The Hospital for Sick Children: Cystic Fibrosis trials

The registry lists 18 Cystic Fibrosis studies with The Hospital for Sick Children as lead sponsor. 3 are open to participants now and 1 have results posted.

Phase 1 1Phase 2 5Phase 3 4Phase 4 1No phase 7(a study in two phases counts in both)

Studies

Open to participants first, then studies with results posted, then the rest; newest registration first within each.

• MRI Assessment of Lung Airways in Cystic Fibrosis: Evaluate MRI's Ability to Detect Changes in Airway Structure .Not yet recruitingNCT07454681
• Xenon-129 and Inert Fluorinated Gas Lung MRI: Study of Healthy Volunteers and Participants With Pulmonary DiseaseRecruitingNCT02740868Phase 2
• Measures of Respiratory Health (MRH)RecruitingNCT02657837
• Tolerability of Hypertonic Saline in Infants With Cystic FibrosisCompletedNCT00753987Phase 1Results posted
• Intestinal Inflammation in CF PatientsActive, not recruitingNCT04392544
• CFTR Related Pancreatitis StudyWithdrawnNCT04274413Not applicable
• Prednisone in Cystic Fibrosis Pulmonary ExacerbationsCompletedNCT03070522Phase 3
• Hyperpolarized Xenon MRI in Cystic Fibrosis Pulmonary ExacerbationsCompletedNCT02606487
• A Randomized-Controlled Trial of Inhaled Hypertonic Saline (7%) to Evaluate the Lung Clearance IndexCompletedNCT02276898Phase 2
• Dynamic Contrast Enhanced Magnetic Resonance Perfusion Imaging in Congenital Heart Disease and Lung DiseaseCompletedNCT01192360Phase 3
• Inflammatory and Microbiologic Markers in Sputum: Comparing Cystic Fibrosis With Primary Ciliary DyskinesiaCompletedNCT01155115Not applicable
• Use of a Biofilm Antimicrobial Susceptibility Assay to Guide Antibiotic TherapyCompletedNCT00786513Phase 2
• Utility of Induced Sputum Using Hypertonic Saline to Evaluate Infection and Inflammation in Cystic FibrosisCompletedNCT00721071Phase 2
• Modulation by Sex Hormones of Inflammation and Susceptibility to Pseudomonas Aeruginosa in Cystic Fibrosis AirwaysCompletedNCT00700050
• 18FDG-PET Imaging to Detect Changes in Airways Inflammation in Cystic Fibrosis PatientsCompletedNCT00684346Phase 3
• The Effect of Hypertonic Saline on the Lung Clearance Index in Patients With Cystic FibrosisCompletedNCT00635141Phase 3
• The Effect of rhDNase on Ventilation Inhomogeneity in Patients With Cystic FibrosisCompletedNCT00557089Phase 4
• The Short Term Safety and Efficacy of Inhaled L-arginine in Patients With Cystic FibrosisCompletedNCT00405665Phase 2