Loxo Oncology, Inc. clinical trials
Acquired by Eli Lilly and Company, Feb 15, 2019 · source ↗
The registry lists 17 studies whose lead sponsor is Loxo Oncology, Inc.. 2 are recruiting or about to start. Per ClinicalTrials.gov, last updated Nov 4, 2026.
- 17studies on the registry
- 2open to participants now
- 6phase 3 studies under way
- 2reach primary completion within a year
Before and after it joined Eli Lilly and Company
- First submitted before Loxo Oncology, Inc. became part of Eli Lilly and Company
- 1
- First submitted after Loxo Oncology, Inc. became part of Eli Lilly and Company
- 16
- Unclear, or no submission date
- 0
By the date each study was first submitted to the registry. The registry lists today's sponsor name and keeps no history, so this says when a study was filed, not who filed it.
What it is testing
The drugs Loxo Oncology, Inc.’s studies test, most open studies first — 3 drugs with a page of their own. Each count opens the studies in search.
Open now Not open: under way, finished or stopped
- pirtobrutinib5 in phase 32 open · 11
- selpercatinib1 in phase 30 open · 5
- 0 open · 1
Coming up
2 of Loxo Oncology, Inc.’s studies under way reach primary completion within a year, all of them phase 3. The dates are the sponsor’s own estimates, which often move.
Phase 3 Other phases
- NNov ’26’26
- DDec
- JJan ’27’27
- FFeb
- MMar
- AApr
- MMay
- JJun
- JJul
- AAug
- SSep
- 1OOct
- 1NNov
All 2
- Oct 2027A Study of Pirtobrutinib (LOXO-305) Versus Ibrutinib in Participants With Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL)pirtobrutinib · Phase 3 · NCT05254743
- Nov 2027Study of BTK Inhibitor LOXO-305 Versus Approved BTK Inhibitor Drugs in Patients With Mantle Cell Lymphoma (MCL)pirtobrutinib · Phase 3 · NCT04662255
Add all 2 to your calendar (.ics) → With an account.
All 17 at a glance
Where each study is in its life, its phase and its countries. Each count opens them in search.
Over the years
- 19
- 20
- 721
- 22
- 23
- 24
- 25
- 026
By the year each study started. 2026 so far in the lighter column.
Registry sponsor names on this page
- Loxo Oncology, Inc.17 studies
Something wrong with this grouping? Tell us on the Eli Lilly and Company page.
Studies
Recruiting first, then most recently updated. Showing 17 of 17. All Eli Lilly and Company studies →
- A Study Evaluating the Efficacy and Safety of Pirtobrutinib in Participants With Relapsed or Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic LymphomaRecruitingNCT06588478Phase 2
Sponsor listed in the registry: Loxo Oncology, Inc. · First submitted after Loxo Oncology, Inc. became part of Eli Lilly and Company
- A Study of Pirtobrutinib (LOXO-305) Versus Ibrutinib in Participants With Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL)RecruitingNCT05254743Phase 3
Sponsor listed in the registry: Loxo Oncology, Inc. · First submitted after Loxo Oncology, Inc. became part of Eli Lilly and Company
- A Study of Pirtobrutinib (LOXO-305) Versus Bendamustine Plus Rituximab (BR) in Untreated Patients With Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL)Active, not recruitingNCT05023980Phase 3
Sponsor listed in the registry: Loxo Oncology, Inc. · First submitted after Loxo Oncology, Inc. became part of Eli Lilly and Company
- Study of BTK Inhibitor LOXO-305 Versus Approved BTK Inhibitor Drugs in Patients With Mantle Cell Lymphoma (MCL)Active, not recruitingNCT04662255Phase 3
Sponsor listed in the registry: Loxo Oncology, Inc. · First submitted after Loxo Oncology, Inc. became part of Eli Lilly and Company
