Amgen: Renal Insufficiency trials

The registry lists 13 Renal Insufficiency studies with Amgen as lead sponsor. 0 are open to participants now and 6 have results posted.

Phase 1 6Phase 2 2Phase 3 1Phase 4 4(a study in two phases counts in both)

Studies

Open to participants first, then studies with results posted, then the rest; newest registration first within each.

• Study to Evaluate the Safety, Tolerability and Pharmacokinetics of AMG 986 Administered Orally to Healthy Volunteers and Participants With Severely Impaired Renal FunctionCompletedNCT03318809Phase 1Results posted
• Estimation Study to Assess the Effect of Severe Renal Impairment and End-stage Renal Disease Hemodialysis on the Pharmacokinetics of EvolocumabCompletedNCT02275156Phase 1Results posted
• Study of Romosozumab (AMG 785) Administered to Healthy Participants and Patients With Stage 4 Renal Impairment or Stage 5 Renal Impairment Requiring HemodialysisCompletedNCT01833754Phase 1Results posted
• Multiple Dose Study to Evaluate the Safety of Multiple Doses of Denosumab 120 mg in Adults With Severe Chronic Kidney Disease (CKD) and CKD on DialysisCompletedNCT01464931Phase 1Results posted
• Study of the Safety and Pharmacokinetics of Carfilzomib in Patients With Relapsed and Refractory Multiple Myeloma and Varying Degrees of Renal FunctionCompletedNCT00721734Phase 2Results posted
• Study for Secondary Hyperparathyroidism in Chronic Renal Insufficiency PatientsCompletedNCT00042432Phase 2Results posted
• A Study to Evaluate the Pharmacokinetics, Safety, and Pharmacodynamics of Olpasiran in Participants With Normal Renal Function and Participants With Various Degrees of Renal ImpairmentCompletedNCT05489614Phase 1
• A Pharmacokinetic Study of AMG 386 in Cancer Subjects With Normal and Impaired Renal FunctionCompletedNCT01331941Phase 1
• STAAR-1 Clinical StudyCompletedNCT00369772Phase 4
• STAAR-3 Clinical StudyCompletedNCT00369733Phase 4
• STAAR-2 Clinical StudyCompletedNCT00368901Phase 4
• Evaluating Aranesp® for the Treatment of Anemia in African-American Subjects With Chronic Renal Failure (CRF) Receiving HemodialysisCompletedNCT00111995Phase 4
• Study Evaluating Darbepoetin Alfa in Subjects With Chronic Kidney Disease (CKD) Receiving DialysisCompletedNCT00096915Phase 3