AstraZeneca: Dyslipidemias trials

The registry lists 57 Dyslipidemias studies with AstraZeneca as lead sponsor. 1 are open to participants now and 11 have results posted.

Phase 1 17Phase 2 6Phase 3 15Phase 4 1No phase 21(a study in two phases counts in both)

Studies

Open to participants first, then studies with results posted, then the rest; newest registration first within each.

• A Study to Investigate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AZD4954 in Healthy Adult Participants With or Without Elevated Lipoprotein (a) (Lp[a]) Levels, and Participants With DyslipidemiaRecruitingNCT06980428Phase 1
• A Study to Assess the Efficacy, Safety and Tolerability of Different Doses of AZD0780 in Patients With DyslipidemiaCompletedNCT06173570Phase 2Results posted
• A Study of AZD8233 in Participants With Dyslipidemia.CompletedNCT04823611Phase 1/2Results posted
• A Study of AZD8233 in Participants With DyslipidemiaCompletedNCT04641299Phase 2Results posted
• Rosuvastatin Adherence App Study in ChinaCompletedNCT02433288Not applicableResults posted
• Epanova® for Lowering Very High Triglycerides II (EVOLVE II)CompletedNCT02009865Phase 3Results posted
• [E]PANOVA Combined With a [S]TATIN in [P]ATIENTS With HYPERT[R]IGLYCER[I]DEMIA to Reduce Non-HDL CHOLES[T]EROLCompletedNCT01408303Phase 3Results posted
• Epanova® for Lowering Very High TriglyceridesCompletedNCT01242527Phase 2/3Results posted
• Safety and Efficacy Study Comparing ABT-143 to Simvastatin in Subjects With Elevated Levels of Low Density Lipoprotein Cholesterol ("Bad Cholesterol") and TriglyceridesCompletedNCT00812955Phase 3Results posted
• 30 Week Study of the Combination of ABT-335 and Rosuvastatin Compared to Rosuvastatin Monotherapy for Subjects With Dyslipidemia and Stage 3 Chronic Kidney DiseaseCompletedNCT00680017Phase 3Results posted
• Evaluation of the Efficacy and Safety of Rosuvastatin 5 mg Versus Pravastatin 40 mg and Atorvastatin 10 mg in Type IIa and IIb Hypercholesterolaemic PatientsCompletedNCT00631189Phase 4Results posted
• A Multicenter Study Comparing the Safety and Efficacy of ABT-335 and Rosuvastatin Calcium Combination Therapy to Monotherapy in Subjects With DyslipidemiaCompletedNCT00463606Phase 3Results posted
• A Phase I, Cross-over Study Comparing the Relative Bioavailability of Laroprovstat Plus Ezetimibe Fixed Combination Drug Products Versus Their Single Therapy Products in Healthy AdultsCompletedNCT07622433Phase 1
• A Study to Assess the Effect of AZD0780 on the Pharmacokinetics of AZD4954 and Vice Versa in Healthy AdultsCompletedNCT07513571Phase 1
• A Study to Investigate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics With AZD0780 Following Repeated Dose Administration in Healthy Adults With Elevated LDL-C LevelsCompletedNCT07423598Phase 1
• A Phase I Study Comparing the Relative Bioavailability of a Fixed-Dose Combination of Laroprovstat/Rosuvastatin vs Their Single Therapy Products in Healthy AdultsCompletedNCT07316608Phase 1
• A Study to Investigate the Effect of AZD0780 Tablets in Combination With Rosuvastatin Tablets on Low Density Lipoprotein Cholesterol Levels (LDL-C) in Adult Participants With DyslipidaemiaCompletedNCT07218900Phase 2
• A Study to Investigate the Effect of AZD0780 on Metformin Pharmacokinetics in Healthy Adult Volunteers Aged 18 to 55 YearsCompletedNCT07216131Phase 1
• A Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of AZD0780 in Participants With DyslipidaemiaActive, not recruitingNCT06834932Phase 2/3
• A Study to Investigate the Pharmacokinetics, Safety, Tolerability, and Efficacy of AZD0780 With Ezetimibe Combinations in Healthy Adults With Elevated LDL-C.CompletedNCT06742853Phase 1
• An Open-label Study in Healthy Participants to Evaluate AZD0780 as an Object or Precipitant of CYP3A4-mediated Drug-drug InteractionsCompletedNCT06671405Phase 1
• A Study to Investigate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AZD1705 in Participants With DyslipidemiaActive, not recruitingNCT06238466Phase 1
• An ADME Study of [14C]AZD0780 in Healthy Male SubjectsCompletedNCT05817461Phase 1
• A Study to Assess the Effect of AZD0780 on the Pharmacokinetics of Rosuvastatin.CompletedNCT05787002Phase 1
