Eisai Co., Ltd.: Epilepsy trials

The registry lists 39 Epilepsy studies with Eisai Co., Ltd. as lead sponsor. 1 are open to participants now and 17 have results posted.

Phase 1 2Phase 2 8Phase 3 9Phase 4 9No phase 11(a study in two phases counts in both)

Studies

Open to participants first, then studies with results posted, then the rest; newest registration first within each.

• An Extended Access Program (EAP) for Participants Who Have Completed Rufinamide Study E2080-G000-303AvailableNCT03778424
• A Study of Lorcaserin as Adjunctive Treatment in Participants With Dravet SyndromeTerminatedNCT04572243Phase 3Results posted
• A Study of Intravenous Perampanel in Japanese Participants With EpilepsyCompletedNCT03754582Phase 2Results posted
• A Study to Evaluate the Pharmacodynamic Activity of E2082 in Adult Participants With Photosensitive EpilepsyTerminatedNCT03686033Phase 2Results posted
• A Study to Evaluate the Pharmacodynamic Activity of E2730 in Adult Participants With Photosensitive EpilepsyTerminatedNCT03603639Phase 2Results posted
• Pharmacokinetic Study With an Oral Suspension of Perampanel as Adjunctive Therapy in Pediatric Subjects With EpilepsyCompletedNCT02914314Phase 2Results posted
• Trial Evaluating the Efficacy and Safety of Perampanel Added to Monotherapy in Participants With Partial Onset Seizures With or Without Secondary GeneralizationCompletedNCT02726074Phase 4Results posted
• An Open-label Extension Study to Evaluate the Safety and Tolerability of Perampanel (E2007) Administered as an Adjunctive Therapy in Epilepsy SubjectsCompletedNCT02427607Phase 3Results posted
• A Efficacy and Safety Study of Adjunctive Perampanel in Primary Generalized Tonic Clonic SeizuresCompletedNCT01393743Phase 3Results posted
• A Study With an Open-label Extension Phase to Evaluate the Effect of Perampanel (E2007) on Cognition, Growth, Safety, Tolerability, and Pharmacokinetics in AdolescentsCompletedNCT01161524Phase 2Results posted
• Open-label, Multi-center Trial of Zonisamide as Adjunctive Therapy in Patients With Uncontrolled Partial EpilepsyCompletedNCT01140867Phase 4Results posted
• Comparative Study of Zonisamide and Carbamazepine as an Initial Monotherapy: Efficacy and Safety EvaluationCompletedNCT01127256Phase 4Results posted
• Low and High Dose Zonisamide in Children as MonotherapyCompletedNCT01127165Phase 4Results posted
• Assessing The Long-Term Safety And To Explore The Long-Term Efficacy Of Zonisamide As Monotherapy In Newly Diagnosed Partial SeizuresCompletedNCT00848549Phase 3Results posted
• Efficacy and Safety of Adjunctive Zonisamide in Myoclonic Seizures Associated With Idiopathic Generalised EpilepsyTerminatedNCT00693017Phase 3Results posted
• Efficacy and Safety of Adjunctive Zonisamide in Paediatric Partial Onset Seizures (CATZ Study)CompletedNCT00566254Phase 3Results posted
• A Double-blind Study to Compare the Efficacy and Safety of Zonisamide and Carbamazepine as Monotherapy, in Newly Diagnosed Partial EpilepsyCompletedNCT00477295Phase 3Results posted
• A Study for Evaluating the Efficacy and Safety of Zonisamide and Lamotrigine (Lamictal) for Subjects With Refractory Simple Partial, Complex Partial or Partial With Secondary Generalized SeizuresCompletedNCT00292461Phase 3Results posted
• A Study to Evaluate the Efficacy and Safety of Perampanel Monotherapy in Untreated Participants With Focal Onset Seizures With or Without Focal to Bilateral Tonic-clonic SeizuresCompletedNCT05533814Phase 4
• A Study to Investigate Dosage, Effectiveness, and Safety of Perampanel When Used as First Add-on Therapy in Participants >=12 Years With Partial Onset Seizures With or Without Secondary Generalization or With Primary Generalized Tonic-Clonic Seizures Associated With Idiopathic Generalized EpilepsyCompletedNCT04252846
• A Study to Evaluate the Safety and Efficacy of Fycompa® (Perampanel) as Add-on Therapy in Participants With EpilepsyCompletedNCT04230044
• A Study to Evaluate Efficacy and Safety of Perampanel Administered as an Adjunctive Therapy in Pediatric Participants With Childhood EpilepsyActive, not recruitingNCT04015141Phase 2
• A Study to Assess Safety and Efficacy of Perampanel in Indian Participants as an Adjunctive Treatment in Partial Onset Seizures With or Without Secondary Generalized Seizures in Participants With Epilepsy Aged 12 Years or OlderCompletedNCT03836924
• Safety and Pharmacokinetics Study of E2007 to Treat Partial and Generalised Seizures in People With EpilepsyCompletedNCT03780907Phase 2
• Study to Investigate Dosage, Efficacy, and Safety of Fycompa in Routine Clinical Care of Patients With EpilepsyCompletedNCT03208660
• ZEDEBAC: Zebinix Effects in Dependency of Baseline ConditionsCompletedNCT03082222
• Investigation of the Clinical Safety and Efficacy of Long-term Treatment With Fycompa Tablets in Adolescence Epilepsy Patients With Partial-onset Seizures (With or Without Secondary Generalized Seizures) or Primary Generalized Tonic-clonic SeizuresCompletedNCT03059381
• Investigation of the Clinical Safety and Efficacy of Long-term Treatment With Fycompa Tablets in Adult Epilepsy Patients With Partial-onset Seizures (With or Without Secondary Generalized Seizures) or Primary Generalized Tonic-clonic SeizuresCompletedNCT03059329
• Study to Investigate Dosage, Efficacy, and Safety of Perampanel Given as Monotherapy in Patients With EpilepsyCompletedNCT02736162
• A Study of Fycompa (Perampanel) in Korean ParticipantsCompletedNCT02722590
• To Evaluate the Effect of Perampanel on Objective and Subjective Sleep in Subjects With Insomnia and Partial Onset SeizuresWithdrawnNCT02220972Phase 4
• A Global, Postmarketing Observational Safety Study to Evaluate the Safety and Tolerability of Fycompa (Perampanel) as Add-on Therapy in Epilepsy Patients Aged Greater Than or Equal to 12 YearsCompletedNCT02033902
• A Study to Demonstrate Bioequivalence Between 6 x 2 mg Tablets of Perampanel and a Single 12 mg Tablet of Perampanel in Healthy SubjectsCompletedNCT01240187Phase 1
• A Study to Investigate the Potential Pharmacokinetic Interaction of Perampanel With Oral Contraceptives in Healthy Female SubjectsCompletedNCT01209858Phase 1
• Comparing The Effect On Cognition Of Adjunctive Therapy With Zonisamide Versus Sodium ValproateCompletedNCT00713622Phase 4
• Efficacy and Safety of an add-on Treatment With Zonisamide in Adults With Focal Epileptic Seizures With or Without Secondary GeneralizationTerminatedNCT00165828Phase 4
• A Multicenter Comparative Trial of Zonisamide and Topiramate as Initial Monotherapy in Untreated EpilepsiesCompletedNCT00154076Phase 4
• E2007 Given as Adjunctive Therapy in Patients With Refractory Partial SeizuresCompletedNCT00144690Phase 2
• Dose Response Study of Zonegran in Patients With Newly Diagnosed EpilepsyCompletedNCT00056576Phase 3