Merck KGaA, Darmstadt, Germany: Infertility trials

The registry lists 39 Infertility studies with Merck KGaA, Darmstadt, Germany as lead sponsor. 1 are open to participants now and 17 have results posted.

Phase 1 3Phase 2 7Phase 3 11Phase 4 7No phase 13(a study in two phases counts in both)

Studies

Open to participants first, then studies with results posted, then the rest; newest registration first within each.

• A Study to Compare the Efficacy and Safety of Follitropin Alfa/Lutropin Alfa Versus hMG in Japanese Participants With LH and FSH Deficiency Undergoing ART (HINATA)RecruitingNCT07340827Phase 3
• Efficacy and Safety of Crinone Versus Combination Medication (ACCESS)TerminatedNCT03858049Phase 4Results posted
• Clinical Performance and Safety Investigation of ENDOmetrial Washing MEdical DEvice ForielleTerminatedNCT03387059Phase 4Results posted
• TICON-Day 3, Time Lapse Versus Conventional Method in Day 3 Embryo Culture and AssessmentTerminatedNCT03164551Phase 4Results posted
• Phase 3 Study to Evaluate the Efficacy and Safety of Pergoveris® in Assisted Reproductive Technology (ESPART)CompletedNCT02047227Phase 3Results posted
• Low-dose Gonal-f® in Ovulation InductionTerminatedNCT01871532Phase 4Results posted
• A Trial to Compare the Efficacy and Safety of Ovarian Stimulation With GONAL-f® and Luveris® Starting on Day 1 Versus Day 6 in Women Undergoing Assisted Reproductive TechniqueTerminatedNCT01497197Phase 3Results posted
• A Korean Post-Marketing Surveillance Study On Pergoveris® (Follitropin Alfa + Lutropin Alfa)CompletedNCT01416987Results posted
• SJ-0021 (Gonalef®) Versus Purified Pituitary Gonadotropin (Fertinorm-P®) for Ovulation Induction in Japanese Infertile WomenCompletedNCT01185782Phase 3Results posted
• Convenience and Safety of Assisted Reproductive Technology Procedures Using a Gonal-F Filled by Mass (Fbm) Liquid Formulation Applied by Pen for Ovulation Induction and In-vitro FertilizationCompletedNCT01183143Phase 3Results posted
• A Prospective Study to Evaluate the Addition of Subcutaneous Recombinant Human-Luteinizing Hormone With Recombinant Human-Follicle Stimulating Hormone on Follicular Development in Women Undergoing Ovarian Stimulation for Assisted Reproductive TechnologiesCompletedNCT01121991Phase 3Results posted
• A Randomised, Phase II, Comparative Study With a Parallel Control for Evaluating the Efficacy and Safety of Combined Treatment of Lutropin Alpha and Recombinant Human Luteinizing Hormone in the Middle of the Controlled Ovarian Stimulation Follicular Phase in Women With Reduced Ovarian ReserveCompletedNCT01110707Phase 2Results posted
• A Phase II Study to Assess the Efficacy and Safety of Luveris® (Lutropin Alfa) in Mid Follicular Phase for Controlled Ovarian Stimulation (COS) in Advanced Reproductive AgeTerminatedNCT01079949Phase 2Results posted
• A Clinical Trial to Determine the Effect of Lutropin Alfa on Embryo Quality and Implantation Rate in Advanced Reproductive AgeTerminatedNCT01075815Phase 2Results posted
• Study to Evaluate if the Addition of r-hLH (Luveris®) to FSH From Day 8 of Ovarian Stimulation is Able to Decrease Total FSH Dose and to Improve Cycle Outcome in Infertile Women Undergoing ART, Who Required High FSH Dose in a Previous CycleTerminatedNCT01071200Phase 3Results posted
• CONSORT Randomized Controlled Trial in Assisted Reproductive TechnologyCompletedNCT00829244Phase 4Results posted
• Investigation of a Long-Acting Follicle Stimulating Hormone in Infertile Women Undergoing Assisted Reproductive Technology (ART)CompletedNCT00505752Phase 2Results posted
• Safety and Efficacy of Pre-defined, Fixed Dose of Gonal-f Pen Based on Subject Baseline Characteristics in Subjects Undergoing in Vitro Fertilization (IVF)CompletedNCT00249834Phase 4Results posted