• A Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AZD0780 in Healthy SubjectsCompletedNCT05384262Phase 1
• To Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AZD8233 After Multiple Dose Administration in Subjects With DyslipidemiaCompletedNCT04155645Phase 1
• A Study to Understand the Safety, Tolerability, and Activity of Drug in Body Over a Period of Time of AZD2693, in Subjects of Non-Childbearing Potential in Overweight But Otherwise Healthy Subjects, and Healthy Chinese and Japanese SubjectsCompletedNCT04142424Phase 1
• A Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of AZD6615 in Healthy SubjectsTerminatedNCT04055168Phase 1
• CEntralized Pan-Russian Survey of tHE Undertreatment of hypercholeSterolemia II (CEPHEUS II)CompletedNCT02230241
• Evaluation of Patients Treated With HMG-CoA Reductase Inhibitors to Reach Cholesterol Target ValuesCompletedNCT01483950
• Cholesterol Goal Attainment Rate and Its Associated Factors Among Dyslipidemic Patients on Lipid-lowering Drug Therapy in KoreaCompletedNCT01372956
• Management of Dyslipidemia in Adult Type 2 Diabetes Patients in IndiaCompletedNCT01292018
• Dyslipidemia Treatment in Thailand and Cardiovascular OutcomesWithdrawnNCT01265836
• Prevalence of Subclinical Atherosclerosis and Its Associated Factors in Hyperlipidemic Korean Adults With DiabetesCompletedNCT01264263
• Centralized Pan-Russian Survey on the Undertreatment of HypercholesterolemiaCompletedNCT01221584
• Efficiency of Rosuvastatin Versus the Fixed Combination of Ezetimibe/Simvastatin in OutpatientsCompletedNCT01164397
• Study of Undertreatment of Patients With Dyslipidemia in BulgariaCompletedNCT01075594
• Statin Therapy Results in the Real World Practice in the Czech RepublicCompletedNCT01055977
• Observational Study to Estimate the Rates of Outcomes in Patients Undergoing Percutaneous Coronary Intervention (PCI) With Drug Eluting Stent (DES) Implantation Who Take StatinsCompletedNCT01047176
• Observational Study To Evaluate Statins Patterns Of Use In SpainWithdrawnNCT01023503
• Investigation Into the RAtio of LDL-CHolestEroL to HDL-Cholesterol Improvement After Statin Treatment in Korean PatientsCompletedNCT00931320
• National Survey on Dyslipidemic PatientsCompletedNCT00701402
• National Survey on Coronary Patients and Heart Failure Performed in 2 Patient GroupsCompletedNCT00699959
• Survey of Lipid Goal Attainment and Mortality in Patients With High Cardiovascular Risk in ThailandCompletedNCT00684151
• 48-wk Open Label Phase IIIb to Evaluate Efficacy and SafetyCompletedNCT00654602Phase 3
• IIIb 6 Week Open Label Multicentre Rosuvastatin & SimvastatinCompletedNCT00654446Phase 3
• Treatment of Hypercholesterolaemia in South Asian Subjects (IRIS)CompletedNCT00654225Phase 3
• Comparing the Efficacy and Safety of Rosuvastatin With Atorvastatin and Simvastatin (SOLAR)CompletedNCT00654173Phase 3
• Treatment of Hypercholesterolaemia in Hispanic Subjects (STARSHIP)CompletedNCT00653965Phase 3
• Rosuvastatin Versus Atorvastatin in the Treatment of Hypercholesterolaemia in African American Subjects(ARIES)CompletedNCT00653744Phase 3
• Safety Study to Evaluate the Effects of Mild and Moderate Renal Impairment on the Pharmacokinetics of ABT-335 and Rosuvastatin When Administered ConcomitantlyCompletedNCT00585143Phase 1
• Education and Awareness Program Targeting the Assessment of Adherence of the Treatment of DyslipidemiaCompletedNCT00557778
• Crestor RUSH (The Efficacy of RosUvaStatin for Korean Dyslipidemia Patients With Hypertension )CompletedNCT00526708
• Crestor RAPID (The Efficacy of RosuvAstatin for Korean Dyslipidemia PatIents With Diabetes)CompletedNCT00526552
• InPractice Survey on the Treatment of HypercholesterolemiaCompletedNCT00523796
• A Study to Investigate the Effect of Rosuvastatin (CRESTOR®) on High Density Lipoprotein Kinetics in Patients With the Metabolic SyndromeCompletedNCT00240305Phase 3
• Study of High Density Lipoprotein Cholesterol (HDL-C)-Raising Mechanism of Rosuvastatin (CRESTOR™) by Quantifying the Key Steps of Reverse Cholesterol Transport (RCT)CompletedNCT00240266Phase 3