Gilead Sciences: Hepatitis B trials

The registry lists 48 Hepatitis B studies with Gilead Sciences as lead sponsor. 0 are open to participants now and 31 have results posted.

Phase 1 5Phase 2 17Phase 3 15Phase 4 4No phase 8(a study in two phases counts in both)

Studies

Open to participants first, then studies with results posted, then the rest; newest registration first within each.

• Study to Evaluate the Safety, Tolerability, and Antiviral Activity of Selgantolimod (Formerly GS-9688) in Viremic Adult Participants With Chronic Hepatitis B (CHB) Who Are Not Currently on TreatmentCompletedNCT03615066Phase 2Results posted
• Safety and Efficacy of Bictegravir/Emtricitabine/Tenofovir Alafenamide Versus Dolutegravir + Emtricitabine/Tenofovir Disoproxil Fumarate in Treatment Naive, HIV-1 and Hepatitis B Co-Infected AdultsCompletedNCT03547908Phase 3Results posted
• Safety, Tolerability and Antiviral Activity of Selgantolimod in Virally-Suppressed Participants With Chronic Hepatitis BCompletedNCT03491553Phase 2Results posted
• Study to Evaluate the Safety and Antiviral Activity of Inarigivir Soproxil (Formerly: GS-9992) Plus Tenofovir Alafenamide (TAF) for 12 Weeks in Adults With Chronic Hepatitis B (CHB)TerminatedNCT03434353Phase 2Results posted
• Study to Evaluate the Safety and Efficacy of Switching to Tenofovir Alafenamide (TAF) From Tenofovir Disoproxil Fumarate (TDF) and/or Other Oral Antiviral Treatment (OAV)CompletedNCT03180619Phase 2Results posted
• Study to Evaluate Efficacy and Safety of Switching From TDF to TAF in Adults With Chronic Hepatitis B Who Are Virologically SuppressedCompletedNCT02979613Phase 3Results posted
• Efficacy and Safety of Tenofovir Alafenamide (TAF) Versus Tenofovir Disoproxil Fumarate (TDF)-Containing Regimens in Participants With Chronic Hepatitis B Virus (HBV) Infection and Stage 2 or Greater Chronic Kidney Disease Who Have Received a Liver TransplantCompletedNCT02862548Phase 2Results posted
• Tenofovir Alafenamide Versus Tenofovir Disoproxil Fumarate for Treatment of Hepatitis B e Antigen-Positive Hepatitis B (China)CompletedNCT02836249Phase 3Results posted
• Tenofovir Alafenamide Versus Tenofovir Disoproxil Fumarate for Treatment of Hepatitis B e Antigen-Negative Hepatitis B (China)CompletedNCT02836236Phase 3Results posted
• Study to Evaluate the Safety, Tolerability, and Efficacy of Vesatolimod in Combination With Tenofovir Disoproxil Fumarate (TDF) in Adults With Chronic Hepatitis B (CHB) Infection Who Are Currently Not Being TreatedCompletedNCT02579382Phase 2Results posted
• Utilization and Efficacy of Tenofovir DF in Adolescents With Chronic Hepatitis B Virus InfectionTerminatedNCT02479880Phase 4Results posted
• Study to Evaluate the Pharmacokinetics of Tenofovir Alafenamide (TAF) in Adults With Normal Hepatic Function and Adults With Severe Hepatic ImpairmentCompletedNCT02296853Phase 1Results posted
• Safety and Efficacy of GS-4774 in Combination With Tenofovir Disoproxil Fumarate (TDF) for the Treatment of Participants With Chronic Hepatitis B (CHB) and Who Are Currently Not on TreatmentCompletedNCT02174276Phase 2Results posted
• Study To Evaluate Safety and Efficacy of Vesatolimod for the Treatment of Chronic Hepatitis B Virus in Virally-Suppressed ParticipantsCompletedNCT02166047Phase 2Results posted
• Efficacy and Safety of E/C/F/TAF (Genvoya®) in HIV-1/Hepatitis B Co-infected AdultsCompletedNCT02071082Phase 3Results posted
• Safety and Efficacy of GS-4774 for the Treatment of Chronic Hepatitis BCompletedNCT01943799Phase 2Results posted
• Study to Compare Tenofovir Alafenamide (TAF) Versus Tenofovir Disoproxil Fumarate (TDF) in Participants With Chronic Hepatitis B Infection Who Are Positive for Hepatitis B e AntigenCompletedNCT01940471Phase 3Results posted
• Study to Compare Tenofovir Alafenamide (TAF) Versus Tenofovir Disoproxil Fumarate (TDF) in Participants With Chronic Hepatitis B Infection Who Are Negative for Hepatitis B e AntigenCompletedNCT01940341Phase 3Results posted
• Stopping TDF Treatment After Long Term Virologic Suppression in HBeAg-negative CHBCompletedNCT01320943Phase 4Results posted
• Efficacy & Safety of Tenofovir Disoproxil Fumarate (TDF) Plus Peginterferon α-2a (Peg-IFN) Versus TDF or Peg-IFN Monotherapy in Chronic Hepatitis BCompletedNCT01277601Phase 4Results posted
