University Health Network, Toronto: Prostatic Neoplasms trials

The registry lists 91 Prostatic Neoplasms studies with University Health Network, Toronto as lead sponsor. 17 are open to participants now and 1 have results posted.

Phase 1 8Phase 2 30Phase 3 3Phase 4 2No phase 52(a study in two phases counts in both)

Studies

Open to participants first, then studies with results posted, then the rest; newest registration first within each.

• 68Ga-PSMA-11 PET/MRI for Selecting Men With Prostate Cancer for Focal TherapyNot yet recruitingNCT07747493Not applicable
• Clinical Trial to Observe the Effects of Tamoxifen on Testosterone Recovery in Medically Castrated Prostate Cancer PatientsRecruitingNCT07535905Phase 2
• Molecular Imaging Informed Radiation Dose Escalation to Sites of Recurrent Disease and De-escalation to Uninvolved Areas in Salvage Radiotherapy Using SBRT for Prostate Cancer to Reduce Treatment ToxicityNot yet recruitingNCT07515651Phase 2
• Micro-ultrasound-Guided Focal Laser Ablation for Intermediate-Risk Prostate Cancer: Safety & EffectivenessRecruitingNCT07339943Not applicable
• Canada-wide Implementation of a Virtual Sexual Health and Rehabilitation eClinic (SHAReClinic) for Prostate Cancer Patients and Their PartnersRecruitingNCT06877598
• Salvage MR-guided High-Dose-Rate Brachytherapy for Prostate Bed Recurrence After Radiotherapy in the PSMA PET Scan EraRecruitingNCT06508567Not applicable
• A Pan-Canadian, Investigator Initiated Clinical Trial With Focal IRE Directed to Intermediate-Risk Prostate CancerRecruitingNCT06451445Not applicable
• Remote Monitoring of Patient Reported Outcomes to Improve the Efficacy of the Acute Phase Radiotherapy Review ProcessRecruitingNCT06274892Not applicable
• TOward a comPrehensive Supportive Care Intervention for Older Men With Metastatic Prostate CancerRecruitingNCT05582772Not applicable
• Duration of Androgen Receptor Pathway Inhibitor and ADT With Metastasis Directed Therapy in Oligometastatic Cancer of the Prostate (DIRECT)RecruitingNCT05404139Phase 2
• Marathon of Hope Cancer Centres Network Study for Ontario (MOHCCN-O)RecruitingNCT05403177
• Molecular Imaging Informed Radiation Dose Escalation to Sites of Recurrent Disease and De-escalation to Uninvolved Areas in Salvage Radiotherapy for Prostate CancerRecruitingNCT05328505Not applicable
• Moderate Hypofractionated Boost to the Prostate With Pelvic RT in High Risk Prostate CancerRecruitingNCT05313815Not applicable
• Evaluating the Effectiveness of the Nurse Ned ClinicRecruitingNCT05033301Not applicable
• Study of Radiation Therapy in Combination With Darolutamide + Degarelix in Intermediate Risk Prostate CancerNot yet recruitingNCT04176081Phase 2
• MRI Guided Focal Laser Ablation of Prostate CancerRecruitingNCT03650595Not applicable
• High-Dose-Rate BrachytherapyRecruitingNCT00913939Not applicable
• A Safety and Feasibility Study of Mitotane in Prostate CancerCompletedNCT02057237Phase 1Results posted
• MR-guided Tumour BoostActive, not recruitingNCT05364229Not applicable
• A Web-based Peer Navigation Program for Men With Prostate CancerCompletedNCT05041504Not applicable
• Timing of Post-prostatectomy PSMA ImagingCompletedNCT05008900Phase 2
• Toward a Comprehensive Supportive Care Intervention for Older or Frail Men With mCRPCCompletedNCT04193657
• PSMA PET Registry (18F-DCFPyL)CompletedNCT03535831Not applicable
