Novo Nordisk A/S: Diabetes Mellitus, Type 2 trials

The registry lists 633 Diabetes Mellitus, Type 2 studies with Novo Nordisk A/S as lead sponsor. 22 are open to participants now and 175 have results posted.

Phase 1 122Phase 2 37Phase 3 184Phase 4 75No phase 215(a study in two phases counts in both)

Studies

Page 2 of 7. Open to participants first, then studies with results posted, then the rest; newest registration first within each.

• A Trial Comparing Sequential Addition of Insulin Aspart Versus Further Dose Increase With Insulin Degludec/Liraglutide in Subjects With Type 2 Diabetes Mellitus, Previously Treated With Insulin Degludec/Liraglutide and Metformin and in Need of Further IntensificationCompletedNCT02100475Phase 3Results posted
• Efficacy and Safety of Semaglutide Once-weekly Versus Placebo in Drug-naïve Subjects With Type 2 DiabetesCompletedNCT02054897Phase 3Results posted
• A Trial Comparing the Safety and Efficacy of Insulin Degludec and Insulin Glargine, With or Without OADs in Subjects With Type 2 DiabetesCompletedNCT02030600Phase 3Results posted
• The Efficacy and Safety of Liraglutide Compared to Sitagliptin, Both in Combination With Metformin in Chinese Subjects With Type 2 DiabetesCompletedNCT02008682Phase 4Results posted
• Efficacy and Safety of Liraglutide Versus Lixisenatide as add-on to Metformin in Subjects With Type 2 DiabetesCompletedNCT01973231Phase 4Results posted
• A Trial Comparing Cardiovascular Safety of Insulin Degludec Versus Insulin Glargine in Subjects With Type 2 Diabetes at High Risk of Cardiovascular EventsCompletedNCT01959529Phase 3Results posted
• A Trial Comparing the Efficacy and Safety of Insulin Degludec/Liraglutide Versus Insulin Glargine in Subjects With Type 2 Diabetes MellitusCompletedNCT01952145Phase 3Results posted
• Efficacy and Safety of Semaglutide Once-weekly Versus Sitagliptin Once-daily as add-on to Metformin and/or TZD in Subjects With Type 2 DiabetesCompletedNCT01930188Phase 3Results posted
• Multiple Dose Trial Examining Dose Range, Escalation and Efficacy of Oral Semaglutide in Subjects With Type 2 DiabetesCompletedNCT01923181Phase 2Results posted
• Efficacy and Safety of Liraglutide Versus Sulphonylurea Both in Combination With Metformin During Ramadan in Subjects With Type 2 DiabetesCompletedNCT01917656Phase 4Results posted
• Efficacy and Safety of Switching From Sitagliptin to Liraglutide in Subjects With Type 2 Diabetes Not Achieving Adequate Glycaemic Control on Sitagliptin and MetforminCompletedNCT01907854Phase 4Results posted
• Investigating Efficacy and Safety of Biphasic Insulin Aspart 50 Twice Daily Versus Biphasic Human Insulin 50 Twice Daily Both in Combination With Metformin in Chinese Subjects With Type 2 Diabetes MellitusCompletedNCT01892020Phase 4Results posted
• Efficacy and Safety of Semaglutide Once-weekly Versus Exenatide ER 2.0 mg Once-weekly as add-on to 1-2 Oral Antidiabetic Drugs (OADs) in Subjects With Type 2 DiabetesCompletedNCT01885208Phase 3Results posted
• A Trial Investigating the Efficacy and Safety of Flexible vs. Fixed Dosing and Simple vs. Stepwise Titration With Once Daily (OD) Insulin Degludec in Inadequately Treated Subjects With Type 2 DiabetesCompletedNCT01880736Phase 3Results posted
• A Trial Comparing the Glycaemic Control of Levemir® Administered Once Daily According to Two Insulin Detemir Titration Algorithms After 20 Weeks in Subjects With Type 2 Diabetes Mellitus Inadequately Controlled on Metformin Treatment With or Without Other Anti-diabetic Drugs (OADs)CompletedNCT01868542Phase 4Results posted
