M.D. Anderson Cancer Center: Colorectal Neoplasms trials

The registry lists 89 Colorectal Neoplasms studies with M.D. Anderson Cancer Center as lead sponsor. 18 are open to participants now and 13 have results posted.

Early Phase 1 1Phase 1 25Phase 2 35Phase 3 1No phase 36(a study in two phases counts in both)

Studies

Open to participants first, then studies with results posted, then the rest; newest registration first within each.

• Phase 1 Study Of SAR445877 In Combination With FOLFOX6 And Bevacizumab As First-Line Treatment For Microsatellite Stable Metastatic Colorectal CancerRecruitingNCT07500298Phase 1
• Dual Administration Of Intraperitoneal And Intravenous TROP2-Directed CAR-NK With TGF-Beta Receptor 2 (TGFBR2) Knock Out (KO) Therapy For Colorectal Cancer-Related Peritoneal Carcinomatosis: A Phase 1/2 Trial ("Chip-CRC Trial")RecruitingNCT07411599Phase 1/2
• ASCEND-CRC: Profiling and Targeting Dynamic Tumor Resistance in Patients With Metastatic Colorectal CancerRecruitingNCT07318389Early Phase 1
• Regorafenib (Reg) and Lorigerlimab (Lor), RELO Regimen, in Treatment of High-risk Patients With Colorectal Cancer With Radiographic Occult Molecular Residual Disease After End of Established Definitive Therapy [ReLOAD Trial]RecruitingNCT07071961Phase 2
• Phase II Study of Anti-PD-1/VEGF Bispecific Antibody Ivonescimab in Patients With Previously Treated Metastatic Colorectal CancerRecruitingNCT06959550Phase 2
• Precision-MRD: Prospective Observational Study of Biomarker-directed Systemic Therapy for Colorectal Cancer Patients With Minimal Residual DiseaseRecruitingNCT06878131
• Trial of AMB-05X for Patients With ctDNA(+) Colorectal Cancer After Curative-intent TreatmentRecruitingNCT06617858Phase 2
• A Multicenter Phase 1b/2 Study of Adagrasib, Cetuximab, and Cemiplimab for Metastatic Colorectal Cancer Harboring KRAS G12C MutationsRecruitingNCT06412198Phase 1/2
• Open-label Phase 1b Study of Ulixertinib and Cetuximab or Ulixertinib in Combination With Cetuximab and Encorafenib in Patients With Unresectable or Metastatic Colorectal Cancer Who Have Previously Received EGFR or BRAF-directed TherapyRecruitingNCT05985954Phase 1
• Connecting Black Families in Houston, Texas to Hereditary Cancer Genetic Counseling, Genetic Testing, and Cascade Testing by Using a Simple Genetic Risk Screening Tool and TelegeneticsRecruitingNCT05694559Not applicable
• Identifying Underserved Individuals inTexas With Hereditary Cancer Risk Using Mobile Mammography Units and Telegenetics.RecruitingNCT05649072Not applicable
• A Phase IIa Randomized, Double-Blinded Clinical Trial of Naproxen or Aspirin for Cancer Immune Interception in Lynch SyndromeRecruitingNCT05411718Phase 2
• An Investigational Scan (Intravoxel Incoherent Motion Diffusion Weighted Imaging) for the Evaluation of Colorectal Cancer Liver Metastases Treatment ResponseRecruitingNCT04796818Not applicable
• Avapritinib for the Treatment of CKIT or PDGFRA Mutation-Positive Locally Advanced or Metastatic Malignant Solid TumorsRecruitingNCT04771520Phase 2
• Minimal Residual Disease Assessment in Patients With Colorectal Cancer, the MiRDA-C StudyRecruitingNCT04739072
• Cryoablation Combined With Stereotactic Body Radiation Therapy for the Treatment of Painful Bone Metastases, the CROME TrialRecruitingNCT04693377Not applicable
• Role of Diet on the Microbiome of the Digestive SystemRecruitingNCT04666727