- Study of LOXO-305 (Pirtobrutinib) Versus Investigator's Choice (Idelalisib Plus Rituximab or Bendamustine Plus Rituximab) in Patients With Previously Treated Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL)Active, not recruitingNCT04666038Phase 3
Sponsor listed in the registry: Loxo Oncology, Inc. · First submitted after Loxo Oncology, Inc. became part of Eli Lilly and Company
- A Study of Selpercatinib (LY3527723) in Participants With RET-Mutant Medullary Thyroid CancerActive, not recruitingNCT04211337Phase 3
Sponsor listed in the registry: Loxo Oncology, Inc. · First submitted after Loxo Oncology, Inc. became part of Eli Lilly and Company
- A Trial of Pirtobrutinib (LOXO-305) Plus Venetoclax and Rituximab (PVR) Versus Venetoclax and Rituximab (VR) in Previously Treated Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL)Active, not recruitingNCT04965493Phase 3
Sponsor listed in the registry: Loxo Oncology, Inc. · First submitted after Loxo Oncology, Inc. became part of Eli Lilly and Company
- A Study of Oral LOXO-305 in Patients With Previously Treated CLL/SLL or NHLCompletedNCT03740529Phase 1/2
Sponsor listed in the registry: Loxo Oncology, Inc. · First submitted before Loxo Oncology, Inc. became part of Eli Lilly and Company
- A Study of the Effect of Food on Selpercatinib (LY3527723) in Healthy ParticipantsCompletedNCT05324124Phase 1
Sponsor listed in the registry: Loxo Oncology, Inc. · First submitted after Loxo Oncology, Inc. became part of Eli Lilly and Company
- A Relative Bioavailability Study of Selpercatinib (LY3527723) in Healthy ParticipantsCompletedNCT05136404Phase 1
Sponsor listed in the registry: Loxo Oncology, Inc. · First submitted after Loxo Oncology, Inc. became part of Eli Lilly and Company
- A Study Comparing Two Formulations of Selpercatinib (LY3527723) in Healthy ParticipantsCompletedNCT05089019Phase 1
Sponsor listed in the registry: Loxo Oncology, Inc. · First submitted after Loxo Oncology, Inc. became part of Eli Lilly and Company
- Study of the Effect of Food and a Proton Pump Inhibitor (PPI; Omeprazole) on LOXO-305 in Healthy ParticipantsCompletedNCT05134350Phase 1
Sponsor listed in the registry: Loxo Oncology, Inc. · First submitted after Loxo Oncology, Inc. became part of Eli Lilly and Company
- Study of the Effects of Itraconazole and Rifampin on LOXO-305 in Healthy ParticipantsCompletedNCT05134337Phase 1
Sponsor listed in the registry: Loxo Oncology, Inc. · First submitted after Loxo Oncology, Inc. became part of Eli Lilly and Company
- Expanded Access Program for Pirtobrutinib for Participants With B-Cell CancerApproved for marketingNCT05172700
Sponsor listed in the registry: Loxo Oncology, Inc. · First submitted after Loxo Oncology, Inc. became part of Eli Lilly and Company
- A Drug Drug Interaction (DDI) Study of Pirtobrutinib (LY3527727) and Rosuvastatin in Healthy ParticipantsCompletedNCT05176314Phase 1
Sponsor listed in the registry: Loxo Oncology, Inc. · First submitted after Loxo Oncology, Inc. became part of Eli Lilly and Company
- A Drug Drug Interaction (DDI) Study of Selpercatinib and Dabigatran in Healthy ParticipantsCompletedNCT04782076Phase 1
Sponsor listed in the registry: Loxo Oncology, Inc. · First submitted after Loxo Oncology, Inc. became part of Eli Lilly and Company
- A Study of Pirtobrutinib (LY3527727 [LOXO-305]) Versus Placebo in Participants With Relapsing Multiple SclerosisWithdrawnNCT06104683Phase 2
Sponsor listed in the registry: Loxo Oncology, Inc. · First submitted after Loxo Oncology, Inc. became part of Eli Lilly and Company