Novartis: Neoplasm Metastasis trials

The registry lists 52 Neoplasm Metastasis studies with Novartis as lead sponsor. 2 are open to participants now and 15 have results posted.

Phase 1 22Phase 2 16Phase 3 10Phase 4 5No phase 5(a study in two phases counts in both)

Studies

Open to participants first, then studies with results posted, then the rest; newest registration first within each.

• A Study of Real-world Effectiveness of 177Lu-PSMA-617 With and Without Concurrent Androgen Receptor Pathway Inhibitors in Metastatic Castration Resistant Prostate Cancer PatientsNot yet recruitingNCT07928037
• Pluvicto Real-world Investigation in Survival in Metastatic CRPCRecruitingNCT07697989
• Study of Efficacy and Safety of Pembrolizumab Plus Platinum-based Doublet Chemotherapy With or Without Canakinumab in Previously Untreated Locally Advanced or Metastatic Non-squamous and Squamous NSCLC SubjectsTerminatedNCT03631199Phase 3Results posted
• Phase III Study Evaluating Efficacy and Safety of Canakinumab in Combination With Docetaxel in Adult Subjects With Non-small Cell Lung Cancers as a Second or Third Line TherapyTerminatedNCT03626545Phase 3Results posted
• Study of Efficacy and Safety of PDR001 in Patients With Advanced or Metastatic, Well-differentiated, Non-functional Neuroendocrine Tumors of Pancreatic, Gastrointestinal (GI), or Thoracic Origin or Poorly-differentiated Gastroenteropancreatic Neuroendocrine Carcinoma (GEP-NEC)CompletedNCT02955069Phase 2Results posted
• Study of Oral cMET Inhibitor INC280 in Patients With EGFR Wild-type (wt), Advanced Non-small Cell Lung Cancer (NSCLC) (Geometry Mono-1)CompletedNCT02414139Phase 2Results posted
• Study of Efficacy and Safety of Buparlisib (BKM120) Plus Paclitaxel Versus Placebo Plus Paclitaxel in Recurrent or Metastatic Head and Neck Cancer Previously Pre-treated With a Platinum TherapyTerminatedNCT01852292Phase 2Results posted
• A Phase II Study of Everolimus in Combination With Exemestane Versus Everolimus Alone Versus Capecitabine in Advance Breast Cancer.CompletedNCT01783444Phase 2Results posted
• A Phase III Study of BKM120 With Fulvestrant in Patients With HR+,HER2-, AI Treated, Locally Advanced or Metastatic Breast Cancer Who Progressed on or After mTORiTerminatedNCT01633060Phase 3Results posted
• Phase III Study of BKM120/Placebo With Fulvestrant in Postmenopausal Patients With Hormone Receptor Positive HER2-negative Locally Advanced or Metastatic Breast Cancer Refractory to Aromatase InhibitorCompletedNCT01610284Phase 3Results posted
• A Study of the Experimental Drug BKM120 With Paclitaxel in Patients With HER2 Negative, Locally Advanced or Metastatic Breast Cancer, With or Without PI3K ActivationCompletedNCT01572727Phase 2/3Results posted
• An Extension Study to Evaluate the Long Term Safety, Tolerability and Efficacy of Aliskiren Compared to Enalapril in Pediatric Hypertensive Patients 6-17 Years of AgeCompletedNCT01151410Phase 3Results posted
• Effect of Zoledronic Acid as Anti-Cancer Treatment in Metastatic Breast Cancer PatientsCompletedNCT01129336Phase 4Results posted
• Everolimus in Combination With Trastuzumab and Paclitaxel in the Treatment of HER2 Positive Locally Advanced or Metastatic Breast CancerCompletedNCT00876395Phase 3Results posted
• LOGiC - Lapatinib Optimization Study in ErbB2 (HER2) Positive Gastric Cancer: A Phase III Global, Blinded Study Designed to Evaluate Clinical Endpoints and Safety of Chemotherapy Plus LapatinibCompletedNCT00680901Phase 3Results posted
• Efficacy and Safety Study of Panobinostat in Participants With Metastatic Hormone Refractory Prostate CancerCompletedNCT00667862Phase 2Results posted
• Efficacy and Safety of Everolimus in Combination Therapy, in Patients With HER2-overexpressing Metastatic Breast CancerCompletedNCT00426556Phase 1Results posted
• A Real-world Study of Indian Patients With Advanced Breast Cancer Treated With RibociclibCompletedNCT07363434
• A Phase I/II, Dose Finding and Optimization Study of [177Lu]Lu-NeoB in Combination With Capecitabine in Patients With GRPR+, ER+, HER2- Metastatic Breast Cancer After Progression on Previous Endocrine Therapy in Combination With a CDK4/6 Inhibitor.Active, not recruitingNCT06247995Phase 1/2
• Study of HRO761 Alone or in Combination in Cancer Patients With Specific DNA Alterations Called Microsatellite Instability or Mismatch Repair Deficiency.Active, not recruitingNCT05838768Phase 1