• An Ethno-bridging Study of Pergoveris in Healthy Premenopausal Participants of Japanese or Caucasian OriginCompletedNCT07269327Phase 1
• A Retrospective Study in Chinese Good Prognosis Patients Undergoing Assisted Reproductive Technology (ART) TreatmentCompletedNCT02889380
• A Study to Evaluate Safety and Efficacy of Recombinant Human Luteinizing Hormone (r-hLH) Compared With Urinary Human Chorionic Gonadotrophin (u-hCG) to Trigger Ovulation in Infertile WomenCompletedNCT01735422Phase 2
• A Study to Evaluate the Baseline Follicle Stimulating Hormone, Ovarian Volume and Antral Follicle Count as Prognostic Factors of the Outcome of In-vitro Fertilisation/Intracytosolic Sperm Injection in Infertile Patients Receiving Gonal f for Controlled Ovarian HyperstimulationCompletedNCT01196143
• An Open Label, Canadian Phase IIIb Study With Ovidrel in Ovulation Induction (OI) and Assisted Reproductive Technique (ART)CompletedNCT01152866
• An Observational Study to Evaluate Efficacy, Safety and Clinical Outcomes of Currently Used Pharmaceutical Therapies for Controlled Ovarian Stimulation in Assisted Reproductive TechniquesCompletedNCT01149070
• A Post Marketing Assessment of Gonal f Solution for Injection in a Prefilled Pen for Follicular Stimulation in in Vitro Fertilisation/Embryo Transfer (IVF-ET) CyclesCompletedNCT01125462
• A Study to Evaluate the Ease of Use, Local Tolerance, Safety and Effectiveness of Gonal-f® (Filled-by-mass in a Prefilled Pen)CompletedNCT01115725
• A Non-interventional Study to Identify the Patients With Severe Luteinizing Hormone Deficiency in the Daily PracticeCompletedNCT01112618
• A Prospective, Multi-centric Observational Study to Determine the Mono-bifollicular Development in Infertile Women Subjected to Ovulation Induction With Follitropin αCompletedNCT01111084
• An Observational Study of Cetrotide® Gonadotropin-releasing Hormone Antagonist (GnRH Antagonist) With GONAL-f® in Assisted Reproductive Technologies (ART)CompletedNCT01109654
• Predictive Factors of Ovarian Response in Ovulation Induction With Intrauterine Insemination of a Gonal-f Low-dose RegimenTerminatedNCT01100346
• GONAL-f CONSORT (Consistency in r-hFSH Starting Doses for Individualised Treatment)CompletedNCT01100333
• A Study Using Recombinant Human Chorionic Gonadotrophin (rhCG, Ovidrel®) in the Induction of Final Follicle Maturation and Early Luteinization in Chinese Women Undergoing in Vitro Fertilization and Embryo Transfer (IVF/ET)CompletedNCT01081756Phase 3
• A Study Using Micronised Progesterone (Crinone® 8%) in the Luteal Phase Support of Women Undergoing in Vitro Fertilisation (IVF) and Embryo Transfer (ET)CompletedNCT01081652Phase 3
• To Evaluate the Convenience, Safety and Efficacy of Follitropin Alfa Liquid Pen Compared With Follitropin Beta Liquid PenCompletedNCT01081639Phase 3
• A Phase IV, Prospective, Observational, Open Label, Single Centre Cohort Trial to be Conducted in Norway During One Year to Assess the Cumulative Pregnancy Rate in a New Series of In-vitro Fertilization (IVF) Treatment Cycles Following Three or More Previous IVF Treatment Cycles Without Live BirthCompletedNCT01071148
• A Multicentre, Randomised, Double-blind, Placebo-controlled Proof of Concept Study to Compare the Efficacy and Safety of r-hLIF (Emfilermin) for Improving Embryo Implantation Following in Vitro Fertilization (IVF) and Embryo Transfer (ET) in Women With Recurrent Implantation FailureCompletedNCT00504608Phase 1/2
• r-hLIF for Improving Embryo Implantation in IVFCompletedNCT00504530Phase 1/2
• A Study to Compare the Safety and Efficacy of Cetrotide® 3 Milligram (mg) Versus Antagon™ in Women Undergoing Ovarian StimulationCompletedNCT00298025Phase 4
• A Phase 3b Study to Evaluate Subject Satisfaction With Follitropin Alfa Injection in Oligoanovulatory Infertile Women Undergoing Ovulation InductionCompletedNCT00230815Phase 3