• Efficacy and Safety of FIAsp in a Basal-bolus Regimen Versus Basal Insulin Therapy, Both in Combination With Metformin in Adult Subjects With Type 2 DiabetesCompletedNCT01850615Phase 3Results posted
• A Trial Comparing Efficacy and Safety of Insulin Degludec and Insulin Glargine in Insulin naïve Subjects With Type 2 DiabetesCompletedNCT01849289Phase 3Results posted
• Efficacy and Safety of FIAsp Compared to Insulin Aspart in Combination With Insulin Glargine and Metformin in Adults With Type 2 DiabetesCompletedNCT01819129Phase 3Results posted
• A Randomised Trial Comparing Efficacy and Safety After Intensification With Either Insulin Aspart Once Daily as add-on or Changing to Basal Bolus Treatment With Insulin Degludec and Insulin Aspart in Subjects With Type 2 Diabetes Previously Treated With Insulin Degludec/Insulin Aspart Twice DailyCompletedNCT01814137Phase 3Results posted
• Trial to Evaluate Cardiovascular and Other Long-term Outcomes With Semaglutide in Subjects With Type 2 DiabetesCompletedNCT01720446Phase 3Results posted
• A 26-week Trial Comparing Efficacy and Safety of Insulin Degludec/Insulin Aspart BID and Insulin Degludec OD Plus Insulin Aspart in Subjects With Type 2 Diabetes Mellitus Treated With Basal Insulin in Need of Treatment Intensification With Mealtime InsulinCompletedNCT01713530Phase 3Results posted
• Comparison of the Efficacy and Safety of Two Different Dose Adjustment Regimens for Insulin Degludec/Insulin Aspart in Subjects With Type 2 Diabetes Mellitus Previously Treated With Insulin GlargineCompletedNCT01680341Phase 3Results posted
• Investigation of Pain During Subcutaneous Injections With Different Injection Speed and Volume CombinationsCompletedNCT01680328Phase 1Results posted
• The Efficacy of Insulin Degludec/Liraglutide in Controlling Glycaemia in Adults With Type 2 Diabetes Inadequately Controlled on GLP-1 Receptor Agonist and OAD TherapyCompletedNCT01676116Phase 3Results posted
• The Effect of Insulin Degludec in Combination With Liraglutide and Metformin in Subjects With Type 2 Diabetes Qualifying for Treatment IntensificationCompletedNCT01664247Phase 3Results posted
• Efficacy and Safety of Liraglutide Versus Placebo as add-on to Existing Diabetes Medication in Subjects With Type 2 Diabetes and Moderate Renal ImpairmentCompletedNCT01620489Phase 3Results posted
• Comparison of Subject-driven Titration of Biphasic Insulin Aspart (BIAsp) 30 Twice Daily Versus Investigator-driven Titration of BIAsp 30 Twice Daily Both in Combination With Oral Antidiabetic Drugs in Subjects With Type 2 DiabetesCompletedNCT01618214Phase 4Results posted
• The Efficacy of Insulin Degludec/Liraglutide as add-on Therapy in Controlling Glycaemia in Adults With Type 2 Diabetes Inadequately Controlled on Sulphonylurea With or Without Metformin TherapyCompletedNCT01618162Phase 3Results posted
• The Effect of Liraglutide Versus Placebo When Added to Basal Insulin Analogues With or Without Metformin in Subjects With Type 2 DiabetesCompletedNCT01617434Phase 3Results posted
• Comparing Patient-adjusted Versus Physician-adjusted Titration of BIAsp 30 Combined With Metformin in Type 2 Diabetes PatientsCompletedNCT01589653Phase 4Results posted
• Efficacy and Safety of Liraglutide in Combination With Insulin Therapy Compared to Insulin Alone in Japanese Subjects With Type 2 DiabetesCompletedNCT01572740Phase 3Results posted
• A Trial Comparing the Efficacy, Patient-reported Outcomes and Safety of Insulin Degludec 200 U/mL vs Insulin Glargine in Subjects With Type 2 Diabetes Mellitus Requiring High-dose InsulinCompletedNCT01570751Phase 3Results posted
• Efficacy and Safety of Liraglutide in Combination With Metformin Compared to Metformin Alone, in Children and Adolescents With Type 2 DiabetesCompletedNCT01541215Phase 3Results posted
