies with University of Virginia as lead sponsor. 9 are open to participants now and 2 have results posted.

Early Phase 1 8Phase 1 1No phase 7(a study in two phases counts in both)

Studies

Open to participants first, then studies with results posted, then the rest; newest registration first within each.

• Does Spironolactone Normalize Sleep-wake Luteinizing Hormone Pulse Frequency in Pubertal Girls With Hyperandrogenism?RecruitingNCT04723862Early Phase 1
• Does Treatment of Androgen Excess Using Spironolactone Improve Ovulatory Rates in Girls With Androgen Excess?RecruitingNCT04075149Early Phase 1
• Relative Contributions of Predictors of Hyperandrogenism in Older vs. Young Women With PCOSRecruitingNCT03905603Early Phase 1
• Hyperandrogenemia and Altered Day-night LH Pulse PatternsRecruitingNCT03068910Early Phase 1
• Assessment of Day-night Secretion of Progesterone and LH Across PubertyRecruitingNCT02155933
• Suppression of Daytime and Nighttime Luteinizing Hormone Frequency by ProgesteroneRecruitingNCT01428089Phase 1
• Effect of Spironolactone on Adrenal or Ovarian Androgen Production in Overweight Pubertal Girls With Androgen ExcessRecruitingNCT01422759Not applicable
• Effect of Metformin on Adrenal or Ovarian Androgen Production in Overweight Pubertal Girls With Androgen ExcessRecruitingNCT01422746Early Phase 1
• Acute Progesterone Suppression of Wake vs. Sleep Luteinizing Hormone Pulse Frequency in Pubertal Girls With and Without HyperandrogenismRecruitingNCT00929006Early Phase 1
• Effects of Androgen Blockade on Sensitivity of the GnRH Pulse Generator to Suppression by Estradiol and ProgesteroneTerminatedNCT01428193Not applicableResults posted
• Effect of Metformin on Sensitivity of the GnRH Pulse Generator to Suppression by Estradiol and ProgesteroneCompletedNCT01427595Not applicableResults posted
• Urinary DENND1A.V2 as a Predictor of Pubertal HyperandrogenemiaSuspendedNCT02611128
• Effect of Short Term Adrenal Suppression on Androgen Overproduction in Overweight Girls With Androgen ExcessWithdrawnNCT01422707Early Phase 1
• Effect of Short Term Ovarian Suppression on Androgen Overproduction in Overweight Girls With Androgen ExcessWithdrawnNCT01422096Early Phase 1
• Ovarian Contribution to Androgen Production in Adolescent GirlsActive, not recruitingNCT01421810Not applicable
• Sleep-wake Changes of Luteinizing Hormone Frequency in Pubertal Girls With and Without High TestosteroneStatus unknownNCT00930007