• Association Between Health Care Provider (HCP)-Assessed ECOG Performance Status (PS) and Overall Survival, and Objectively Measure of Physical Activity (PA) Levels in Advance-cancer Patients"RecruitingNCT01365169Not applicable
• Autologous Tumor Infiltrating Lymphocytes MDA-TIL in Treating Patients With Recurrent or Refractory Ovarian Cancer, Colorectal Cancer, or Pancreatic Ductal AdenocarcinomaTerminatedNCT03610490Phase 2Results posted
• M7824 in Patients With Metastatic Colorectal Cancer or With Advanced Solid Tumors With Microsatellite InstabilityCompletedNCT03436563Phase 1/2Results posted
• Study of Durvalumab (MEDI4736) (Anti-PD-L1) and Trametinib (MEKi) in MSS Metastatic Colon CancerCompletedNCT03428126Phase 2Results posted
• Tremelimumab and Durvalumab in Treating Patients With Colorectal Cancer With Liver Metastases That Can Be Removed by SurgeryCompletedNCT02754856Phase 1Results posted
• Liver Surgery and Chemotherapy in Treating Patients With Colorectal Cancer With Liver Metastases That Can Be Removed by Surgery and Lung Metastases That Cannot Be Removed by SurgeryTerminatedNCT02738606Phase 2Results posted
• Phase II Study of Minocycline for Reducing Symptom Burden in Colorectal PatientsCompletedNCT01906008Phase 2Results posted
• Abraxane in CIMP-High Colorectal and Small Bowel AdenocarcinomasCompletedNCT01730586Phase 2Results posted
• Irinotecan Plus Brivanib in Metastatic Colorectal Cancer (CRC) Enriched for Elevated Levels of Plasma FGFTerminatedNCT01367275Phase 2Results posted
• Azacitidine and CAPOX in Metastatic Colorectal CancerCompletedNCT01193517Phase 1/2Results posted
• Calcium Aluminosilicate Anti-Diarrheal in Treating and Preventing Diarrhea in Patients With Metastatic Colorectal Cancer Receiving IrinotecanCompletedNCT00748215Phase 2Results posted
• Efficacy of the Third Eye Retroscope Auxiliary Imaging SystemCompletedNCT00657371Not applicableResults posted
• Study of FOLFIRI Plus Bevacizumab in Colorectal Cancer PatientsCompletedNCT00354978Phase 2Results posted
• Celecoxib in Preventing Hand/Foot Syndrome Caused By Capecitabine With Metastatic Breast or Colorectal CancerTerminatedNCT00305643Phase 3Results posted
• Phase 2 Trial Of S-531011 With RadScopal In Previously Treated Metastatic Colorectal CancerWithdrawnNCT07720115Phase 2
• A Trial of Regorafenib Plus Lorigerlimab as Neoadjuvant Therapy for Patients With pMMR/MSS, Resectable, Lung-limited Metastatic Colorectal CancerWithdrawnNCT07137390Phase 1/2
• A Phase 2 Trial of Fruquintinib and Tislelizumab in ctDNA-defined Minimal Residual Disease in Colorectal Cancer After Completion of Adjuvant ChemotherapyActive, not recruitingNCT07136077Phase 2
• Dose Escalation and Expansion Study of TROP2 CAR Engineered IL-15- Transduced Cord Blood-derived NK Cells in Combination With Cetuximab in Patient With Colorectal Cancer (CRC) With Minimal Residual Disease (MRD)Active, not recruitingNCT06358430Phase 1
• Regorafenib and XmAb20717 in Treatment of High-risk Patients With Colorectal Cancer With Radiographic Occult Molecular Residual Disease After End of Established Definitive Therapy (RX-CROME)WithdrawnNCT05900648Phase 2
• Phase I Trial of Adagrasib (MRTX849) in Combination With Cetuximab and Irinotecan in Patients With Colorectal CancerActive, not recruitingNCT05722327Phase 1
