Centre for Addiction and Mental Health: Schizophrenia trials

The registry lists 53 Schizophrenia studies with Centre for Addiction and Mental Health as lead sponsor. 4 are open to participants now and 3 have results posted.

Early Phase 1 1Phase 1 1Phase 2 4Phase 4 5No phase 42(a study in two phases counts in both)

Studies

Open to participants first, then studies with results posted, then the rest; newest registration first within each.

• Magnetic Seizure Therapy for Schizophrenia - TrialRecruitingNCT06672588Not applicable
• Effects of NAC on Symptoms of CHR PatientsRecruitingNCT05142735Not applicable
• "Extended" (Alternate Day) Antipsychotic DosingRecruitingNCT04478838Phase 4
• Switching From Twice-Daily to Once-Daily Clozapine Dosing in SchizophreniaRecruitingNCT02639702Phase 4
• Examining a Digital Health Approach for Advancing Schizophrenia Illness Self-management and Provider EngagementCompletedNCT04602741Not applicableResults posted
• A Study of Cognitive Adaptation Training in Inpatient Forensic EnvironmentsCompletedNCT04294719Results posted
• Feasibility and Outcomes of a Digital Health Support for the Schizophrenia SpectrumCompletedNCT03649815Early Phase 1Results posted
• Investigating the Muscarinic System in Schizophrenia Using Positron Emission TomographyActive, not recruitingNCT06278246
• The Effects of Non-invasive Neuromodulation on Illness Awareness in SchizophreniaTerminatedNCT05957484Not applicable
• Does Abnormal Insulin Action in the Brain Underlie Cognitive and Metabolic Dysfunction in SchizophreniaActive, not recruitingNCT05748990Not applicable
• Risk of Breakthrough Symptoms With Long-Acting Injectable MedicationsCompletedNCT05473741
• Does tDCS Change Synaptic Density in the Brains of Patients With SchizophreniaActive, not recruitingNCT05435300
• Community Reinforcement Approach and Family Training for Substance Use in Early Psychosis InterventionCompletedNCT05300633Not applicable
• Neuromodulation of Social Cognitive Circuitry in People With Schizophrenia Spectrum DisordersCompletedNCT04418011Not applicable
• ED to EPI: Using SMS to Improve the Transition From the Emergency Department to Early Psychosis InterventionCompletedNCT04298450Not applicable
• Early Psychosis Intervention - Spreading Evidence-based TreatmentCompletedNCT03919760Not applicable
• Cognitive Remediation Therapy for Participants With Late-Life SchizophreniaCompletedNCT03695614Not applicable
• Combining rTMS With Varenicline to Prevent Smoking Lapse in SchizophreniaWithdrawnNCT03497299Phase 2
• Gut Microbiome in AP NaiveActive, not recruitingNCT03414151
• Effects of Repetitive Transcranial Magnetic Stimulation (rTMS) on Cannabis Use and Cognitive Outcomes in SchizophreniaCompletedNCT03189810Not applicable
• Reactivity of the Vestibular System to Caloric Vestibular Stimulation in SchizophreniaCompletedNCT03048370Not applicable
• RCT Examining the Effectiveness of Digital Picture Frame Use in Inpatient SettingCompletedNCT02950571Not applicable
• The Effects of tDCS on Illness Awareness in SchizophreniaCompletedNCT02848885Not applicable
• Topiramate and Schizophrenia: Effects on Weight and PsychopathologyActive, not recruitingNCT02808533Not applicable
• Response to Clozapine in Treatment Resistant Schizophrenia: A Longitudinal Magnetic Resonance Spectroscopy StudyStatus unknownNCT02714894
• Virtual Rehabilitation for the Treatment of Motivational Deficits in SchizophreniaCompletedNCT02709733Not applicable
• Switching Antipsychotics: Abrupt Discontinuation Versus OverlapCompletedNCT02640300Phase 4
• Evaluating the Efficacy of a Late-Life Schizophrenia Integrated Care Pathway to Treat Acute Psychotic SymptomsStatus unknownNCT02529163Not applicable
• Metformin in Co-morbid Diabetes or Prediabetes and Serious Mental IllnessCompletedNCT02167620Phase 4
• Effects of Varenicline on Plasticity in SchizophreniaCompletedNCT01934023Phase 2
• rTMS for Working Memory Deficits in SchizophreniaCompletedNCT01880255Not applicable
• Effects of Varenicline on Smoking Lapse in Smokers With and Without SchizophreniaCompletedNCT01850953Phase 4
• Lifestyle Intervention for Diabetes and Weight Management in PsychosisCompletedNCT01828931Not applicable
• Deep Brain Stimulation (DBS) for the Management of Treatment Refractory Negative Symptoms in SchizophreniaWithdrawnNCT01725334Phase 1
• Antipsychotic Augmentation With L-DopaCompletedNCT01636037Phase 2
• Magnetic Seizure Therapy (MST) for Treatment Resistant Depression, Schizophrenia, and Obsessive Compulsive DisorderCompletedNCT01596608Not applicable
• Paired Associative Stimulation in the Dorsolateral Prefrontal Cortex in Patients With SchizophreniaActive, not recruitingNCT01545999Not applicable
• Effects of rTMS on Cigarette Smoking and Cognition in SchizophreniaCompletedNCT01523730Not applicable
• The Effect of Repetitive Transcranial Magnetic Stimulation (rTMS) on Working MemoryCompletedNCT01494623Not applicable
• Effects of Acute Nicotine Treatment on Neuroplasticity and Memory in Patients With SchizophreniaTerminatedNCT01465074Not applicable
• Repetitive Transcranial Magnetic Stimulation for Refractory Auditory Hallucinations in SchizophreniaCompletedNCT01386918Not applicable
• Effect of Varenicline on Cognitive Function in Cigarette Smokers With SchizophreniaCompletedNCT01093365Phase 2
• Prevention of Weight Gain in Early PsychosesCompletedNCT01075295Not applicable
• Cognitive Behavioral Social Skills Training for Patients With Late-Life Schizophrenia: a Pilot StudyCompletedNCT00832845Not applicable
• Dopamine D2 and D3 Receptor Occupancy and Clinical Response in Older Patients With SchizophreniaStatus unknownNCT00825045Not applicable
• 24-Hour Time Course of Striatal Dopamine D2 Receptor Occupancy of Ziprasidone: A PET StudyCompletedNCT00818298Not applicable
• rTMS Effects on Smoking Cessation and Cognition in SchizophreniaCompletedNCT00736710Not applicable
• Minimizing Doses of Antipsychotic Medication in Older Patients With Schizophrenia.CompletedNCT00716755Not applicable
• Anticholinergic Burden in SchizophreniaTerminatedNCT00715377Not applicable
• Antipsychotic Polypharmacy in SchizophreniaCompletedNCT00493233Not applicable
• Antipsychotic Medication Extended Dosing StudyCompletedNCT00431574Not applicable
• Neural Inhibition as a Mechanism of Nicotine Dependence Among Persons With SchizophreniaCompletedNCT00407277Not applicable
• Tetrabenazine for Partial RespondersCompletedNCT00362804Not applicable