GlaxoSmithKline: Arthritis, Rheumatoid trials

The registry lists 44 Arthritis, Rheumatoid studies with GlaxoSmithKline as lead sponsor. 1 are open to participants now and 17 have results posted.

Phase 1 14Phase 2 19Phase 3 8No phase 5(a study in two phases counts in both)

Studies

Open to participants first, then studies with results posted, then the rest; newest registration first within each.

• A Study of GSK5926371 in Participants With B-cell Driven Autoimmune Rheumatic Diseases (ARD)RecruitingNCT07371468Phase 1
• Long-term Safety and Efficacy of GSK3196165 (Otilimab) in the Treatment of Rheumatoid Arthritis (RA)TerminatedNCT04333147Phase 3Results posted
• Efficacy and Safety of GSK3196165 (Otilimab) Versus Placebo and Sarilumab in Participants With Moderately to Severely Active Rheumatoid Arthritis Who Have an Inadequate Response to Biological Disease-modifying Antirheumatic Drug (DMARDs) and/or Janus Kinase (JAK) InhibitorsCompletedNCT04134728Phase 3Results posted
• Efficacy and Safety of GSK3196165 Versus Placebo and Tofacitinib in Participants With Moderately to Severely Active Rheumatoid Arthritis Who Have an Inadequate Response to MethotrexateCompletedNCT03980483Phase 3Results posted
• Efficacy and Safety of GSK3196165 Versus Placebo and Tofacitinib in Participants With Moderately to Severely Active Rheumatoid Arthritis Who Have an Inadequate Response to Conventional Synthetic (cs)/Biologic (b) Disease Modifying Anti-rheumatic Drugs (DMARDs)TerminatedNCT03970837Phase 3Results posted
• First-time-in-Human (FTIH) Study to Evaluate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single (in Both Fed and Fasted States) or Repeat Doses of GSK3358699TerminatedNCT03426995Phase 1Results posted
• Lipopolysaccharide (LPS) or Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) Challenge Study on Healthy SubjectsCompletedNCT03306589Phase 1Results posted
• Evaluation of Pharmacokinetics and Safety of GSK3196165 in Combination With Methotrexate in Japanese Subjects With Rheumatoid ArthritisCompletedNCT03028467Phase 1/2Results posted
• Efficacy, Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of GSK3117391 in Subjects With Rheumatoid ArthritisTerminatedNCT02965599Phase 2Results posted
• Safety and Tolerability, Pharmacokinetics (PK), Pharmacodynamics (PD) and Efficacy of Repeat Doses of GSK2982772 in Subjects With Moderate to Severe Rheumatoid Arthritis (RA)CompletedNCT02858492Phase 2Results posted
• Mechanistic Study of GSK3196165 Plus Methotrexate (MTX) in Subjects With Active Rheumatoid ArthritisCompletedNCT02799472Phase 2Results posted
• Study to Evaluate the Efficacy and Safety of GSK3196165 Plus Methotrexate in Subjects With Active Moderate-Severe Rheumatoid ArthritisCompletedNCT02504671Phase 2Results posted
• This Study is Randomised, Single Oral Dose Bioequivalence Study of Meloxicam GSK 15 MG Tablets.CompletedNCT01750931Not applicableResults posted
• Long-term Efficacy and Safety of Repeated Ofatumumab Treatment Courses in RA Patients Who Previously Received Ofatumumab or Placebo in Trial Hx-CD20-403TerminatedNCT00655824Phase 2Results posted
• Investigating Clinical Efficacy of Ofatumumab in Adult Rheumatoid Arthritis (RA) Patients Who Had an Inadequate Response to MTX TherapyTerminatedNCT00611455Phase 3Results posted
