Imperial College London: Pulmonary Disease, Chronic Obstructive trials

The registry lists 37 Pulmonary Disease, Chronic Obstructive studies with Imperial College London as lead sponsor. 4 are open to participants now and 10 have results posted.

Phase 2 3Phase 3 3Phase 4 4No phase 27(a study in two phases counts in both)

Studies

Open to participants first, then studies with results posted, then the rest; newest registration first within each.

• Using Multiomics to Define Mechanisms of Rhinovirus-induced Chronic Obstructive Pulmonary Disease Exacerbations to Develop Novel Therapies and Therapeutic TargetsRecruitingNCT07112235
• Exploring How Viral Infections Affect People With Chronic Lung DiseaseRecruitingNCT06625944
• Activity, Balance and COPD (ABCOPD)RecruitingNCT04006015
• The London COPD Exacerbation CohortRecruitingNCT02755974
• Metformin to Reduce Airway Glucose in COPD PatientsCompletedNCT03651895Phase 2Results posted
• Airway Effects of Tiotropium in Patients With COPDCompletedNCT02683668Phase 3Results posted
• A Study to Evaluate the Anti-inflammatory Effects of Solithromycin in Chronic Obstructive Pulmonary DiseaseTerminatedNCT02628769Phase 2Results posted
• Targeted Retreatment of COPD ExacerbationsCompletedNCT02300220Phase 3Results posted
• Acute Effects of a Flutter Device in COPDCompletedNCT01832961Not applicableResults posted
• Effect of Symbicort ® on GR in Sputum in COPDCompletedNCT01787097Phase 4Results posted
• Inhaler Lung Deposition in Chronic Obstructive Pulmonary Disease (COPD)CompletedNCT01721291Phase 4Results posted
• Comparison of Repetitive Magnetic Stimulation and Exercise on Quadriceps Function in COPDCompletedNCT00737698Not applicableResults posted
• Macrophage Phagocytosis in COPDCompletedNCT00298389Results posted
• Enhancement of in-Vitro GC Function in Patients With COPDCompletedNCT00241631Phase 2Results posted
• Physiology and Structure of the Small Airways in Patients With Chronic Airflow Obstruction or COVID-19Status unknownNCT04716023
• London Underground Study - Health Effects of Particulate MatterCompletedNCT04614064Not applicable
• The BLF Early COPD Development Partnership GrantStatus unknownNCT03480347
• Effects of Long Term Antibiotic Therapy on Exacerbation Rate in Stable COPD PatientsCompletedNCT02305940Phase 3
• Auto-titrating Oxygen in Chronic Respiratory FailureCompletedNCT02248064Not applicable
• Characteristics That Identify Exacerbation Risk Following Colds in COPD PatientsCompletedNCT01376830
• Angiotensin-converting Enzyme (ACE)-Inhibition and Mechanisms of Skeletal Muscle Weakness in Chronic Obstructive Pulmonary Disease (COPD)CompletedNCT01014338Phase 4
• Osteoprotegerin (OPG) in Induced Chronic Obstructive Pulmonary Disease (COPD) SputumCompletedNCT00655954
• Genomic/ Proteomic/ Metabonomic Profiling in Chronic Obstructive Pulmonary Disease (COPD)WithdrawnNCT00655694
• Systemic Endothelial Abnormalities in COPDWithdrawnNCT00555529
• Inhaled Mannitol and Ciliary Beat Frequency in COPD PatientsWithdrawnNCT00446121
• Macrophages in Smokers' LungWithdrawnNCT00298402
• Effect of Symbicort on HAT and HDAC in Sputum Macrophages of COPDWithdrawnNCT00291408Phase 4
• Assessment of Ventilation-perfusion Abnormalities in Patients With Stable Smoking-related Airways DiseaseTerminatedNCT00180843Not applicable
• Regulation of the Release of Inflammatory Mediators From Blood LeukocytesWithdrawnNCT00180765
• NO Donors and Inhibitors to Study Imbalance of Nitrogen Stress and Antioxidant Defense in COPDCompletedNCT00180635Not applicable
• Markers for Chronic Obstructive Pulmonary Disease (COPD)WithdrawnNCT00180622
• The Use of Repetitive Magnetic Stimulation for Strength Training of the Quadriceps MuscleCompletedNCT00159367Not applicable
• ATP/AMP Challenge in Healthy Non-smokers, Smokers, Patients With Asthma, and Patients With Chronic Obstructive Pulmonary Disease (COPD)CompletedNCT00159315Not applicable
• Endotoxin and Inflammatory Markers in Healthy Non-Smokers and Current Smokers Including Patients With Chronic Obstructive Pulmonary Disease (COPD)WithdrawnNCT00159289Not applicable
• GR Defect in Sputum Cells in COPDWithdrawnNCT00159276
• GR Defect in Peripheral Blood Mononuclear Cells in COPDWithdrawnNCT00159237
• Regulation of Inflammatory Mediators in Chronic Obstructive Pulmonary DiseaseCompletedNCT00147095