Brigham and Women's Hospital: Sleep Apnea Syndromes trials

The registry lists 40 Sleep Apnea Syndromes studies with Brigham and Women's Hospital as lead sponsor. 6 are open to participants now and 16 have results posted.

Early Phase 1 2Phase 1 10Phase 2 17Phase 3 1No phase 20(a study in two phases counts in both)

Studies

Open to participants first, then studies with results posted, then the rest; newest registration first within each.

• Combination Tonsillectomy and Hypoglossal Nerve Stimulation for OSA Patients With Lateral Pharyngeal CollapseRecruitingNCT07724938Not applicable
• Combination Upper-Airway Electrical and Pharmacological Stimulation for Obstructive Sleep ApneaRecruitingNCT07577661Phase 1/2
• Adult Sleep Health in the Rural Appalachia and Mississippi Delta Region and Its Relationships With Cardiometabolic Health Disparities.Enrolling by invitationNCT06336525
• Trazodone on OSA EndotypesRecruitingNCT06286189Phase 1/2
• Identifying Sleep Apnea Patients That Best Respond to Atomoxetine Plus Oxybutynin TherapyRecruitingNCT05550246Phase 1/2
• Pharmacological Activation of HMN for OSA Aim 2RecruitingNCT03858751Phase 1/2
• A Novel Pharmacological Therapy for Obstructive Sleep ApneaCompletedNCT03919955Phase 2Results posted
• The Impact of Low Flow Nocturnal Oxygen Therapy on Hospital Admissions and Mortality in Patients With Heart Failure and Central Sleep ApneaTerminatedNCT03745898Phase 3Results posted
• Pharmacological Activation of HMN for OSACompletedNCT03640052Phase 1/2Results posted
• DAW1033B2 in Obstructive Sleep ApneaCompletedNCT03426631Phase 1/2Results posted
• DAW1033D in Obstructive Sleep ApneaCompletedNCT03383887Phase 1/2Results posted
• Atomoxetine and Oxybutynin in Obstructive Sleep ApneaCompletedNCT02908529Phase 1/2Results posted
• Pediatric Adenotonsillectomy Trial for SnoringCompletedNCT02562040Not applicableResults posted
• Effect of Desipramine on Upper Airway Collapsibility and Genioglossus Muscle Activity in Patients With Obstructive Sleep Apnea - Study BCompletedNCT02436031Phase 2Results posted
• Tiagabine to Enhance Slow Wave Sleep in Patients With Sleep ApneaCompletedNCT02387710Phase 2Results posted
• The Effects of Trazodone on Sleep Apnea SeverityCompletedNCT01817907Not applicableResults posted
• Memory Consolidation in Obstructive Sleep ApneaCompletedNCT01800786Not applicableResults posted
• Combination Therapy to Treat Sleep ApneaCompletedNCT01633827Not applicableResults posted
• Effects of Treatment of Sleep Apnea on Metabolic SyndromeCompletedNCT01385995Phase 2Results posted
• Sleep Apnea Intervention for Cardiovascular Disease ReductionCompletedNCT01261390Not applicableResults posted
• Positive Airway Pressure for the Treatment of AsthmaCompletedNCT01154699Not applicableResults posted
• The Effect of Eszopiclone on the Arousal Threshold in Sleep Apnea SyndromeCompletedNCT01102270Early Phase 1Results posted
• The Effect of Mouth Closure on Airflow in OSACompletedNCT06547658Not applicable
• Prevalence of Sleep Apnea and Atrial FibrillationStatus unknownNCT05155813
• Pharmacological Intervention for Symptomatic Mild Sleep Disordered BreathingCompletedNCT04611750Phase 2
• Phenotyping Mechanistic Pathways for Adverse Health Outcomes in Sleep ApneaCompletedNCT04575740Not applicable
• Healthy Sleep for Children With Down SyndromeCompletedNCT03922165
• Combination Pharmacological Interventions for Multiple Mechanisms of Obstructive Sleep ApneaCompletedNCT03892772Phase 1/2
• Effect of Dupilumab on Sleep Apnea in Patients With RhinosinusitisTerminatedNCT03675022Early Phase 1
• Combined Upper-airway and Breathing Control Therapies for Obstructive Sleep ApneaCompletedNCT03189173Phase 2
• Characterizing Upper Airway Collapse to Guide Patient Selection for Oral Appliance Therapy for Obstructive Sleep ApneaCompletedNCT02489591Not applicable
• Mechanisms of Pharyngeal Collapse in Sleep Apnea, Study CWithdrawnNCT01738022Not applicable
• Mechanisms of Pharyngeal Collapse in Sleep Apnea, Study BCompletedNCT01738009Not applicable
• Mechanisms of Pharyngeal Collapse in Sleep Apnea, Study DWithdrawnNCT01733784Not applicable
• Mechanisms of Pharyngeal Collapse in Sleep Apnea, Study ACompletedNCT01728974Not applicable
• Assessment of Sleep Apnea and Its Causes Before and After Weight Loss SurgeryTerminatedNCT01712269Not applicable
• Personalized Asthma Care TeamCompletedNCT01423461
• Cardiac Hemodynamics in Overlap Syndrome (COPD With Obstructive Sleep Apnea)WithdrawnNCT01261377Phase 1/2
• Heart Biomarker Evaluation in Apnea TreatmentCompletedNCT01086800Phase 2
• Familial Aggregation and Natural History of Sleep ApneaCompletedNCT00005299