Mclean Hospital: Depression trials

The registry lists 46 Depression studies with Mclean Hospital as lead sponsor. 9 are open to participants now and 16 have results posted.

Early Phase 1 3Phase 1 6Phase 2 5Phase 3 2Phase 4 2No phase 29(a study in two phases counts in both)

Studies

Open to participants first, then studies with results posted, then the rest; newest registration first within each.

• Single Day of Ultra-accelerated TMS With a Single Dose of NRX-101Not yet recruitingNCT07785102Early Phase 1
• Synaptic Mechanisms of Intermittent Theta Burst Stimulation for Major Depressive DisorderNot yet recruitingNCT07593222Phase 1/2
• Synaptic Mechanisms of Continuous Theta Burst Stimulation in DepressionRecruitingNCT07560878Early Phase 1
• Pilot Study of Sensor-Informed Smartphone-based Mental Health Interventions for Mood in Early PsychosisNot yet recruitingNCT07503093Not applicable
• Pharmacologic Augmentation of TMS for Depression With D-serineRecruitingNCT06876129Phase 1
• Stress Dynamics and Familial Risk for Depression in Female AdolescentsRecruitingNCT06816329Not applicable
• Efficacy and Safety of Magnesium Vitamin B6 in First Episode Bipolar DisorderRecruitingNCT05837104Phase 2
• Neural Correlates of Stress and Perceived Control in Adolescent DepressionRecruitingNCT04788524Not applicable
• Early Life Stress and Depression: Molecular and Functional ImagingRecruitingNCT04713722
• LFMS: Initial Trial in Geriatric Bipolar DepressionTerminatedNCT02707276Not applicableResults posted
• Brain Mechanisms of Human MotivationCompletedNCT01976975Results posted
• Multiple Treatment Study Using Low Field Magnetic Stimulation for Bipolar DepressionCompletedNCT01929681Not applicableResults posted
• An Investigation of Early Life Stress and DepressionCompletedNCT01701258Phase 1Results posted
• Exploring the Effects of Coenzyme Q10 on Bioenergetics Metabolism in Geriatric Bipolar DepressionCompletedNCT01390389Not applicableResults posted
• The Effects of Dopamine on Reward ProcessingCompletedNCT01253421Phase 1Results posted
• Lisdexamfetamine Dimesylate in Residual Symptoms and Cognitive Impairment in Major Depressive Disorder.CompletedNCT01148979Phase 4Results posted
• A Trial of SAMe for Treatment-Resistant Bipolar DepressionCompletedNCT00762268Not applicableResults posted
• Lamotrigine Therapy in Geriatric Bipolar DepressionCompletedNCT00720473Not applicableResults posted
• CoQ10 in Geriatric Bipolar DepressionCompletedNCT00720369Not applicableResults posted
• The Use of a Mitochondrial Enhancement Treatment in Bipolar DisorderCompletedNCT00719706Phase 2Results posted
• Low Field Magnetic Stimulation in Mood Disorders Using the LFMS DeviceCompletedNCT00578383Not applicableResults posted
• Riluzole in the Treatment of Bipolar DepressionCompletedNCT00544544Not applicableResults posted
• AndroGel in Men With Major Depression and Incomplete Response to Antidepressant TreatmentCompletedNCT00304746Phase 4Results posted
• Magnetic Resonance Imaging Study of Geriatric DepressionCompletedNCT00245557Not applicableResults posted
• The Effects of Wellbutrin (Bupropion) on Residual and Cognitive Symptoms in SSRI-treated DepressionCompletedNCT00125957Phase 3Results posted
• Novel and Conventional Interventions for Cognitive and Emotional Flexibility in Patient TraumaActive, not recruitingNCT07868627Phase 2
• Effectiveness of HabitWorks and Symptom Tracking for Anxiety and DepressionCompletedNCT07025486Not applicable
• Effects of Attention Training Interventions on DepressionTerminatedNCT04184206Not applicable
• Electronic Media and Its Application in PsychotherapyCompletedNCT03712267Not applicable
• Study of Dronabinol Treatment for Depression and/or Anxiety in Older PatientsWithdrawnNCT03369639
• College Mental Health ProjectStatus unknownNCT03345459Not applicable
• Sex, Hormones and Gamma-Aminobutyric Acid (GABA) in Stress Induced Anhedonia in DepressionCompletedNCT03031665
• Neuroimaging Studies of Reward Processing in DepressionCompletedNCT03026036
• Hippocampal Plasticity of Young Adults With Childhood AdversityCompletedNCT02816502Not applicable
• Proton MRS Study of SSRI-Zolpidem InteractionsCompletedNCT01809626Early Phase 1
• Functional Brain Imaging Study of Response to Repetitive TMS (rTMS) Treatment of Major DepressionStatus unknownNCT01768052
• Genetic and Neural Predictors of Adolescent DepressionCompletedNCT01743716
• Neural Components Underlying the Treatment of Adolescent DepressionCompletedNCT01717508Not applicable
• Depression and Dopamine Transporter Function Study Using C-11 AltropaneCompletedNCT01701141
• Dopamine Neurotransmission in Major DepressionCompletedNCT01659814
• Functional and Neurochemical Correlates of Treatment Response in Major Depressive DisorderTerminatedNCT01598324
• Low Field Magnetic Stimulation (LFMS) in Mood Disorders: 6 TreatmentsSuspendedNCT01557192Phase 1
• Treatment Resistant Geriatric Depression in Primary CareCompletedNCT01392287Phase 1
• Low Field Magnetic Stimulation Treatment for Bipolar DepressionTerminatedNCT00217217Phase 3
• Taurine as an Anti-Manic Agent: A Double-Blind, Placebo-Controlled StudyCompletedNCT00217165Phase 2
• Understanding Brain Reward Responses in Individuals With Major Depressive DisorderCompletedNCT00183755