• Treatment Intensification With Biphasic Insulin Aspart 30 in Subjects With Type 2 Diabetes Inadequately Controlled on Sitagliptin and MetforminCompletedNCT01519674Phase 4Results posted
• A Trial Comparing Efficacy and Safety of Insulin Degludec/Insulin Aspart and BIAsp 30 in Insulin naïve Subjects With Type 2 DiabetesCompletedNCT01513590Phase 3Results posted
• Safety and Efficacy of Liraglutide in Combination With an OAD in Subjects With Type 2 Diabetes Insufficiently Controlled on OAD AloneCompletedNCT01512108Phase 3Results posted
• Comparing Efficacy and Safety of Insulin Detemir Plus Insulin Aspart and NPH Insulin Plus Human Soluble Insulin With or Without Metformin in Chinese Patients With Type 2 DiabetesTerminatedNCT01486966Phase 4Results posted
• Safety, Tolerability and Pharmacokinetics of Liraglutide-depot in Healthy SubjectsCompletedNCT01473953Phase 1Results posted
• Comparison of Biphasic Insulin Aspart 30 Individually Adjusted by the Subject and the Trial Physician, Both Combined With Metformin in Subjects With Type 2 DiabetesCompletedNCT01427920Phase 4Results posted
• A Trial Comparing the Efficacy and Safety of Insulin Degludec/Liraglutide and Insulin Degludec in Subjects With Type 2 DiabetesCompletedNCT01392573Phase 3Results posted
• Comparison of the Efficacy and Safety of Two Intensification Strategies in Subjects With Type 2 Diabetes Inadequately Controlled on Basal Insulin and MetforminCompletedNCT01388361Phase 3Results posted
• Efficacy and Safety of Insulin Degludec/Insulin Aspart in Insulin-naïve Subjects With Type 2 Diabetes Using Two Dosing RegimensCompletedNCT01365507Phase 3Results posted
• Comparison of Two Insulin Degludec Formulations in Subjects With Type 2 Diabetes MellitusCompletedNCT01364428Phase 3Results posted
• Dual Action of Liraglutide and Insulin Degludec in Type 2 Diabetes: A Trial Comparing the Efficacy and Safety of Insulin Degludec/Liraglutide, Insulin Degludec and Liraglutide in Subjects With Type 2 DiabetesCompletedNCT01336023Phase 3Results posted
• Comparing the Efficacy and Safety of NN1250 Once Daily When Titrated Using 2 Different Algorithms in Insulin naïve Subjects With Type 2 Diabetes MellitusCompletedNCT01326026Phase 3Results posted
• Comparison of Biphasic Insulin Aspart 30 Twice Daily With Two Different Initial Dosage Split Regimens in Subjects With Type 2 Diabetes: An Extension to Trial BIASP-3756CompletedNCT01278160Phase 4Results posted
• Comparison of NN5401 With Insulin Glargine in Insulin Naive Subjects With Type 2 DiabetesCompletedNCT01272193Phase 3Results posted
• Impact of Dietary Intervention on Weight Change in Subjects With Type 2 DiabetesCompletedNCT01232491Phase 4Results posted
• Comparison of Two Biphasic Insulin Aspart 30 Treatment Regimens in Subjects With Type 2 Diabetes Not Achieving HbA1c Treatment Targets on OADs AloneCompletedNCT01215435Phase 4Results posted
• Liraglutide Effect and Action in Diabetes: Evaluation of Cardiovascular Outcome ResultsCompletedNCT01179048Phase 3Results posted
• Efficacy and Safety of Basal-bolus Therapy, Comparing Stepwise Addition of Insulin Aspart Versus Complete Basal-bolus RegimenCompletedNCT01165684Phase 4Results posted
• Switching From Insulin Glargine to Insulin Degludec in Subjects With Type 2 Diabetes Mellitus (BEGIN™)CompletedNCT01135992Phase 3Results posted
• Comparison of the Blood Sugar Lowering Effect of Biphasic Insulin Aspart 30 and Insulin Glargine Both Combined With Metformin and Glimepiride in Chinese and Japanese Subjects With Type 2 Diabetes New to Insulin TreatmentCompletedNCT01123980Phase 4Results posted