• Radium-223 Combined With Dexamethasone as First-line Therapy in Patients With M+CRPCActive, not recruitingNCT03432949Phase 4
• Sexual Health and Rehabilitation eClinic (SHAReClinic)Status unknownNCT03396848Not applicable
• Preference-Based Exercise RCT for Men With PC on ADTCompletedNCT03335631Not applicable
• Prostate Cancer Subclinical Metastatic Ablative MR-guided RadiotherapyCompletedNCT03160794Not applicable
• Detection of Clinically Significant Prostate Cancer With 18F-DCFPyL PET/MRCompletedNCT03149861Not applicable
• PC 360 SurvivorshipCompletedNCT03017456Not applicable
• HDR Focal: Feasibility StudyActive, not recruitingNCT02918253Not applicable
• ADT Exercise Trial and Economic AnalysisCompletedNCT02834416Phase 3
• Preoperative Brimonidine on IOP of Patients Undergoing RALPCompletedNCT02818816Phase 4
• Detection and Localization of Carcinoma Using High Resolution Transrectal Imaging - Proof of Concept StudyCompletedNCT02786459Not applicable
• A Bio-psychosocial Sexual Health Intervention for Prostate Cancer Survivors and Partners: a Feasibility StudyCompletedNCT02640131Not applicable
• Anti-Androgens and Cabazitaxel in Defining Complete Response in Prostatectomy (ACDC Trial)CompletedNCT02543255Phase 2
• Towards Optimal Prescription of Chemotherapy in Prostate CancerCompletedNCT02512185
• LIpitor and biGuanide to Androgen Delay TrialWithdrawnNCT02497638Phase 2
• Biomarkers of Androgen Response and Resistance In Evolution During a Rising PSACompletedNCT02429193Phase 2
• Prostate Hypoxia - TICActive, not recruitingNCT02095249Not applicable
• An Exercise Trial and Economic Analysis in Men With Prostate CancerCompletedNCT02046837Phase 2
• Strategies to Improve Bone Health in Men on ADTCompletedNCT02043236Not applicable
• Prostatectomy Adaptive Radiation Therapy (ART)CompletedNCT02034955Not applicable
• 18F-FCH (Fluorocholine)-PET/MR in Staging of High-Risk Prostate CancerCompletedNCT01993160Not applicable
• Novel Window of Opportunity Trial to Evaluate the Impact of Statins to Oppose Prostate CancerCompletedNCT01992042Phase 2
• Periperal Blood Lymphocytes During Prostate RTWithdrawnNCT01899391
• Prostate Delineation: High Quality Volume CTCompletedNCT01878773Not applicable
• Identifying Prostate Brachytherapy Seeds Using MRICompletedNCT01878058Not applicable
• The Metformin Active Surveillance Trial (MAST) StudyActive, not recruitingNCT01864096Phase 3
• A Correlative Study of Biomarkers of Resistance in Patients With Castrate Resistant Prostate Cancer Treated With AbirateroneCompletedNCT01857908
• Tumor TARGET Prostate CancerCompletedNCT01802242Not applicable
• Pantoprazole and Docetaxel for Men With Metastatic Castration-Resistant Prostate CancerCompletedNCT01748500Phase 2
• Prostate Cancer Active Surveillance Metformin TrialWithdrawnNCT01733836Phase 2
• Degarelix Neo-Adjuvant Radical Prostatectomy TrialCompletedNCT01674270Phase 2
• Prostate Hypoxia FAZACompletedNCT01567800Not applicable
• Combination Statin, Acetylsalicylic Acid and Dutasteride Use in Prostate CancerCompletedNCT01428869
• MRI Targeted Focal Laser Thermal Therapy of Prostate CancerCompletedNCT01094665Not applicable
• Duration of Suppression of Bone Turnover Following Treatment With Zoledronic Acid in Men With Metastatic CRPCCompletedNCT01062503
• An Alternative to A Fixed Schedule In Management Of Prostate CancerCompletedNCT01056562
• Trans-Rectal Ultrasound-Guided (TRUS) Adverse EventsCompletedNCT00923416
