Amgen: Leukemia trials

The registry lists 25 Leukemia studies with Amgen as lead sponsor. 0 are open to participants now and 17 have results posted.

Early Phase 1 1Phase 1 11Phase 2 8Phase 3 2Phase 4 1No phase 4(a study in two phases counts in both)

Studies

Open to participants first, then studies with results posted, then the rest; newest registration first within each.

• Study to Investigate Intravenous Blinatumomab in Japanese Adult Participants With Newly Diagnosed Philadelphia-negative B-precursor Acute Lymphoblastic Leukemia (B-ALL)CompletedNCT06649006Phase 1Results posted
• Blinatumomab in Combination With AMG 404 for the Treatment of Adults With Relapsed or Refractory B Cell Precursor ALLCompletedNCT04524455Phase 1Results posted
• Feasibility Study to Evaluate Outpatient Blinatumomab in Subjects With Minimal Residual Disease (MRD) of B-precursor Acute Lymphoblastic Leukemia (ALL)TerminatedNCT04506086Phase 4Results posted
• Study of AMG 330 in Combination With Pembrolizumab in Adult With Relapsed or Refractory Acute Myeloid LeukemiaTerminatedNCT04478695Phase 1Results posted
• Safety, Tolerability, PK, PD, and Efficacy of AMG 427 in Subjects With Relapsed/Refractory Acute Myeloid LeukemiaTerminatedNCT03541369Phase 1Results posted
• Efficacy and Safety of the BiTE Antibody Blinatumomab in Chinese Adult Subjects With Relapsed/Refractory B-precursor Acute Lymphoblastic Leukemia (ALL)CompletedNCT03476239Phase 3Results posted
• Safety, Tolerability, Pharmacokinetics and Efficacy of AMG 397 in Subjects With Selected Relapsed or Refractory Hematological MalignanciesTerminatedNCT03465540Phase 1Results posted
• Study of Emerfetamab (AMG 673) in Adults With Relapsed/Refractory Acute Myeloid Leukemia (AML)TerminatedNCT03224819Early Phase 1Results posted
• Study of Blinatumomab in Japanese Patients With Relapsed/Refractory B-precursor Acute Lymphoblastic LeukemiaCompletedNCT02412306Phase 1/2Results posted
• Study of Carfilzomib in Combination With Induction Chemotherapy in Children With Relapsed or Refractory Acute Lymphoblastic LeukemiaCompletedNCT02303821Phase 1Results posted
• Blinatumomab Versus Standard of Care Chemotherapy in Patients With Relapsed or Refractory Acute Lymphoblastic Leukemia (ALL)TerminatedNCT02013167Phase 3Results posted
• Blinatumomab in Adults With Relapsed/Refractory Philadelphia Positive B-precursor Acute Lymphoblastic LeukemiaCompletedNCT02000427Phase 2Results posted
• Clinical Study With Blinatumomab in Pediatric and Adolescent Patients With Relapsed/Refractory B-precursor Acute Lymphoblastic LeukemiaCompletedNCT01471782Phase 1/2Results posted
• Clinical Study With Blinatumomab in Patients With Relapsed/Refractory B-precursor Acute Lymphoblastic Leukemia (ALL)CompletedNCT01466179Phase 2Results posted
• Study of the BiTE® Blinatumomab (MT103) in Adult Patients With Relapsed/Refractory B-Precursor Acute Lymphoblastic Leukemia (ALL)CompletedNCT01209286Phase 2Results posted
• Confirmatory Phase II Study of Blinatumomab (MT103) in Patients With Minimal Residual Disease of B-precursor Acute Lymphoblastic Leukemia (ALL)CompletedNCT01207388Phase 2Results posted
• Phase II Study of the BiTE® Blinatumomab (MT103) in Patients With Minimal Residual Disease of B-precursor Acute Lymphoblastic Leukemia (ALL)CompletedNCT00560794Phase 2Results posted
• Study Evaluating the Safety, Tolerability, and Efficacy of FLT3 CAR-T AMG 553 in FLT3-positive Relapsed/Refractory AMLWithdrawnNCT03904069Phase 1
• An Study of Patients With Ph- Chromosome-negative Relapsed or Refractory Acute Lymphoblastic Leukemia in the USCompletedNCT02783651
• Historical Data Analysis of Complete Remission in Children With R/R Acute Lymphoblastic Leukemia (ALL)CompletedNCT02303522
• Retrospective Analysis of Survival in Adult MRD Positive Acute Lymphoblastic Leukemia PatientsCompletedNCT02010931
• Historical Data Analysis of Hematological Remission and Survival in Adults With R/R Acute Lymphoblastic LeukemiaCompletedNCT02003612
• Study Evaluating Orally Administered AMG 900 in Adult Subjects With Acute Myeloid LeukemiaCompletedNCT01380756Phase 1
• AMG 319 Lymphoid Malignancy FIHCompletedNCT01300026Phase 1
• Trial Comparing Pegfilgrastim With Filgrastim as an Adjunct to Chemotherapy for Acute Myeloid Leukaemia (AML)CompletedNCT00114764Phase 2