• Investigating Clinical Efficacy of Ofatumumab in Adult Rheumatoid Arthritis (RA) Patients Who Had an Inadequate Response to TNF-α Antagonist TherapyTerminatedNCT00603525Phase 3Results posted
• A Continuation Trial for Subjects With Rheumatoid Arthritis That Have Completed Protocol LBRA01TerminatedNCT00583557Phase 2Results posted
• A Safety and Efficacy Study of LymphoStat-B™ (Monoclonal Anti-BLyS Antibody) in Subjects With Rheumatoid Arthritis (RA)CompletedNCT00071812Phase 2Results posted
• A Study in Healthy Japanese Participants to Evaluate the Safety and Pharmacokinetics of OtilimabWithdrawnNCT05304130Phase 1
• Subject Insights to Understand Rheumatoid Arthritis (RA)CompletedNCT03285191
• A Study to Assess Inflammation in Rheumatoid Arthritis Using Molecular Imaging TechniquesTerminatedNCT02350426Phase 1
• Phase 1 Dose Escalating Study to Assess Safety, Tolerability, Food Effect and PK of CHR-5154 in Healthy Male VolunteersTerminatedNCT01934101Phase 1
• Repeat Dose Subcutaneous Rhumatoid Arthritis Efficacy StudyCompletedNCT01101555Phase 1
• Safety, Pharmacodynamics and Pharmacokinetics of GSK2136525 Repeat Dose in Rheumatoid ArthritisTerminatedNCT01077531Phase 1
• A Study to Investigate the Ability of GSK706769 to Maintain Clinical Remission After Withdrawal of Enbrel in Rheumatoid Arthritis PatientsWithdrawnNCT00979771Phase 2
• Expanded Access Trial of Belimumab Antibody in RA Patients Who Were Previously Treated Under HGS Protocol LBRA99No longer availableNCT00931086
• Study to Evaluate SC Route of Administration of Ofatumumab in RA PatientsCompletedNCT00686868Phase 1
• Phase II Study Evaluating the Safety and Efficacy of GSK315234A in Patients With Rheumatoid ArthritisCompletedNCT00674635Phase 2
• A Phase I Rheumatoid Arthritis Study in Healthy VolunteersCompletedNCT00539760Phase 1
• A Study to Examine the Effect of Particle Size on Bioequivalence and BioavailabilityCompletedNCT00517543Phase 1
• A Study To Look At The Safety Of SB-681323 In Healthy Adult Subjects After Intravenous Administration Of A Single DoseCompletedNCT00439881Phase 1
• SB-681323-Methotrexate Interaction StudyCompletedNCT00419809Phase 1
• A Study To Investigate The Effect Of 28 Days Of Dosing With GW856553 On Patients With Rheumatoid ArthritisCompletedNCT00393146Phase 2
• A Study To Investigate GW274150 Or Prednisolone In Rheumatoid Arthritis Taken Repeatedly For 28 Days.CompletedNCT00379990Phase 2
• The Anti-Inflammatory And Metabolic Effects Of Rosiglitazone In Subjects With Rheumatoid ArthritisCompletedNCT00379600Phase 2
• Study Of 90mg Of GW274150 In Subjects Over 50 Years, Who Have Rheumatoid Arthritis (RA)CompletedNCT00370435Phase 2
• Effects Of Prednisolone On Rheumatoid Arthritis PatientsCompletedNCT00330889
• SB-681323 In Subjects With Rheumatoid ArthritisCompletedNCT00320450Phase 2
• HuMax-CD20 in Active Rheumatoid Arthritis, Phase I/IICompletedNCT00291928Phase 2
• Single Dose Study Of GW856553 On A Protein That Is An Indicator For Rheumatoid Arthritis (RA)CompletedNCT00256919Phase 2
• A Study To Investigate Markers Of Inflammation In Rheumatoid ArthritisCompletedNCT00242853
• A Single Dose Of Compound SB-681323 Compared To Prednisolone On A Protein That Is an Indicator For Rheumatoid ArthritisCompletedNCT00134693Phase 2
• COX-2 Inhibitor Study In Patients With Rheumatoid ArthritisCompletedNCT00113308Phase 3
• Study of the Safety and Efficacy of NC-503 in Secondary (AA) AmyloidosisCompletedNCT00035334Phase 2/3