• Rollover Protocol Continued Access to Emtricitabine/Tenofovir Disoproxil Fumarate for Adults in United StatesCompletedNCT00936715Phase 2Results posted
• Tenofovir Disoproxil Fumarate (Tenofovir DF) Versus Emtricitabine/Tenofovir DF in Subjects Resistant to LamivudineCompletedNCT00737568Phase 3Results posted
• A Study to Evaluate Tenofovir Disoproxil Fumarate (DF) in Asian-American Adults With Chronic Hepatitis B InfectionCompletedNCT00736190Phase 4Results posted
• Evaluation of Tenofovir Disoproxil Fumarate in Adolescents With Chronic Hepatitis B InfectionCompletedNCT00734162Phase 3Results posted
• Truvada Versus Truvada Plus Hepatitis B Immunoglobulin (HBIg) in Prevention of Chronic Hepatitis B Recurrence Post Liver TransplantCompletedNCT00507689Phase 2Results posted
• A Study to Compare Tenofovir DF Versus the Combination of Emtricitabine Plus Tenofovir DF for the Treatment of Chronic Hepatitis B in Patients With Normal Alanine Aminotransferase (ALT)CompletedNCT00507507Phase 2Results posted
• Treatment of Persistent Viremia (Virus in Blood) in Chronic Hepatitis B Subjects Already Receiving Adefovir DipivoxilCompletedNCT00307489Phase 2Results posted
• Study Comparing Tenofovir Disoproxil Fumarate (TDF), Emtricitabine (FTC)/TDF, and Entecavir (ETV) in the Treatment of Chronic HBV in Subjects With Decompensated Liver Disease.CompletedNCT00298363Phase 2Results posted
• A Study to Compare Tenofovir Disoproxil Fumarate Versus Adefovir Dipivoxil for the Treatment of HBeAg-Negative Chronic Hepatitis BCompletedNCT00117676Phase 3Results posted
• A Study to Compare Tenofovir Disoproxil Fumarate Versus Adefovir Dipivoxil for the Treatment of HBeAg-Positive Chronic Hepatitis BCompletedNCT00116805Phase 3Results posted
• Safety and Efficacy of Adefovir Dipivoxil in Children and Adolescents With Chronic Hepatitis BCompletedNCT00095121Phase 3Results posted
• Long Term Follow-up Registry of Individuals Treated in A Gilead-Sponsored Trial in Individuals With Chronic Hepatitis B InfectionTerminatedNCT02258581
• Observational Study on Prevalence of Host and Viral Genotypes in Chronic Hepatitis B and Hepatitis C Patients in IndiaCompletedNCT01772121
• A Phase 1b Study Assessing GS-7340 in Treatment-Naive Adults With Chronic Hepatitis BCompletedNCT01671787Phase 1
• A Study Evaluating GS-9620 in Virologically Suppressed Subjects With Chronic Hepatitis B Virus InfectionCompletedNCT01590654Phase 1
• A Study Evaluating GS-9620 in Treatment Naive Subjects With Chronic Hepatitis BCompletedNCT01590641Phase 1
• Registry Study for Patients With Chronic HBV Receiving Nucleotide TherapyCompletedNCT01590615
• Rollover Protocol Continued Access to Tenofovir Disoproxil Fumarate (TDF) for Subjects in TaiwanCompletedNCT01334567Phase 2
• CHARM: Chronic Hepatitis B Antihepadnaviral Resistance Mutation StudyCompletedNCT00645736
• Open Label Study of Pharmacokinetics and Safety of Dose of Adefovir Dipivoxil in Children and Adolescents With HBVCompletedNCT00645294Phase 1/2
• PK Study of Tacrolimus and Cyclosporine When Co-Administered With Adefovir Dipivoxil in Post-Liver Transplant PatientsCompletedNCT00644761Phase 2
• Efficacy and Safety of Clevudine Compared With Adefovir in Patients With Chronic Hepatitis Due to Hepatitis B VirusTerminatedNCT00496158Phase 3
• Efficacy and Safety of Clevudine Compared With Adefovir in Patients With HBeAg Positive Chronic Hepatitis Due to Hepatitis B VirusTerminatedNCT00496002Phase 3
• Evaluation of Chronic HBV Patients w/Evidence of HBV Replication and Normal or Minimally Elevated Liver Transaminases.CompletedNCT00263614
• Observational Study of the Durability of Seroconversion Chronic HBV Patients Who Seroconverted in a Previous Gilead-Sponsored Study of ADV.CompletedNCT00158717
• Continued Access Study of Adefovir Dipivoxil (ADV) for Patients w/Chronic HBV Infection.TerminatedNCT00158704Not applicable
• Evaluate Efficacy, Safety and PK of Adefovir Dipivoxil Liquid Suspension in Patients With Chronic Hepatitis BCompletedNCT00071201Phase 3
• An Open-Label Program of Adefovir Dipivoxil in the Treatment of Patients With Lamivudine-Resistant Chronic Hepatitis B With Limited Treatment OptionsApproved for marketingNCT00042393