Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins: Colorectal Neoplasms trials

The registry lists 15 Colorectal Neoplasms studies with Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins as lead sponsor. 3 are open to participants now and 6 have results posted.

Phase 1 7Phase 2 7No phase 2(a study in two phases counts in both)

Studies

Open to participants first, then studies with results posted, then the rest; newest registration first within each.

• Capecitabine/Oxaliplatin Chemotherapy and Cemiplimab With or Without Fianlimab or REGN7075 in Locally Advanced Rectal CancerRecruitingNCT07281768Phase 2
• KRAS-Targeted Vaccine Combined With Balstilimab and Botensilimab for Patients With Stage IV MMR-p Colorectal Cancer and Pancreatic Ductal CancerRecruitingNCT06411691Phase 1
• Cemiplimab With or Without Fianlimab to Treat Older Patients With Localized or Locally Advanced MSI-H Colorectal CancerRecruitingNCT06205836Phase 2
• TheraSphere® For Treatment of Metastases in LiverCompletedNCT04517643Not applicableResults posted
• Study of Nivolumab and Relatlimab in Patients With Microsatellite Stable (MSS) Advanced Colorectal CancerCompletedNCT03642067Phase 2Results posted
• Study of GVAX (With CY) and Pembrolizumab in MMR-p Advanced Colorectal CancerCompletedNCT02981524Phase 2Results posted
• Phase I/II Study of SGI-110 With Irinotecan Versus Regorafenib or TAS-102 in Metastatic Colorectal CancerCompletedNCT01896856Phase 1/2Results posted
• Study of MK-3475 in Patients With Microsatellite Unstable (MSI) Tumors (Cohorts A, B and C)CompletedNCT01876511Phase 2Results posted
• Everolimus in Treating Patients With Advanced or Metastatic Colorectal Cancer That Did Not Respond to Previous TherapyTerminatedNCT00390364Phase 2Results posted
• Neoantigen-Targeted Vaccine Combined With Anti-PD-1 Antibody for Patients With Stage IV MMR-p Colon and Pancreatic Ductal CancerWithdrawnNCT04799431Phase 1
• Pooled Mutant KRAS-Targeted Long Peptide Vaccine Combined With Nivolumab and Ipilimumab for Patients With Resected Mismatch Repair Protein (MMR-p) Colorectal and Pancreatic CancerActive, not recruitingNCT04117087Phase 1
• A Study of Enhancing Response to MK-3475 in Advanced Colorectal CancerCompletedNCT02512172Phase 1
• SGI-110 in Combination With an Allogeneic Colon Cancer Cell Vaccine (GVAX) and Cyclophosphamide (CY) in Metastatic Colorectal Cancer (mCRC)CompletedNCT01966289Phase 1
• Study of Colon GVAX and Cyclophosphamide in Patients With Metastatic Colorectal CancerCompletedNCT00656123Phase 1
• Pattern of Cell Death Following Neoadjuvant Therapy for Metastatic Colon CancerCompletedNCT00414492