National Institute of Allergy and Infectious Diseases (NIAID): Smallpox trials

The registry lists 18 Smallpox studies with National Institute of Allergy and Infectious Diseases (NIAID) as lead sponsor. 0 are open to participants now and 5 have results posted.

Phase 1 10Phase 2 11No phase 1(a study in two phases counts in both)

Studies

Open to participants first, then studies with results posted, then the rest; newest registration first within each.

• Phase II Trial to Assess Safety and Immunogenicity of IMVAMUNE®CompletedNCT01827371Phase 2Results posted
• Lyophilized IMVAMUNE® (1x10^8 TCID50) Versus Liquid IMVAMUNE® (1x10^8 TCID50) Administered Subcutaneously and a Lower Dose Liquid IMVAMUNE® (2x10^7 TCID50) Administered IntradermallyCompletedNCT00914732Phase 2Results posted
• High Dose IMVAMUNE® in Vaccinia-Naive IndividualsCompletedNCT00879762Phase 2Results posted
• MVA Post-Event: Administration Timing and Boost StudyCompletedNCT00437021Phase 1/2Results posted
• ACAM 3000 MVA at Harvard Medical SchoolCompletedNCT00133575Phase 1/2Results posted
• Poly-ICLC to Prevent Respiratory Viral Infections A Safety StudyCompletedNCT00646152Phase 1
• Safety, Reactogenicity and Immunogenicity of MVA in Hematopoietic Stem Cell Transplant (HSCT) SubjectsCompletedNCT00565929Phase 1
• Immune Responses to Smallpox VaccinationCompletedNCT00325975
• Combination Study With MVA BN and DryvaxCompletedNCT00082446Phase 1
• Human Immune Responses SmallpoxCompletedNCT00068198Phase 1
• Dressing Preparations for SmallpoxCompletedNCT00063856Phase 1/2
• Phase I/II Trial of Modified Vaccinia Virus Ankara (MVA) Vaccine Against SmallpoxCompletedNCT00053742Phase 1
• APSV in Vaccinia Naive AdultsCompletedNCT00050518Phase 2
• Expanded Dryvax Dilution Study in Previously Vaccinated AdultsCompletedNCT00050505Phase 2
• Phase I Trial of Smallpox VaccineCompletedNCT00046397Phase 1
• Vaccinia Virus Vaccine (APSV) in Vaccinia- Naive Subjects: PILOTCompletedNCT00038987Phase 1/2
• Dryvax Dilution-Prev Vacc AdultsCompletedNCT00032708Phase 2
• A Study of Dryvax Vaccine Against Smallpox in Previously Unvaccinated AdultsCompletedNCT00026611Phase 2