• Comparison of NN1250 With Insulin Glargine in Subjects With Type 2 DiabetesCompletedNCT01076647Phase 3Results posted
• Comparison of NN1250 With Insulin Glargine in Subjects With Type 2 DiabetesCompletedNCT01068678Phase 3Results posted
• Comparison of NN1250 With Insulin Glargine in Subjects With Type 2 DiabetesCompletedNCT01068665Phase 3Results posted
• Effect of Different Insulin Administrations, All in Combination With Metformin, on Glycaemic Control in Subjects With Type 2 Diabetes Inadequately Controlled by Oral Anti-diabetic DrugsCompletedNCT01068652Phase 4Results posted
• A Pan Asian Trial Comparing Efficacy and Safety of NN5401 and Biphasic Insulin Aspart 30 in Type 2 DiabetesCompletedNCT01059812Phase 3Results posted
• Comparison of NN1250 Versus Insulin Glargine in Subjects With Type 2 DiabetesCompletedNCT01059799Phase 3Results posted
• Comparison of NN1250 With Sitagliptin in Subjects With Type 2 Diabetes Never Treated With InsulinCompletedNCT01046110Phase 3Results posted
• Comparison of NN5401 Versus Insulin Glargine, Both Combined With Metformin Treatment, in Subjects With Type 2 DiabetesCompletedNCT01045707Phase 3Results posted
• Comparison of NN5401 With Insulin Glargine, Both in Combination With Oral Antidiabetic Drugs, in Subjects With Type 2 DiabetesCompletedNCT01045447Phase 3Results posted
• Comparison of Repaglinide and Gliclazide in Chinese Subjects With Type 2 Diabetes Never Received Oral Antidiabetic Drug TreatmentCompletedNCT01022762Phase 4Results posted
• Comparison of NN5401 With Biphasic Insulin Aspart 30 in Type 2 DiabetesCompletedNCT01009580Phase 3Results posted
• Comparison of NN1250 With Insulin Glargine in Type 2 DiabetesCompletedNCT01006291Phase 3Results posted
• Comparison of NN1250 Versus Insulin Glargine in Subjects With Type 2 DiabetesCompletedNCT00982644Phase 3Results posted
• Comparison of NN1250 With Insulin Glargine Plus Insulin Aspart With/Without Metformin and With/Without Pioglitazone in Type 2 DiabetesCompletedNCT00972283Phase 3Results posted
• Effect of Insulin Detemir and Insulin Glargine on Blood Glucose Control in Subjects With Type 2 DiabetesCompletedNCT00909480Phase 4Results posted
• The Effect of Insulin Detemir in Combination With Liraglutide and Metformin Compared to Liraglutide and Metformin in Subjects With Type 2 DiabetesCompletedNCT00856986Phase 3Results posted
• Comparison of NN5401 Versus Biphasic Insulin Aspart 30 on a Twice Daily Regimen in Subjects With Type 2 Diabetes MellitusCompletedNCT00842361Phase 2Results posted
• Comparison of the Blood Sugar Lowering Effect Between Repaglinide Plus Metformin and Repaglinide Alone in Type 2 Diabetics Not Previously Treated With Oral Sugar-lowering DrugsCompletedNCT00819741Phase 4Results posted
• Comparing the Efficacy and Safety of Biphasic Insulin Aspart 30 and Biphasic Human Insulin 30 on Blood Sugar Control in Subjects With Type 2 DiabetesCompletedNCT00807092Phase 4Results posted
• Comparison of the Change in Fat Distribution in Overweight and Obese Subjects With Type 2 Diabetes After Insulin TreatmentCompletedNCT00795600Phase 4Results posted
• Effect of Detemir and Sitagliptin on Blood Glucose Control in Type 2 DiabetesCompletedNCT00789191Phase 3Results posted
• Efficacy, Safety and Preference Study of a Insulin Pen PDS290 vs. a Novo Nordisk Marketed Insulin Pen in DiabeticsCompletedNCT00773279Phase 3Results posted
• The Effect of Liraglutide Compared to Sitagliptin, Both in Combination With Metformin on Glycaemic Control in Subjects With Type 2 Diabetes MellitusCompletedNCT00700817Phase 3Results posted
• A Randomised Controlled Clinical Trial in Type 2 Diabetes Comparing Semaglutide to Placebo and LiraglutideCompletedNCT00696657Phase 2Results posted
