AstraZeneca: Renal Insufficiency, Chronic trials

The registry lists 54 Renal Insufficiency, Chronic studies with AstraZeneca as lead sponsor. 6 are open to participants now and 18 have results posted.

Phase 1 16Phase 2 9Phase 3 10Phase 4 3No phase 16(a study in two phases counts in both)

Studies

Open to participants first, then studies with results posted, then the rest; newest registration first within each.

• A Study to Investigate Outcomes With Elecoglipron Compared With Placebo in Adult Participants With Chronic Kidney Disease.RecruitingNCT07753993Phase 3
• A Phase III Study to Evaluate the Effect of Balcinrenone/Dapagliflozin in Patients With CKD Stage 3b and 4 (BalanceD-CKD)RecruitingNCT07624305Phase 3
• A Prospecitve Multicenter, Observational Registry StudyRecruitingNCT07481526
• A Study to Investigate Safety, Tolerability, PK, and PD of AZD4248 in Healthy Participants, Participants With CKD and Type 2 Diabetes, Assess Home Measurements of Creatinine in a Non-Interventional Cohort, and Assess the Effect of AZD4248 on the PK of Midazolam and Metformin in Healthy ParticipantsRecruitingNCT07024823Phase 1
• A Phase III Renal Outcomes and Cardiovascular Mortality Study to Investigate the Efficacy and Safety of Baxdrostat in Combination With Dapagliflozin in Participants With Chronic Kidney Disease and High Blood PressureRecruitingNCT06742723Phase 3
• iCaReMe Global Registry: Multinational Real-world Evidence in Cardiorenal and Metabolic DiseasesRecruitingNCT03549754
• Efficacy, Safety and Tolerability of Balcinrenone/Dapagliflozin Compared to Dapagliflozin in Adults With Chronic Kidney DiseaseCompletedNCT06350123Phase 2Results posted
• ARTEMIS: Ravulizumab to Protect Patients With CKD From CSA-AKI and MAKETerminatedNCT05746559Phase 3Results posted
• A Study to Evaluate CIN-107 for the Treatment of Patients With Uncontrolled Hypertension and Chronic Kidney DiseaseCompletedNCT05432167Phase 2Results posted
• Continuing Sodium Zirconium Cyclosilicate (SZC) After Discharge StudyCompletedNCT05347693Phase 4Results posted
• A Study to Evaluate the Effect of Sodium Zirconium Cyclosilicate on Chronic Kidney Disease (CKD) Progression in Participants With CKD and Hyperkalaemia or at Risk of HyperkalaemiaTerminatedNCT05056727Phase 3Results posted
• Study of the Effect of SZC on Serum Potassium and Serum Bicarbonate in Patients With Hyperkalemia and Metabolic Acidosis Associated With Chronic Kidney DiseaseTerminatedNCT04727528Phase 3Results posted
• Zibotentan and Dapagliflozin for the Treatment of CKD (ZENITH-CKD Trial)CompletedNCT04724837Phase 2Results posted
• A Study to Investigate the Effect of Roxadustat Versus Recombinant Human Erythropoietin (rHuEPO) on Oral Iron Absorption in Chinese Patients With Anemia of Chronic Kidney Disease (CKD)CompletedNCT04655027Phase 4Results posted
• Efficacy, Safety and Tolerability of AZD9977 and Dapagliflozin in Participants With Heart Failure and Chronic Kidney DiseaseCompletedNCT04595370Phase 2Results posted
• A Study in Healthy Subjects to Assess Drug Availability of 4 Different Formulations of Verinurad and AllopurinolCompletedNCT04550234Phase 1Results posted
• Pharmacokinetics of Verinurad and Allopurinol in Combination With Cyclosporine and Rifampicin in Healthy VolunteersCompletedNCT04532918Phase 1Results posted
• A Study of Cotadutide in Participants Who Have Chronic Kidney Disease With Type 2 Diabetes MellitusCompletedNCT04515849Phase 2Results posted
• A Study to Evaluate the Safety and Efficacy of AZD5718 in Participants With Proteinuric Chronic Kidney DiseaseTerminatedNCT04492722Phase 2Results posted
• A Study to Assess the Relative Bioavailability of 3 Different Formulations Under Fasted and Fed ConditionCompletedNCT04024501Phase 1Results posted
• A Study of Verinurad and Allopurinol in Patients With Chronic Kidney Disease and HyperuricaemiaCompletedNCT03990363Phase 2Results posted
• A Study to Evaluate the Effect of Dapagliflozin on Renal Outcomes and Cardiovascular Mortality in Patients With Chronic Kidney DiseaseCompletedNCT03036150Phase 3Results posted
• Safety & Efficacy of Zirconium Silicate in Chronic Kidney Disease or Moderate Kidney Dysfunction With Mild HyperkalemiaCompletedNCT01493024Phase 2Results posted
