National Institute of Allergy and Infectious Diseases (NIAID): Diabetes Mellitus, Type 1 trials

The registry lists 25 Diabetes Mellitus, Type 1 studies with National Institute of Allergy and Infectious Diseases (NIAID) as lead sponsor. 1 are open to participants now and 7 have results posted.

Phase 1 4Phase 2 14Phase 3 2No phase 6(a study in two phases counts in both)

Studies

Open to participants first, then studies with results posted, then the rest; newest registration first within each.

• Type 1 Diabetes Extension StudyRecruitingNCT02734277
• Siplizumab in T1DMTerminatedNCT05574335Phase 1/2Results posted
• Tocilizumab (TCZ) in New-onset Type 1 DiabetesCompletedNCT02293837Phase 2Results posted
• A Research Trial of Aralast in New Onset Diabetes (RETAIN)TerminatedNCT01183468Phase 1Results posted
• Inducing Remission in Type 1 Diabetes With AlefaceptTerminatedNCT00965458Phase 2Results posted
• Study of Antithymocyte Globulin for Treatment of New-onset T1DMTerminatedNCT00515099Phase 2Results posted
• Autoimmunity-blocking Antibody for Tolerance in Recently Diagnosed Type 1 DiabetesCompletedNCT00129259Phase 2Results posted
• Islet Transplantation for Type 1 DiabetesCompletedNCT00014911Phase 2Results posted
• 11C-5-HTP PET in Clinical Islet TransplantationCompletedNCT02689479Not applicable
• T and B Cell Responses in Autoimmune DiseasesTerminatedNCT01947036
• Extended Follow-Up After Islet Transplantation in T1DCompletedNCT01369082
• Immunosuppressive Medications for Participants in ITN005CT (NCT00014911)No longer availableNCT01309022
• A Research Trial of Aralast NP in New Onset Diabetes (RETAIN) - Part IIWithdrawnNCT01183455Phase 2
• B-Lymphocyte Immunotherapy in Islet Transplantation for Initial Islet Graft FailureNo longer availableNCT01049633
• Treatment With hOKT3gamma1(Ala-Ala) in T1DMTerminatedNCT00806572Phase 2
• Safety and Effectiveness of Low Molecular Weight Sulfated Dextran in Islet Transplantation After Kidney TransplantWithdrawnNCT00790439Phase 2
• Safety and Effectiveness of Low Molecular Weight Sulfated Dextran in Islet TransplantationCompletedNCT00789308Phase 2
• Proleukin and Rapamune in Type 1 DiabetesCompletedNCT00525889Phase 1
• B-Lymphocyte Immunotherapy in Islet TransplantationTerminatedNCT00468442Phase 2
• LEA29Y (Belatacept) Emory Edmonton ProtocolCompletedNCT00468403Phase 2
• Efficacy of Islet After Kidney TransplantationCompletedNCT00468117Phase 3
• Strategies to Improve Islet SurvivalCompletedNCT00464555Phase 2
• Peritransplant Deoxyspergualin in Islet Transplantation in Type 1 DiabetesCompletedNCT00434850Phase 2
• Islet Transplantation in Type 1 DiabetesCompletedNCT00434811Phase 3
• Evaluation of a Diabetes Vaccine in Newly Diagnosed DiabeticsCompletedNCT00057499Phase 1