• Effect of Biphasic Insulin Aspart 30 Combined With Metformin on Blood Glucose Control in Subjects With Type 2 Diabetes Inadequately Controlled With Basal InsulinCompletedNCT00669864Phase 4Results posted
• Observational Study to Evaluate the Safety of Levemir® in DiabetesCompletedNCT00659295Results posted
• Effect of Two Different Fasting Blood Glucose Targets on Glucose Control in Patients With Type 2 Diabetes Using Insulin Detemir Once DailyCompletedNCT00634842Phase 4Results posted
• Effect of Biphasic Insulin Aspart 50 on Blood Glucose Control in Subjects With Type 2 DiabetesCompletedNCT00627445Phase 3Results posted
• The Effect of Liraglutide on Endothelial Function in Subjects With Type 2 Diabetes MellitusCompletedNCT00620282Phase 3Results posted
• Effect of Liraglutide or Glimepiride Added to Metformin on Blood Glucose Control in Subjects With Type 2 DiabetesCompletedNCT00614120Phase 3Results posted
• Comparison of Two NN5401 Formulations Versus Insulin Glargine, All in Combination With Metformin in Subjects With Type 2 DiabetesCompletedNCT00614055Phase 2Results posted
• Comparison of Two NN5401 Formulations Versus Biphasic Insulin Aspart 30, All in Combination With Metformin in Subjects With Type 2 DiabetesCompletedNCT00613951Phase 2Results posted
• Comparison of Two NN1250 Formulations Versus Insulin Glargine, All in Combination With Metformin in Subjects With Type 2 DiabetesCompletedNCT00611884Phase 2Results posted
• Comparison of the Blood Sugar Lowering Effect and Safety of Two Insulin Treatments in Type 2 DiabetesCompletedNCT00537303Phase 4Results posted
• Efficacy and Safety of Biphasic Insulin Aspart 30 in Type 2 Diabetes Mellitus When Failing on OADsCompletedNCT00537277Phase 4Results posted
• Effect of Liraglutide or Exenatide Added to an Ongoing Treatment on Blood Glucose Control in Subjects With Type 2 DiabetesCompletedNCT00518882Phase 3Results posted
• Comparison of Insulin Detemir and NPH Insulin Given Once Daily in Ageing Subjects With Type 2 DiabetesTerminatedNCT00506662Phase 4Results posted
• Comparison of Biphasic Insulin Aspart 30 Versus Insulin Glargine Both in Combination With Metformin and Glimepiride in Subjects With Type 2 DiabetesCompletedNCT00469092Phase 4Results posted
• Evaluation of the Glycaemic Control With Insulin Detemir as an add-on to Current Oral Anti-diabetic Drug Treatment in Subjects With Type 2 Diabetes in KoreaCompletedNCT00455858Phase 4Results posted
• Effect of Liraglutide in Combination With Sulfonylurea (SU) on Blood Glucose Control in Subjects With Type 2 DiabetesCompletedNCT00395746Phase 3Results posted
• Effect of Liraglutide on Blood Glucose Control in Subjects With Type 2 DiabetesCompletedNCT00393718Phase 3Results posted
• To Compare the Effect of Liraglutide When Given Together With Metformin With the Effect of Metformin Given Alone and With the Effect of Glimepiride and Metformin Given TogetherCompletedNCT00318461Phase 3Results posted
• To Evaluate the Effect of Liraglutide Versus Glimepiride (Amaryl®) on Haemoglobin A1cTerminatedNCT00294723Phase 3Results posted
• Comparison of Insulin Detemir, Insulin Aspart and Biphasic Insulin Aspart 30 With OAD Treatment in Type 2 DiabetesCompletedNCT00184600Phase 3Results posted
• A Retrospective Real-World Cohort StudyActive, not recruitingNCT07781371
• A Research Study to Compare Two Different Versions of Injectable CagriSema in People With Type 2 DiabetesWithdrawnNCT07357740Phase 2
• A Research Study to See if Two Different Formulations of Oral Semaglutide Are Equally Safe and Effective in Reducing the Blood Sugar Level in Japanese People With Type 2 DiabetesCompletedNCT07271251Phase 3