• TAS-102 With or Without Celecoxib in ctDNA-defined Minimal Residual Disease in Colorectal Cancer After Completion of Adjuvant ChemotherapyActive, not recruitingNCT05343013Phase 2
• Magnetic Particle-ICG Lymph Node Mapping in Colorectal CancerWithdrawnNCT05092750Phase 1/2
• Psychological, Psychophysical and Epigenetic Determinants of Chronic Pain After Cytoreductive - Hyperthermic Intraoperative ChemotherapyCompletedNCT05083338
• An Investigational Scan (MR DENSE) in Detecting Early Chemotherapy-Related Liver Injury Before Surgery in Patients With Resectable Colorectal Liver MetastasesWithdrawnNCT05059717Not applicable
• DAILY: Vitamin D, Aspirin, ExercIse, Low Saturated Fat Foods StudY in Colorectal Cancer Patients With Minimal Residual DiseaseCompletedNCT05036109Not applicable
• Fecal Microbiota Transplant and Re-introduction of Anti-PD-1 Therapy (Pembrolizumab or Nivolumab) for the Treatment of Metastatic Colorectal Cancer in Anti-PD-1 Non-respondersActive, not recruitingNCT04729322Phase 2
• LY3214996 and Cetuximab Alone or in Combination With Abemaciclib for the Treatment of Unresectable or Metastatic Colorectal CancerActive, not recruitingNCT04616183Phase 1/2
• SX-682 and Nivolumab for the Treatment of RAS-Mutated, MSS Unresectable or Metastatic Colorectal Cancer, the STOPTRAFFIC-1 TrialActive, not recruitingNCT04599140Phase 1/2
• Microwave Ablation or Wedge Resection for the Treatment of Lung, Sarcoma and Colorectal Lesions, ALLUME StudyActive, not recruitingNCT04430725
• Encorafenib, Cetuximab, and Nivolumab in Treating Patients With Microsatellite Stable, BRAFV600E Mutated Unresectable or Metastatic Colorectal CancerActive, not recruitingNCT04017650Phase 1/2
• Circulating Cell-Free Tumor DNA Testing in Guiding Treatment for Patients With Advanced or Metastatic Colorectal CancerActive, not recruitingNCT03844620Phase 2
• Chemotherapy and/or Metastasectomy in Treating Patients With Metastatic Colorectal Adenocarcinoma With Lung MetastasesActive, not recruitingNCT03599752Phase 2
• Utomilumab, Cetuximab, and Irinotecan Hydrochloride in Treating Patients With Metastatic Colorectal CancerCompletedNCT03290937Phase 1
• Glutamine PET Imaging Colorectal CancerTerminatedNCT03275974Phase 1
• Colorectal Cancer (CRC) Surveillance Tool: Cognitive and Pilot TestingCompletedNCT03180411
• Lesion Detection Assessment in the Liver: Standard vs Low Radiation Dose Using Varied Post-Processing TechniquesActive, not recruitingNCT03151564Not applicable
• Decision Aid Website in Helping to Make Decisions About Fertility in Participants With CancerActive, not recruitingNCT03141437Not applicable
• Panitumumab With or Without Trametinib in Treating Patients With Stage IV Colorectal CancerActive, not recruitingNCT03087071Phase 2
• Danvatirsen and Durvalumab in Treating Patients With Advanced and Refractory Pancreatic, Non-Small Cell Lung Cancer, and Mismatch Repair Deficient Colorectal CancerActive, not recruitingNCT02983578Phase 2
• Molecular Determinants of Response to Preoperative Therapy in Patients With Locally Advanced Colorectal CancerStatus unknownNCT02877056
• Young-Onset Colorectal CancerActive, not recruitingNCT02863107
• CD8+ T Cell Therapy and Pembrolizumab in Treating Patients With Metastatic Gastrointestinal TumorsTerminatedNCT02757391Phase 1
• Non-Surgical Management of Attenuated and Deleterious (Classical) Familial Adenomatous Polyposis: A Long-term Surveillance ProgramCompletedNCT02747862