• Study of JDQ443 in Patients With Advanced Solid Tumors Harboring the KRAS G12C MutationActive, not recruitingNCT04699188Phase 1/2
• A Study of Select Drug Combinations in Adult Patients With Advanced/Metastatic BRAF V600 Colorectal CancerTerminatedNCT04294160Phase 1
• Study of Safety and Efficacy of Novel Immunotherapy Combinations in Patients With Triple Negative Breast Cancer (TNBC).TerminatedNCT03742349Phase 1
• Study of Oral cMET Inhibitor INC280 in Chinese Patients With EGFR Wild-type Advanced Non-small Cell Lung Cancer (NSCLC)WithdrawnNCT03240393Phase 2
• Treatment of Canadian Men and Pre/Peri/Post-menopausal Women With ER+ Advanced Breast Cancer in the Real-World Setting With Hormone Therapy ± Targeted TherapyCompletedNCT02753686
• A Phase I/Ib Study of NIZ985 in Combination With PDR001 in Adults With Metastatic CancersTerminatedNCT02452268Phase 1
• Phase II Study of Buparlisib + Docetaxel in Advanced or Metastatic Squamous Non-small Cell Lung Cancer (NSCLC) PatientsTerminatedNCT01911325Phase 1
• Safety and Efficacy of FalateScan (Technetium Tc 99m EC20) in Patients With Known Suspected Recurrent or Metastatic Cancer From a Solid TumorCompletedNCT01684098Phase 2
• Phase Ib/II Trial of BEZ235 With Paclitaxel in Patients With HER2 Negative, Locally Advanced or Metastatic Breast CancerTerminatedNCT01495247Phase 1/2
• A Phase Ib/II Study of BEZ235 and Trastuzumab in Patients With HER2-positive Breast Cancer Who Failed Prior to TrastuzumabCompletedNCT01471847Phase 1
• Safety and Efficacy of AEB071 in Metastatic Uveal Melanoma PatientsCompletedNCT01430416Phase 1
• A Single Center Study to Characterize the Absorption, Distribution, Metabolism and Excretion (ADME) of ASA404 After a Single Infusion in Patients With Solid TumorsTerminatedNCT01299701Phase 1
• A Trial of Oral BEZ235 and BKM120 in Combination With Paclitaxel With or Without TrastuzumabCompletedNCT01285466Phase 1
• An Open-label, Dose Escalation Study to Assess the Pharmacokinetics of of ASA404 in Adult Cancer Patients With Impaired Hepatic FunctionTerminatedNCT01278849Phase 1
• A Dose-escalation Pharmacokinetic Study of Intravenous ASA404 in Adult Advanced Cancer Patients With Impaired Renal Function and Patients With Normal Renal FunctionTerminatedNCT01278758Phase 1
• Combination of AUY922 With Trastuzumab in HER2+ Advanced Breast Cancer Patients Previously Treated With TrastuzumabCompletedNCT01271920Phase 1/2
• An Open-label, Dose Escalation Multi-center Study in Patients With Advanced Cancer to Determine the Infusion Rate Effect of ASA 404 With Paclitaxel Plus Carboplatin Regimen or Docetaxel on the Pharmacokietics of Free and Total ASA404TerminatedNCT01240642Phase 1
• Study of EC0489 for the Treatment of Refractory or Metastatic TumorsCompletedNCT00852189Phase 1
• A Phase II Study of EC17 (Folate-hapten Conjugate) in Patients With Progressive Metastatic Renal Cell CarcinomaTerminatedNCT00485563Phase 2
• Study of EC0225 for the Treatment of Refractory or Metastatic TumorsCompletedNCT00441870Phase 1
• Assessment of Pain and Quality of Life in Breast and Prostate Cancer Patients With Bone MetastasesCompletedNCT00434317Phase 4
• Safety of Everolimus in Combination Therapy, in Patients With HER2-overexpressing Metastatic Breast CancerCompletedNCT00426530Phase 1
• Combination Of Lapatinib With Carboplatin, Paclitaxel, and With or Without Trastuzumab In Metastatic Breast Cancer.CompletedNCT00367471Phase 1
• EAP (Expanded Access Protocol) Of Lapatinib Combined With Capecitabine In Metastatic Breast CancerApproved for marketingNCT00338247
• Efficacy and Safety of Zoledronic Acid in Patients With Bone Metastases of Any Solid Tumors or Multiple MyelomaCompletedNCT00219258Phase 3
• Effect of Zoledronic Acid in Patients With Renal Cell Cancer and Bone MetastasisCompletedNCT00172003Phase 4
• Efficacy and Tolerability of Zoledronic Acid With Radiotherapy in Pts With Advanced Osteolytic Bone LesionsCompletedNCT00171964Phase 4
• Study of the Efficacy and Safety of Letrozole Combined With Trastuzumab in Patients With Metastatic Breast CancerTerminatedNCT00171847Phase 4
• Study of the Safety, Tolerability, Pharmacokinetics, and Anti-tumor Effects of Vatalanib in Combination With Capecitabine in Patients With Advanced CancerCompletedNCT00171587Phase 1/2
• EPO906 in Carcinoid and Other Neuroendocrine TumorsCompletedNCT00050349Phase 2
• EPO906 Therapy in Patients With Advanced MelanomaCompletedNCT00035165Phase 2
• Zoledronate in Treating Patients With Solid Tumors That Have Spread to the BoneCompletedNCT00003884Phase 3