• AURORA: Crestor 10mg Versus Placebo in Subjects With End-stage Renal Disease (ESRD)CompletedNCT00240331Phase 3Results posted
• OPTIMISE-CKD Study_Dapagliflozin Effectiveness in CKDCompletedNCT07450820
• A Study to Investigate the Concentrations of Zibotentan and Dapagliflozin in Blood When Given With and Without FoodCompletedNCT07404137Phase 1
• A Phase IIb Study to Evaluate the Effect of Dapagliflozin in Combination With Baxdrostat Compared With Baxdrostat on Albuminuria in Participants With Chronic Kidney Disease and High Blood Pressure.Active, not recruitingNCT07222917Phase 2
• Bringing Knowledge About Chronic Kidney Disease in Brazil: Filling the GapCompletedNCT07103629
• A Study to Investigate the Safety, Tolerability and Pharmacodynamics of AZD4144 in Participants With ObesityCompletedNCT06942923Phase 1
• A Study to Investigate the Blood Concentrations of 4 Different Oral Doses of Zibotentan in Healthy Non-Asian and Japanese ParticipantsCompletedNCT06715670Phase 1
• A Study to Investigate the Pharmacokinetics, Safety, and Tolerability of AZD4144 in Participants With Severe Renal Impairment, End-stage Kidney Disease, and in Healthy ParticipantsCompletedNCT06693765Phase 1
• A Phase 1b Study to Assess the Safety, Tolerability, and Pharmacodynamics of AZD4144 in Participants With Established Atherosclerotic Cardiovascular and Chronic Kidney Disease.CompletedNCT06675175Phase 1
• A Study of Dapagliflozin in Chinese Adult Patients With Chronic Kidney DiseaseActive, not recruitingNCT06610526Phase 4
• PRospectIve ObseRvatIonal mulTicenter Study of Patients With Arterial hYpertension and CKD in the Population of RussiaCompletedNCT06372431
• Study of Ravulizumab in Immunoglobulin A Nephropathy (IgAN)Active, not recruitingNCT06291376Phase 3
• A Phase III Study to Investigate the Efficacy and Safety of Baxdrostat in Combination With Dapagliflozin on CKD Progression in Participants With CKD and High Blood Pressure.Active, not recruitingNCT06268873Phase 3
• Observational Secondary Data Study Describing Treatment With Dapagliflozin Among Adult Chronic Kidney Disease PatientsCompletedNCT06203704
• Chronic Kidney Disease Registry Platform StudyActive, not recruitingNCT06117852
• Secondary Data Analysis of Patients at Risk for CKD to Inspect CKD Prevalence, Diagnosis Rates, Diagnostic Behaviour, Treatment Patterns and Patient CharacteristicsCompletedNCT05953701
• OPTIMISE-CKD Drug UtilizationCompletedNCT05932901
• To Determine the Accuracy of SCreening for Occult REnal Disease (SCORED) Questionnaire for CKD Risk Among Asian PatientsCompletedNCT05866276
• Assessing the Effect of Multiple Doses of Zibotentan on the Pharmacokinetics of Single Doses of Combined Oral Contraceptives in Healthy Female Participants of Non-childbearing Potential.CompletedNCT05505162Phase 1
• Tracking Treatment Pathways in Adult Patients With Hyperkalemia.CompletedNCT05408039
• Safety and Pharmacokinetic Study of Subcutaneous ALXN1720 in Participants With ProteinuriaCompletedNCT05314231Phase 1
• Forxiga CKD Japan Post-Marketing Surveillance (PMS)CompletedNCT05306210
• A Randomised, Open-Label Study to Evaluate the Relative and Absolute Bioavailability of Cotadutide in Healthy SubjectsCompletedNCT05294458Phase 1
• Dapagliflozin Post Marketing Surveillance in HF and CKDCompletedNCT05134701
• Study to Collect Samples for MIST Analysis of Zibotentan and Bioavailability of Zibotentan and Dapagliflozin in Heatlhy ParticipantsCompletedNCT04991571Phase 1
• REVEAL-CKD: Prevalence and Consequences of Undiagnosed Chronic Kidney DiseaseCompletedNCT04847531
• Study to Assess Relative Bioavailability and Safety of AZD5718 in Healthy VolunteersCompletedNCT04734275Phase 1
• Patient Palatability and Preference of 3 Potassium Binders in Patients With Chronic Kidney Disease and HyperkalaemiaCompletedNCT04566653
• A Study to Evaluate the Safety and Pharmacokinetics With MEDI8367 Administered in Healthy Subjects, and in Subjects With Chronic Kidney DiseaseCompletedNCT04365218Phase 1
• A Study on Patients With Chronic Kidney Disease (CKD) to Assess Treatment Experience and Patterns, Effect of the Treatment, Patient Outcomes and Patient Quality of LifeCompletedNCT04034992
• A Study to Assess the Safety and Pharmacokinetics of Verinurad and Allopurinol in Asian and Chinese SubjectsCompletedNCT03836599Phase 1