• Accelerated Enhanced RECOVERy Following Minimally Invasive Colorectal Cancer Surgery (RecoverMI)CompletedNCT02613728Not applicable
• Personalized Peptide Vaccine in Treating Patients With Advanced Pancreatic Cancer or Colorectal CancerActive, not recruitingNCT02600949Phase 1
• Patient-Centered Risk Adjusted Surveillance After Curative Resection of Colorectal CancerCompletedNCT02217865
• Using Multimedia Approaches to Communicate Probabilities in Patient Decision Aids for Low-Literacy Populations: Randomized TrialCompletedNCT02151032
• Escalating Doses of Oxaliplatin and Hyperthermic Intraperitoneal Chemotherapy (HIPEC) in Children and Adolescents With Extensive Colon CarcinomaCompletedNCT02062749Phase 1
• An Open-Labeled Pilot Study of Biomarker Response Following Short-Term Exposure to MetforminTerminatedNCT01816659Phase 1
• Vemurafenib, Cetuximab, and Irinotecan Hydrochloride in Treating Patients With Solid Tumors That Are Metastatic or That Cannot Be Removed by SurgeryCompletedNCT01787500Phase 1
• R-21 Colorectal Cancer Screening (CRCS) Pilot TrialCompletedNCT01492049Not applicable
• The Molecular Predisposition to Hereditary Nonpolyposis Colon Cancer (HNPCC)Status unknownNCT01447199
• Colorectal Cancer Umbrella Protocol - Assessment of Targeted Therapies Against Colorectal Cancer (ATTACC Program) Screening ProtocolCompletedNCT01196130
• 4D PET/CT in Diagnosing Participants With Lung and Colorectal Cancer With Liver and Lung MetastasisCompletedNCT00862680
• Expressive Disclosure and Colorectal CancerStatus unknownNCT00853203
• Colon Cancer Screening in First-Degree Relatives of Hispanic Colorectal Cancer (CRC) PatientsCompletedNCT00838318
• Formative Study of Tailored Survivor Health PromotionCompletedNCT00825240
• Longitudinal Study of Symptoms in Colorectal CancerTerminatedNCT00777192
• Yttrium Microspheres With Cetuximab Plus Irinotecan for Patients With Advanced Colorectal Cancer Mets to LiverWithdrawnNCT00766220Phase 2
• Celecoxib in Preventing Colorectal Cancer in Young Patients With a Genetic Predisposition for Familial Adenomatous PolyposisCompletedNCT00685568Phase 1
• Screening for Familial Colorectal Cancer (CRC) PatientsCompletedNCT00632515
• Multimedia Intervention in Patients With Familial Adenomatous Polyposis (FAP)CompletedNCT00525655Not applicable
• Registry for Women Who Are At Risk Or May Have Lynch SyndromeCompletedNCT00508573
• Ambulatory Cancer Pain Management: A Feasibility StudyCompletedNCT00507351
• Assessment of Symptom-Related Cytokines in Lung and Gastrointestinal (GI) Cancer PatientsCompletedNCT00502502
• FOLFOX Chemotherapy Regimen (5-FU, Leucovorin, Oxaliplatin) in Metastatic Colorectal CancerCompletedNCT00501410Phase 1
• Cancer Prevention and Treatment Demonstration for Ethnic and Racial MinoritiesCompletedNCT00453661
• Comparison of Sulindac, Aspirin, and Ursodiol in Preventing Colorectal CancerTerminatedNCT00062023Phase 2
• SCH 66336 Before Surgery in Treating Patients With Colorectal Cancer That Has Metastasized to the LiverWithdrawnNCT00005030Phase 1
• Radiofrequency Ablation Followed By Hepatic Artery Chemotherapy in Treating Patients With Colorectal Cancer That Has Spread to the LiverCompletedNCT00004142Phase 2
• Irofulven in Treating Patients With Metastatic Colorectal CancerCompletedNCT00003441Phase 2
• Interleukin-12 in Treating Patients With Cancer in the AbdomenCompletedNCT00003046Phase 1