Brigham and Women's Hospital: Sleep Apnea, Obstructive trials

The registry lists 41 Sleep Apnea, Obstructive studies with Brigham and Women's Hospital as lead sponsor. 11 are open to participants now and 17 have results posted.

Early Phase 1 2Phase 1 14Phase 2 22No phase 17(a study in two phases counts in both)

Studies

Open to participants first, then studies with results posted, then the rest; newest registration first within each.

• Combination Tonsillectomy and Hypoglossal Nerve Stimulation for OSA Patients With Lateral Pharyngeal CollapseRecruitingNCT07724938Not applicable
• Combination Upper-Airway Electrical and Pharmacological Stimulation for Obstructive Sleep ApneaRecruitingNCT07577661Phase 1/2
• Assessment of Circuit Rebreathing During CPAP TherapyRecruitingNCT07062770Not applicable
• Impacts of Opioids on Respiratory Drive During SleepNot yet recruitingNCT06854211Early Phase 1
• Trazodone on OSA EndotypesRecruitingNCT06286189Phase 1/2
• Down Syndrome Obstructive Sleep ApneaRecruitingNCT06043440Phase 2
• Identifying Sleep Apnea Patients That Best Respond to Atomoxetine Plus Oxybutynin TherapyRecruitingNCT05550246Phase 1/2
• Atomoxetine and DAW2022 on OSA SeverityRecruitingNCT05350215Phase 1/2
• Rescue Pharmacotherapy for OSARecruitingNCT05293600Phase 1/2
• DAW2020 on OSA Endotypic TraitsEnrolling by invitationNCT04538755Phase 1/2
• Pharmacological Activation of HMN for OSA Aim 2RecruitingNCT03858751Phase 1/2
• Design and Usability Testing of a Tailored Intervention About Sleep and Sleep Disorders Among Transportation WorkersCompletedNCT05039528Not applicableResults posted
• Pharmacological Activation of HMN for OSACompletedNCT03640052Phase 1/2Results posted
• DAW1033B2 in Obstructive Sleep ApneaCompletedNCT03426631Phase 1/2Results posted
• DAW1033D in Obstructive Sleep ApneaCompletedNCT03383887Phase 1/2Results posted
• Atomoxetine and Oxybutynin in Obstructive Sleep ApneaCompletedNCT02908529Phase 1/2Results posted
• Effect of Dalfampridine (4-AP) on Genioglossus Muscle Activity in Healthy AdultsCompletedNCT02656160Phase 2Results posted
• Group-based Peer Support Versus Individual Education for Patients Undergoing CPAP TreatmentCompletedNCT02538419Not applicableResults posted
• Effect of Desipramine on Upper Airway Collapsibility and Genioglossus Muscle Activity in Patients With Obstructive Sleep Apnea - Study BCompletedNCT02436031Phase 2Results posted
• Effect of Desipramine on Genioglossus Muscle Activity in Healthy Adults Study ACompletedNCT02428478Phase 2Results posted
• Tiagabine to Enhance Slow Wave Sleep in Patients With Sleep ApneaCompletedNCT02387710Phase 2Results posted
• Fire Fighter Fatigue Management Program: Operation Healthy SleepCompletedNCT01988129Not applicableResults posted
• The Effects of Trazodone on Sleep Apnea SeverityCompletedNCT01817907Not applicableResults posted
• Memory Consolidation in Obstructive Sleep ApneaCompletedNCT01800786Not applicableResults posted
• Combination Therapy to Treat Sleep ApneaCompletedNCT01633827Not applicableResults posted
• Effects of Treatment of Sleep Apnea on Metabolic SyndromeCompletedNCT01385995Phase 2Results posted
• Sleep Apnea Intervention for Cardiovascular Disease ReductionCompletedNCT01261390Not applicableResults posted
• The Effect of Eszopiclone on the Arousal Threshold in Sleep Apnea SyndromeCompletedNCT01102270Early Phase 1Results posted
• The Effect of Mouth Closure on Airflow in OSACompletedNCT06547658Not applicable
• Acetazolamide on REM OSACompletedNCT05589792Phase 1/2
• Combination Pharmacological Interventions for Multiple Mechanisms of Obstructive Sleep ApneaCompletedNCT03892772Phase 1/2
• Combined Upper-airway and Breathing Control Therapies for Obstructive Sleep ApneaCompletedNCT03189173Phase 2
• Nasal Expiratory Resistance in Patients With Sleep Apnea and Expiratory Flow LimitationWithdrawnNCT02612038Not applicable
• Characterizing Upper Airway Collapse to Guide Patient Selection for Oral Appliance Therapy for Obstructive Sleep ApneaCompletedNCT02489591Not applicable
• Mechanisms of Pharyngeal Collapse in Sleep Apnea, Study ACompletedNCT01728974Not applicable
• Assessment of Sleep Apnea and Its Causes Before and After Weight Loss SurgeryTerminatedNCT01712269Not applicable
• Fire Fighter Fatigue Management Program: Operation Fight FatigueCompletedNCT01672502Not applicable
• Cardiac Hemodynamics in Overlap Syndrome (COPD With Obstructive Sleep Apnea)WithdrawnNCT01261377Phase 1/2
• Heart Biomarker Evaluation in Apnea TreatmentCompletedNCT01086800Phase 2
• Comprehensive Police Fatigue Management ProgramCompletedNCT00246051Not applicable
• Sleep Disorders Management, Health and Safety in PoliceCompletedNCT00207285Not applicable