• Advanced Imaging for Radiotherapy Treatment Planning and Guidance for Low-Intermediate Risk Prostate Cancer (Margin)Active, not recruitingNCT00890006Not applicable
• A Study of Pre-operative Metformin in Prostate CancerTerminatedNCT00881725Phase 2
• Study of Antioxidants on Prostate Tumors in Men Undergoing Radical Prostatectomy for Prostate CancerCompletedNCT00844792Phase 2
• MRI Targeted Focal Laser Thermal Therapy of Prostate Cancer Followed by Radical ProstatectomyCompletedNCT00805883Phase 1
• Salvage Prostatectomy After RadiotherapyCompletedNCT00791115Not applicable
• Fiducial Localization and Individualized Radiotherapy -Prostate CancerCompletedNCT00789607Not applicable
• MRI-Guided Biopsy of Recurrent Prostate Cancer After RadiotherapyCompletedNCT00775866Not applicable
• Study of Antioxidants on MRI Detectable Early Stage Prostate Cancer Among Men on Active SurveillanceCompletedNCT00744549Phase 2
• Efficacy Study of Methylphenidate Hydrochloride to Reduce Fatigue in Prostate Cancer Patients Receiving Hormone TherapyTerminatedNCT00593853Phase 2
• The Effect of Radiation on Semen Quality and Fertility in Men With Prostate CancerCompletedNCT00496249
• A Phase II Study of Ara-C (Cytarabine) in Men With Androgen Independent Prostate CancerCompletedNCT00480090Phase 2
• MRI Targeted Focal Laser Thermal Therapy of Biopsy Confirmed Prostate CancerCompletedNCT00448695Phase 1
• Sexual Dysfunction and Adaptation in Couples Affected by Prostate Cancer SurgeryCompletedNCT00335634
• CT/MRI Co-registration Prostate CancerCompletedNCT00252460
• Preop Conformal Radiotherapy - ProstateCompletedNCT00252447Phase 1/2
• Erectile Dysfunction/Prostate/RT/AndrogenCompletedNCT00242138Phase 2
• Defining the Extent and Grade of Prostate Cancer Using Dynamic Contrast Enhanced Diffusion Weighted and BOLD MRICompletedNCT00242112Not applicable
• The Potential Use of BOLD MRI as a Noninvasive Measure of Tumor Hypoxia in Prostate CancerCompletedNCT00242073Not applicable
• Functional and Morphologic MRI in the Detection of Prostate Cancer in Patients With Prior Negative BiopsyCompletedNCT00242060Not applicable
• External Beam Radiation Therapy - Target VolumeCompletedNCT00230438Phase 2
• Role of Magnetic Resonance Imaging (MRI) Perfusion to Detect Disease in Prostate CarcinomaCompletedNCT00230386Phase 1/2
• Xray Volume Imaging (Cone Beam CT) - Prostate CancerCompletedNCT00188799Phase 2
• Cone Beam CT for Daily Image Guidance - Prostate CancerCompletedNCT00188786Phase 2
• Effect of Casodex on Tumour Hypoxia - Prostate CancerCompletedNCT00188708Not applicable
• Combidex USPIO - Ultra-small Superparamagnetic Iron OxideCompletedNCT00188695Phase 1/2
• Intensity Modulated Radiation Therapy - Prostate CancerCompletedNCT00188513Phase 1/2
• Transrectal Tumour Oxygen - US ArmyCompletedNCT00160979Phase 2
• Endorectal Coil Magnetic Resonance Images (ERC-MRI)CompletedNCT00160953Phase 2
• Mobicox: Study of Meloxicam to Reduce Prostate Swelling in Permanent Seed Prostate BrachytherapyCompletedNCT00152919Phase 3
• Normal Prostate: Oxygenation of the Prostate Gland in Men Undergoing Prostate BiopsyCompletedNCT00152789Phase 2
• GTI-2040, Docetaxel, and Prednisone in Treating Patients With Prostate CancerCompletedNCT00087165Phase 2
• EF5 Prior to Surgery or Biopsy in Patients With Breast, Prostate, or Cervical Cancer or High Grade Soft Tissue SarcomaTerminatedNCT00004261Phase 1